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Exposure Research

Human Exposure & Atmospheric Sciences Staff

Mark J. Strynar

Title: Physical Scientist

EPA Division: Human Exposure and Atmospheric Sciences Division

EPA Branch: Methods Development and Application Branch

Narrative:
Mark’s expertise is the development of methods for the detection of xenobiotic compounds, in particular perfluorinated compounds (PFCs) in complex environmental and biological matrices. Emphasis has been placed on providing EPA and collaborating researchers with methods for the detection and analysis of PFCs in samples for use in health effects studies to support risk assessment (NIEHS/NHEERL) and for determination of environmental PFC contamination to meet agency needs (OPPT/Region 4). With proper validated methods in place an assessment of dosed animal models has been possible for PFOS and PFOA. In part, provisional health advisories for PFOS and PFOA in drinking water (OW) and fish consumption advisories (State of MN) have been possible due to methods and data Mark has generated. Developed methods have and will continue to be applied to assess potential routes of human exposure to PFCs to reduce uncertainty associated with these exposures. Recent investigations include development of TOFMS methods for the discovery of biomarkers of exposure to xenobiotic compounds in dosed rodent tissues, and exploration of unique biomarkers in matched human serum/urine.

Education/Training:

  • Ph.D., Soil Science, The Pennsylvania State University, 2003
  • M.S., Soil Science, Texas A&M University, 1997
  • B.S., Soil and Water Resource with High Distinction, The University of Rhode Island, 1993

Professional Experience:

  • Physical Scientist, USEPA, ORD, NERL-HEASD-MDAB, 2005-present
  • Postdoctoral Researcher, USEPA, ORD, NERL-HEASD-MDAB, 2002-2005

Select Awards and Honors:

  • USEPA IOAA Bronze Medal, Interdisciplinary Scientific Team for Perfluorinated Chemicals Research and Assessment, In recognition of exceptional leadership and scientific contributions in working as an interdisciplinary team to identify and address the scientific issues related to perfluorinated chemicals, 2011
  • USEPA Level III Scientific and Technological Achievement Awards (STAA) Award, “Innovative modeling of perfluooctanoic acid to bridge animals and humans for study design and risk assessment,” 2010
  • USEPA “Honor Award for Exceptional/Outstanding ORD Technical Assistance to the Regions or Program Offices; National Environmental Research Laboratory; Perfluorinated Chemicals (PFC) Water Contamination Team. “In recognition of outstanding and timely technical support to address a perfluorinated chemicals water contamination issue potentially impacting public health in EPA Region 4,” 2009
  • USEPA Level III Scientific and Technological Achievement Awards (STAA) Award “A Team Contribution to Understanding the Molecular Mechanisms of PFOA and PFOS-Induced Developmental Toxicity,” 2009
  • USEPA Level II Scientific and Technological Achievement Awards (STAA) Award “Establishing a World-Class Method Development Laboratory for Analyzing PFOS, PFOA, and Perfluorinated Compounds,” 2009
  • USEPA “Honor Award Bronze Medal” for the development and establishment of new methods to measure perfluorinated compounds in environmental and biological media, 2009
  • USEPA “S” and “T” Award Special Accomplishments Recognition Award – Team Award for help in analysis of perfluorinated compounds in Decatur, AL water samples, 2009
  • USEPA Level I Scientific and Technological Achievement Awards (STAA) Award “A Team Contribution to the Understanding of Early-Life Health Effects Following Perinatal Exposure to PFOA in Mice,” 2008
  • USEPA/ORD “Honor Award Bronze Medal” for the Perfluorinated Chemical Research Team, 2006
  • USEPA “S” and “T” Award Special Accomplishments Recognition Award – Team Award, 2006
  • USEPA, Team Accomplishment Recognition Award, PFOS/PFOA team, 2005
  • USEPA, Award Superior Accomplishment Recognition, 2004
  • USEPA Award for volunteering for the EPA/Shaw University Research Apprenticeship Program, 2004

Select Presentations:

  • Mark Strynar1, Sonia Dagnino2, Andrew Lindstrom1, Erik Andersen1, Larry McMillan3, Michael Thurman4, Imma Ferrer4, Carol Ball5 Identification of novel polyfluorinated compounds in natural waters using accurate mass TOFMS Invited to present at SERMACS November 16th, 2012 in Raleigh NC
  • Mark J. Strynar Andy Lindstrom, Amy Delinsky, Larry McMillan, Shoji Nakayama, Philip Bost PFAAs in various environmental and biological media (2011) November, 16th, 2010 University of North Carolina
  • Mark Strynar, Andy Lindstrom, Phillip Bost, Larry McMillan, Shoji Nakayama, Amy Delinsky, (2010) PFAAs in environmental and biological media PFAA Days III US EPA-RTP, NC June 8-10, 2010.
  • Mark Strynar, Dave Ehresman, Mary Kaiser, and Shoji Nakayama (2010) Perfluorinated Compound Analytical Focus Group PFAA Days III June 8-11, 2010
  • Mark J. Strynar (2009) Analysis of perfluorinated compounds in environmental and biological media. North Carolina State University. Department of Environmental and Molecular Toxicology September 8th, 2009
  • Amy Delinsky, Mark Strynar, Shoji Nakayama, Jerry Varns, and Andrew Lindstrom (2009) LC/MS/MS Determination of Perfluorinated Compounds (PFCs) in Multiple Fish Species from Two North Carolina Rivers. Presented at the National Institute for Standards and Technology (NIST) Charleston, SC January 10, 2009.

Select Publications:

  • Application of a method for the analysis of perfluorinated compounds in surface soils. Mark J. Strynar, Andrew B. Lindstrom, Shoji F. Nakayama, Peter Egeghy, and Laurence Helfant. Chemosphere 86 (2012) 252–257.
  • Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice.Zhao Y, Tan YS, Strynar MJ, Perez G, Haslam SZ, Yang C. Reprod Toxicol. 2012 Jul;33(4):563-76. Epub 2012 Mar 5.
  • Perflurooctanoic acid induces developmental cardiotoxicity in chicken embryos and hatchlings. (2011) Qixiao Jiang, Robert M. Lust, Mark J. Strynar, Sonia Dagnino, and Jamie C. DeWitt.
  • Polyfluorinated Compounds: Past, Present, and Future (2011) Andrew B. Lindstrom, Mark J. Strynar, and E. Laurence Libelo ES&T dx.doi.org/10.1021/es2011622
  • Comparative pharmacokinetics of perfluorononanoic acid in rat and mouse_Katoria Tatum-Gibbs, John F. Wambaugh, Kaberi P. Das, Robert D. Zehr, Mark J. Strynar, Andrew B. Lindstrom, Amy Delinsky, Christopher Lau, Toxicology 281 (2011) 48–55
  • Relative importance of wastewater plants and non-point sources of perfluorinated compounds to Washington state rivers. Furl C., C. Meredith, M. Strynar and S. Nakayama. Science of the Total Environment 409 (2011) 2902-2907

Published & Presented Research (1999-Present)

Contact Info:
Mark J. Strynar
Human Exposure & Atmospheric Sciences Division
National Exposure Research Laboratory
US EPA Office of Research and Development
109 TW Alexander Drive
Research Triangle Park, NC 27709
Telephone: 919-541-3706
Email: strynar.mark@epa.gov

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