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Exposure Research

Human Exposure & Atmospheric Sciences Staff

Michael-Rock Goldsmith

Title: Research Physical Scientist

EPA Division: Human Exposure and Atmospheric Science Division

EPA Branch: Exposure Dose Research Branch

Narrative:
Dr. Goldsmith develops computer models that quantify the process of how chemicals enter the body and where in the body they may end up. Dr. Goldsmith also creates new ways to animate and visualize this type of “pharmacokinetic” data. More recently his research focus has been in the development of new tools to estimate how much chemical exposure one may get on a daily basis from “where I am, to where I work, to what I do at home, to what products I use”; a sub-domain of exposure science he refers to as personal chemical exposure informatics.

Education/Training:

  • Ph.D., Chemistry & Graduate Certificate in Molecular Biophysics, Duke University, 2005 Thesis Title: Modeling the Chiroptical Response Properties of Chiral Non-Covalent Molecular Aggregates and Natural Products - Advisors: David N. Beratan (primary) and Peter Wipf (secondary)
  • B.Sc., Honors Chemistry, CO-OP, Concordia University, 1998 Thesis Title: 2D Phase transitions of CO/LiF and CO/NaCl (001) adsorbate systems via Monte Carlo simulations January 1998- May 1998 - Advisor: David B. Jack

Professional Experience:

  • Research Physical Scientist – Principal Investigator in the Exposure Dose Research Branch (EDRB), USEPA, ORD, NERL-HEASD, Research Triangle Park, NC 2008-present (http://www.epa.gov/heasd/edrb/staff/goldsmith.html)
  • Chemist - Post-Doctoral Fellow, National Center for Computational Toxicology,UNC-Chapel Hill, School of Public Health - Department of Environmental Science and Engineering, Chapel Hill, NC 2006-2007; UNC Post-Doctoral Trainee in Computational Toxicology, USEPA
  • Research Assistant/Chemistry Graduate Student, Duke University, Durham NC 2001-2005
  • Research Assistant/Chemistry Graduate Student, University of Pittsburgh, Pittsburgh PA 2000 - 2001
  • PR&D Analyst, Ethypharm DDS Inc., Laval, Quebec 1999-2000
  • Undergraduate Junior Research Scientist (NSERC Award), CO-OP 4, Orica* Canada, McMasterville, Quebec May 1998-August 1998
  • Undergraduate R&D, Product Engineering, Packaging Group, CO-OP 3, Imperial Tobacco Ltd., Montreal, Quebec September 1997-December 1997
  • Undergraduate PR&D Analytical Chemist (NSERC Award), CO-OP 2, Merck Frosst Canada, Kirkland, Quebec January 1997-April 1997
  • Undergraduate QA Analytical Chemist, CO-OP 1, Ciba-Geigy Pharmaceuticals, Dorval, Quebec May 1996-August 1996

Professional Societies and Affiliations:

  • American Chemical Society, 2000-present
  • Triangle Reproductive Biology Consortium, 2006-present
  • Editor, Journal of Computational Medicine (Hindawi Press)

Select Awards and Honors:

  • USEPA, Pathfinder Innovation Project (PIP1), Funding Award Recipient, 2011
  • USEPA, The 2011 Level III STAA award, Nomination ID: S11HE0045, August 2012
  • USEPA, The 2010 Level III STAA award, May 2011
  • USEPA, NERL special Achievement Award, March 2011
  • USEPA, Goal 5 – Anticipate Future Environmental Issues Research Award, March 2010
  • USEPA, NERL Teamwork Award, March 2009
  • USEPA, On-The-Spot Award for Pyrethroids Models, March 2008

Graduate Scholarships and Fellowships:

  • Duke University, Recipient of graduate level support from the NLM Duke Biophysics Graduate Research funding, 2003-2004
  • Duke University, Two-time recipient of the Duke Graduate Student Travel Grant (2004- APS, Montreal / 2003 - SETCA, Clemson), 2003, 2004
  • University of Pittsburgh, Aristech Graduate Fellowship - University of Pittsburgh, 2000
  • University of Pittsburgh, Chair’s Scholar Grant – University of Pittsburgh, 2000

Select Presentations:

  • PerCEIVERS 2012 – Primary Workshop Organizer & Opening Presenter: http://www.epa.gov/ncct/expocast/percei.html
  • GlobalChem March 2012 – (Baltimore, MD): “Exposure Assessment 2.0 – Methods & Models Research” – Michael-Rock Goldsmith (Presentation)
  • SOT 2012 – March (San Francisco, CA): Personal chemical exposure informatics: Creation of a consumer products chemical ingredient database – Rocky Goldsmith,1 Christopher Grulke,1 Thomas Transue,4 Daniel Chang1, Rogelio Tornero-Velez,1 Curtis Dary,2 Kathleen Holm,1 Cecilia Tan,1 Peter Egeghy,1 Jade-Mitchell-Blackwood,1 Linda Phillips,3 Daniel Vallero,1
  • ExpoCast - Exposure Prioritization Workshop – September 2011: Goldsmith / Meek – lead: Minimal dataset & Harnessing technology for collection of consumer use data (Goldsmith) – Presentation http://www.epa.gov/ncct/expocast/exposure_based_2_agenda.html
  • ISES 2011 – Baltimore. Course Instructor - http://www.epa.gov/nerl/download_files/documents/2011ISES/Workshop/ISES_Workshops_PharmacokineticModeling.pdf
  • SOT 2011 – March (Washington DC): Tan, Y. Goldsmith, M.-R., Chang, D.; Zhang, X.; Tornero-Velez, R.; Johnson, J.; Dary, C.C. The Value of Information from Provisional PBPK models in Support of Biomonitoring: The Case of Atrazine. . SOT, March 2011, Washington DC

Select Publications:

  • Tornero-Velez R, Davis J, Scollon EJ, Starr JM, Setzer RW, Goldsmith MR, Chang DT, Xue J, Zartarian V, DeVito MJ, Hughes MF. A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application. Toxicol. Sci. (2012) 130 (1): 33-47. doi: 10.1093/toxsci/kfs236 - http://toxsci.oxfordjournals.org/content/early/2012/07/31/toxsci.kfs236.short
  • Yu-Mei Tan, Curtis Dary, Daniel Chang, Michael Goldsmith, Rogelio Tornero-Velez, Joachim Pleil, Jon Sobus. A Detective Story: Reconstructing Human Exposures Using Biomarkers of Exposure and Other “Clues”. Journal of Toxicology and Environmental Health, Part B, Volume 15, Issue 1, 2012, Page 22-38
  • C. M. Grulke, M.-R. Goldsmith, and D. A. Vallero. Towards a blended Ontology: Applying knowledge systems to compare therapeutic and toxicological Nanoscale domains. J Biomed Biotechnol. 2012;2012:308381. doi: 10.1155/2012/308381. Epub 2012 May 6.- http://www.hindawi.com/journals/bmri/2012/308381/
  • James B. Knaak, Curtis C. Dary, Xiaofei Zhang, Robert W. Gerlach, R. Tornero-Velez, Daniel T. Chang, Rocky Goldsmith and Jerry N. Blancato. Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment. Rev Environ Contam Toxicol. 2012;219:1-114. doi: 10.1007/978-1-4614-3281-4_1. – Review - (http://www.ncbi.nlm.nih.gov/pubmed/22610175 )
  • Elin M. Ulrich , Candice N. Morrison, Michael R. Goldsmith, and William T. Foreman. Chirality in agrochemicals. Rev Environ Contam Toxicol. 2012;217:1-74. doi: 10.1007/978-1-4614-2329-4_1. Review. - http://www.ncbi.nlm.nih.gov/pubmed/22350557
  • Yu-Mei Tan, Curtis Dary, Daniel Chang, Michael Goldsmith, Rogelio Tornero-Velez, Rory Connoly. Book Chapter: “Computational Toxicology in Environmental Research.” Methods Mol Biol. 2012;929:9-19. [ Book Chapter ] - http://www.ncbi.nlm.nih.gov/pubmed/23007424

Published & Presented Research (1999-Present)

Contact Info:
Michael-Rock Goldsmith
Human Exposure & Atmospheric Sciences Division
National Exposure Research Laboratory
US EPA Office of Research and Development
109 TW Alexander Drive
Research Triangle Park, NC 27709
Telephone: 919-541-0497
Email: goldsmith.rocky@epa.gov

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