Human Exposure & Atmospheric Sciences Staff
EPA Division: Human Exposure and Atmospheric Sciences Division
EPA Branch: Exposure Dose Research Branch
The development of tools to aid in the understanding of the exposure-dose relationship is a critical linchpin in elucidating the potential dangers an environmental contaminant may present. Bridging the gap between a recipient’s contact with a pollutant and the concentrations of that pollutant reaching the biological site of action are vital to assess the potential toxicity causes by an exposure. Christopher’s focus is to develop state of the science informatics tools to enable quick assessment of a chemical’s exposure-dose characteristics with particular emphasis on metabolic degredation.
- Ph.D., Pharmaceutical Sciences, University of North Carolina, Chapel Hill, 2011
- B.S.E., Chemical Engineering, University of Michigan, Ann Arbor, 2003
- Chemical Informatics Contractor, Pfizer Global Research and Development, May 2008-August 2008
- Research Informatics Internship, Pfizer Global Research and Development, September 2003-August 2004
- Computer Aided Drug Design Internship, Pfizer Global Research and Development, May 2003-September 2003
Professional Societies and Affiliations:
- American Chemical Society
- American Association of Pharmaceutical Scientists
- Walker T, Grulke CM, Pozefsky D, Tropsha A. Chembench: a cheminformatics workbench. Bioinformatics. 2010 Dec 1;26(23):3000-1. Epub 2010 Sep 30.
- Hajjo R, Grulke CM, Golbraikh A, Setola V, Huang XP, Roth BL, Tropsha A. Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs. J Med Chem. 2010 Nov 11;53(21):7573-86.
Human Exposure & Atmospheric Sciences Division
National Exposure Research Laboratory
US EPA Office of Research and Development
109 TW Alexander Drive
Research Triangle Park, NC 27709