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Exposure Research

Human Exposure & Atmospheric Sciences Staff

Daniel T. Chang

Title: Research Physical Scientist

EPA Division: Human Exposure and Atmospheric Sciences Division

EPA Branch: Exposure and Dose Research Branch

Narrative:
Daniel’s expertise is in the development and application of computational chemistry methods as they pertain to exposure assessments. He is interested in the application of chemoinformatics and high-level computational chemistry methods (quantitative structure-activity relationships, molecular dynamics, docking, variational transition-state theory, ab initio and semiempirical molecular orbital theory calculations) towards estimating unknown chemical-specific parameters utilized within physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models. Current projects are focused on the application, development and interpretation of models to estimate and elucidate chemical properties, their chemical domains of applicability and their use to create high-throughput prioritization schemes—including but not limited to their biotransformation, transport across physiological barriers and distribution and elimination within a biological system. Previous research includes chemical kinetics, solvation theory, development of hybrid classical/quantum mechanical methods to study condensed phase dynamics, and understanding the chemical fate of environmental contaminants.

Education/Training:

  • Ph.D., Chemical Physics, Texas Tech University, 2002
  • M.S., Chemical Physics, Texas Tech University, 1999
  • B.A., Chemistry, Rice University, 1993

Professional Experience:

  • Research Physical Scientist, USEPA, ORD, NERL-HEASD, RTP, NC 2009-present
  • Research Physical Scientist, USEPA, ORD, NERL-HEASD, Las Vegas, NV 2007-2009
  • Postdoctoral Fellow, USEPA, ORD, NERL-HEASD, Las Vegas, NV 2005-2007
  • Postdoctoral Fellow, Pacific Northwest National Laboratory, Richland, WA 2003-2005

Professional Societies and Affiliations:

  • American Chemical Society

Select Awards and Honors:

  • USEPA-ORD Bronze Medal for Commendable Service: Chemical Safety for Sustainability, 2012
  • USEPA-ORD Level III Scientific and Technological Achievement Award: Development of Visual Tools and Analytics within the Human Health Risk Assessment Paradigm, 2011
  • USEPA-ORD Pathfinder Innovation Project Funding Award Recipient: Systems Reality Modeling Project, 2011
  • USEPA-NERL Team Award: Anticipate Future Environmental Issues, 2010
  • USEPA-NERL Team Award: Pyrethroid Research Team, 2009
  • USEPA-ORD Technical Assistance Award: PBPK Modeling Team, 2007

Select Presentations:

  • D. T. Chang, M.-R. Goldsmith, R. Tornero-Velez, Y.-M. Tan, J. C. Johnson, S. D. Peterson, J. Pliel and C. C. Dary. 2010. Interpreting and understanding the excreta space of chemical biomarkers: A case study using the National Health and Nutrition Examination Survey (NHANES) dataset, Pacifichem, Honolulu, HI.
  • D. T. Chang. 2010. Rapid ADME Estimates. US EPA Exposure-Based Chemical Prioritization Workshop, Exploring Opportunities for Collaboration, Research Triangle Park, NC.
  • D. T. Chang, M.-R. Goldsmith, T. R. Transue, R. Tornero-Velez, S. D. Peterson, Y.-M. Tan and C. C. Dary, Plasma-binding Parameters in the Embryonic Compartment: An In Silico Screening Tool for alpha-Fetoprotein, 49th Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 2010
  • M.-R. Goldsmith, T. R. Transue, D. T. Chang, R. Tornero-Velez, S. D. Peterson, J. C. Johnson, M. S. Breen and C. C. Dary, Whole-body Visualization of Physiologically-Relevant Data: Of Mice and Men, 49th Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 2010
  • D. T. Chang, M.-R. Goldsmith, R. Tornero-Velez, L.-J. Chen , E. Ulrich, A. B. Lindstrom, and C. C. Dary, A Novel Application of QSAR and PH4 Models for the Elucidation of the Stereoselective Hydrolysis Rates of Pyrethroids by Rat Serum Carboxylesterase, Society of Environmental Toxicology and Chemistry, New Orleans, LA, November 2009
  • D. T. Chang, Utilizing In Silico Techniques to Elucidate the Stereoselective Behaviour of Pyrethroids within Carboxylesterase, 234th ACS National Meeting, Modern Chiral Agrochemicals: the Importance of Enantioselectivity in Fate and Effects Symposium, Boston, MA, August 2007

Select Publications:

  • D. T. Chang, M.-R. Goldsmith, R. Tornero-Velez, Y.-M. Tan, C. M. Grulke, E. M. Ulrich, A. B. Lindstrom, M. A. Pasquinelli, J. R. Rabinowitz and C. C. Dary, In Silico Strategies for Modeling Stereoselective Metabolism of Pyrethroids, Parameters for Pesticide QSAR and PBPK/PD models for Human Risk Assessment, ACS Symposium Series 1099, American Chemical Society, Washington DC, pp 245-269 (2012)
  • M.-R. Goldsmith, S. D. Peterson, D. T. Chang, T. R. Transue, R. Tornero-Velez, Y.-M. Tan and C. C. Dary, Informing Mechanistic Toxicology with Computational Molecular Models, Computational Toxicology (Methods in Molecular Biology) 929, Humana Press, Springer Science, NY, pp 139-165 (2012)
  • J. B. Knaak, C. C. Dary, X. Zhang, R. W. Gerlach, R. Tornero-Velez, D. T. Chang, M.-R. Goldsmith, J. N. Blancato, Parameters for Pyrethroid Pesticide QSAR and PBPK/PD Models for Human Risk Assessment, Rev. Environ. Contam. Tox., 219, 1 (2012)
  • Y.-M. Tan, J. Sobus, D. T. Chang, R. Tornero-Velez, M.-R. Goldsmith, J. Pleil and C. C. Dary, Reconstructing Human Exposures Using Biomarkers and other “Clues”, J. Toxicol. Env. Heal. B, 15, 22 (2012)
  • M.-R. Goldsmith, T. R. Transue, D. T. Chang, R. Tornero-Velez, M. S. Breen and C. C. Dary, PAVA: Physiological and Anatomical Visual Analytics for Mapping of Tissue-specific Concentrations and Time-Course Data, J. Pharmacokin. Pharmacodyn., 37, 277 (2010)
  • D. T. Chang, G. K. Schenter and B. C. Garrett, Self-consistent Polarization NDDO: Application to Neutral Water Clusters, J. Chem. Phys., 128, 119 (2008)

Published & Presented Research (1999-Present)

Contact Info:
Daniel T. Chang
Human Exposure & Atmospheric Sciences Division
National Exposure Research Laboratory
US EPA Office of Research and Development
109 TW Alexander Drive
Research Triangle Park, NC 27709
Telephone: 919-541-0875
Email: chang.daniel@epa.gov

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