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Long-Term Goal 1 (LTG 1): Research Descriptions and Posters

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Back to 2009 Peer Review

Determine utility of emerging technologies in risk assessment
Research Description	Poster #	Presenter(s)
Application of Toxico-omics to Improving Risk Assessments - Mode of Action of Conazoles	LTG 1-01 (PDF) (1 pg, 722KB)	S. Nesnow and S.-F. Thai (NHEERL)
Use of Toxico-omics to Discriminate Conazoles and Related Chemicals from Phenobarbital for Human Relevancy Determinations in Cancer Risk Assessments	LTG 1-02 (PDF) (1 pg, 859KB)	S. Nesnow and S. Hester (NHEERL)
Develop MOA data for reproductive and developmental risks
Cellular and molecular modes responsible for induction of birth defects	LTG 1-03 (PDF) (1 pg, 2.6MB)	Sid Hunter (NHEERL)
Linking an in vivo pregnancy loss model to an in vitro placental cell system to explore the mode of action of disinfection byproducts	LTG 1-04 (PDF) (1 pg, 652KB)	Michael G. Narotsky (NHEERL)
The Effects of Environmental Chemicals on Neuroendocrine Function: Mode and Mechanism for Adverse Outcomes	LTG 1-05 (PDF) (1 pg, 1.1MB)	Ralph Cooper, Susan Laws and Tammy Stoker (NHEERL)
Identify PK/PD issues underlying uncertainties for extrapolation
How Does ORD Research on MOA Contribute to the Human Health Risk Assessment for PBDE Mixtures?	LTG 1-06 (PDF) (1 pg, 981KB)	Prasada Kodavanti (NHEERL)
Mode of action research of arsenic-induced tumors and toxicity	LTG 1-07 (PDF) (1 pg, 945KB)	Kirk Kitchin (NHEERL)
Arsenical Metabolism and Dosimetry: The Bridge Between Arsenic Exposure and Health Effects	LTG 1-08 (PDF) (1 pg, 1.3MB)	David J. Thomas, Elaina M. Kenyon, and Hisham El-Masri (NHEERL)
Develop MOA for oxidative stress in cancer and noncancer risk assessments
Progress toward the use of oxidative stress as a broadly applicable key event in environmental toxicity	LTG 1-09 (PDF) (1 pg, 1.1MB)	Gary Hatch and Prasada Kodavanti (NHEERL)
Future applications of Oxidative and other Stress Pathway assays to Mode of Action Studies	LTG 1-10 (PDF) (1 pg, 1.4MB)	Ram Ramabhadran, Steve Simmons and Gary Hatch (NHEERL)
Establish systems-based models for use in risk assessments
Systems Biology and Toxicity Testing in the Twenty-first Century	LTG 1-11 (PDF) (1 pg, 1.1MB)	Stephen Edwards (NHEERL) and Jerry Blancato (NCCT)
Development of Virtual Tissue Models	LTG 1-12 (PDF) (1 pg, 823KB)	Michael DeVito (NHEERL) and Imran Shah (NCCT)
Development and Use of Biologically-Based Dose Response (BBDR) Models	LTG 1-13 (PDF) (1 pg, 693KB)	Hisham El-Masri (NHEERL) and Rory Conolly (NCCT)
Constructing a Biologically-based Dose Response (BBDR) Model to Refine Risk Assessment Approaches to Respiratory Effects from Inhaled Reactive Gases: Chlorine	LTG 1-14 (PDF) (1 pg, 810KB)	Annie M. Jarabek (NHEERL/NCEA)

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