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Exposure Research

Human Exposure & Atmospheric Sciences Staff

Yumei Cecilia Tan

Title: Research Physical Scientist

EPA Division: Human Exposure and Atmospheric Sciences Division

EPA Branch: Exposure and Dose Research Branch

Narrative:
Yumei has research experience in environmental engineering, occupational health and safety, human health assessment, and computational modeling. Her recent research focuses on applying exposure and pharmacokinetic/physiologically-based pharmacokinetic (PBPK) modeling in interpreting human biomarker data (chemical or metabolite concentrations). These models link exposure concentrations to internal doses by incorporating information on exposure scenarios and pharmacokinetics. In addition to biomarker research, she has applied PBPK modeling and biologically based dose response modeling to assess human health risk for environmental chemicals with different biological half-lives, such as chlorform, carbaryl, perfluorooctylacids, acetaldehyde, formaldehyde, siloxanes, and chromium.

Education/Training:

  • Ph.D., Environmental Sciences & Engineering, University of North Carolina at Chapel Hill, 2001
  • M.B.A., Biosciences Management & Financial Management, North Carolina State University, 2009
  • M.S., Environmental Sciences & Engineering, Harvard School of Public Health, 1997
  • B.S., Environmental Engineering, National Cheng Kung University, Taiwan, 1995

Professional Experience:

  • Research Physical Scientist, USEPA, ORD, NERL-HEASD-EDRB, RTP, NC 2009-present
  • Associate Director/Research Investigator, Center for Human Health Assessment, The Hamner Institutes for Health Sciences, RTP, NC 2004-2009
  • Post-doctoral Fellow, CIIT Centers for Health Research, RTP, NC 2001-2004
  • NIOSH Trainee, The University of North Carolina at Chapel Hill, Chapel Hill, NC 1997-2001
  • Industrial Hygienist, Massachusetts Institutes of Technology, Cambridge, MA 1996-1997

Professional Societies and Affiliations:

  • Society of Toxicology

Select Awards and Honors:

  • NERL Goal 5 Team Award: Anticipated Future Environmental Issues, 2009
  • NERL Goal 1 Team Award: Support the Agency’s Mission, 2010
  • ORD Bronze Medal for Commendable Service, 2012

Select Publications:

  • Tan, Y., Clewell, H., Andersen, M. “Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis” Toxicol. Lett. 177: 38-47, 2008.
  • Clewell, H., Tan, Y., Campbell, J., Andersen, M. “Quantitative interpretation of human biomonitoring data” Toxicol. Appl. Pharmacol. 231: 122-133, 2008.
  • Nong, A., Tan, Y., Krolski, M., Wang, J., Lunchick, C., Conolly, R., Clewell, H. “Bayesian calibration of a physiologically based pharmacokinetic/pharmacodynamic model of carbaryl cholinesterase inhibition” J. Toxicol. Environ. Health A 71: 1363-1381, 2008.
  • Tan, Y., Liao, K., Clewell, H. “Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling” J. Expo Sci Environ Epidemiol 17: 591-603, 2007.
  • Liao, K., Tan, Y., Clewell, H. “Development of a screening approach to interpret human biomonitoring data on volatile organic compounds: reverse dosimetry on biomonitoring data for trichloroethylene” Risk Anal. 27(5): 1223-1236, 2007.
  • Liao, K., Tan, Y., Conolly, R., Borghoff, S., Gargas, M., Andersen, M., Clewell, H. “Bayesian estimation of pharmacokinetic and pharmacodynamic parameters in a mode-of-action based cancer risk assessment for chloroform” Risk Anal. 27(6), 1535-1551, 2007.

Published & Presented Research (1999-Present)

Contact Info:
Yumei Cecilia Tan
Human Exposure & Atmospheric Sciences Division
National Exposure Research Laboratory
US EPA Office of Research and Development
109 TW Alexander Drive
Research Triangle Park, NC 27709
Telephone: 919-541-2542
Email: tan.cecilia@epa.gov

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