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Exposure Research

Human Exposure & Atmospheric Sciences Staff

Kristin King Isaacs

Title: Research Physical Scientist

EPA Division: Human Exposure and Atmospheric Sciences Division

EPA Branch: Exposure Modeling Research Branch

Narrative:
The focus of Kristin’s current research is the development and evaluation of computational and stochastic human exposure and dose models and their associated algorithms for use in human risk assessments of air pollutants and multimedia/multipathway chemicals. Her specific research interests and responsibilities include: the development of physiology-based energy expenditure prediction methods for exposure and dose models; development of inhalation and dietary dose algorithms for in-depth risk assessments and for chemical screening and prioritization; monitoring, assessment, and simulation of human activity patterns in support of exposure and risk assessment; development and evaluation of residential chemical source-to-concentration models; and development and application of sensitivity and uncertainty analyses for exposure and dose models.

Education/Training:

  • Ph.D., Biomedical Engineering, Vanderbilt University, 2002 Thesis Title: Visualization-based sensitivity and identifiability analyses for models of capillary transport and pharmacokinetics
  • M.S., Biomedical Engineering, University of Kentucky, 1999 Thesis Title: Time-frequency and coarse-graining spectral analyses of heart rate variability : prediction of orthostatic intolerance
  • B.S., Mechanical Engineering, University of Kentucky, Magna Cum Laude, 1994

Professional Experience:

  • Research Physical Scientist, USEPA, ORD, NERL, 2010-present
  • Senior Mathematician/Statistician. Alion Science and Technology, Inc. Research Triangle Park, NC 2004-2010
  • Postdoctoral Fellow, USEPA, ORD, NHEERL, and Department of Environmental Sciences and Engineering, University of North Carolina- Chapel Hill, Research Triangle Park, NC 2002-2004
  • Research Assistant/Graduate Fellow, Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 1996-2002
  • Research Assistant, University of Kentucky, Department of Biomedical Engineering, Lexington, KY 1994-1996
  • Co-Op Engineer, Body Production Engineering, Toyota Motor Manufacturing USA, Georgetown, KY 1992-1994

Professional Societies and Affiliations:

  • International Society for Exposure Science
  • National Collaborative on Childhood Obesity Research (NCCOR) Expert Panel on Youth Energy Expenditure (Team 2, Energy Expenditure Metrics), 2012-present

Select Awards and Honors:

  • USEPA, Exceptional/Outstanding ORD Technical Assistance to the Regions or Program Offices Award, 2010
  • National Institutes of Health Training Grant in Quantitative Physiology, 1996-2000
  • Vanderbilt University Graduate Fellowship, 1996-2001
  • University of Kentucky Graduate Fellowship, 1994-1996

Select Presentations:

  • "Development and Evaluation of a Fugacity-Based Source-to-Concentration Module for SHEDS-Multimedia" Isaacs, K., Glen, G., Stout, D. and Bennett, D. 22nd Annual Conference of the International Society of Exposure Analysis, Seattle, Washington, October 28 – November 1, 2012.
  • "Challenges in Building a Framework for Rapid Collection and Dissemination of Human Activity Data for Use in Exposure and Risk Assessment" Isaacs, K. and Goldsmith, M. 22nd Annual Conference of the International Society of Exposure Analysis, Seattle, Washington, October 28 – November 1, 2012.
  • "EPA’s SHEDS-Multimedia Model: Pyrethroids Exposure Estimates and Evaluation Against Measurements Data" Xue, J., Zartarian, V., Isaacs, K., Tornero-Velez, R. 22nd Annual Conference of the International Society of Exposure Analysis, Seattle, Washington, October 28 – November 1, 2012.
  • "Improving Energy Expenditure Estimates for Human Exposure Models." Isaacs, K., McCurdy, T., and McMurray, R. 21st Annual Conference of the International Society of Exposure Analysis, Baltimore, Maryland, October 23 – 27, 2011.
  • "Filling gaps in human activity data for characterizing longitudinal patterns and tracking shifts in children’s behaviors." Isaacs, K. and McCurdy, T. 21st Annual Conference of the International Society of Exposure Analysis, Baltimore, Maryland, October 23 – 27, 2011.
  • "Estimating Residential and Dietary Exposures to Chemicals Using EPA's SHEDS-Multimedia Model." Isaacs, K., Zartarian, V., and Xue, J. Training Session, 21st Annual Conference of the International Society of Exposure Analysis, Baltimore, Maryland, October 23 – 27, 2011.

Select Publications:

  • Isaacs, K.K., Martonen, T.B, and Schlesinger, R. Three-dimensional computational fluid dynamics simulations of particle deposition in the tracheobronchial tree. J Aerosol Med. 19(3):344-52, 2006.
  • Isaacs, K.K. and Martonen, T.B. A model of particle deposition in children’s lungs: theory and experiment. J. Aerosol Med.18 (3):337-53, 2005.
  • Isaacs, K.K., Evans, M.V. and Harris, T.R. Visualization-based analysis for a mixed-inhibition binary PBPK model: Determination of inhibition mechanism. J Pharmacokinet Pharmacodyn. 31(3): 215-42, 2004.

Published & Presented Research (1999-Present)

Contact Info:
Kristin K. Isaacs
Human Exposure & Atmospheric Sciences Division
National Exposure Research Laboratory
US EPA Office of Research and Development
109 TW Alexander Drive
Research Triangle Park, NC 27709
Telephone: 919-541-2785
Email: Isaacs.kristin@epa.gov

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