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HPV Chemical List History

Note: EPA no longer updates this information, but it may be useful as a reference or resource



October 9, 1998

The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. The U.S. HPV chemicals were identified through information collected under the Toxic Substances Control Act (TSCA) Inventory Update Rule (IUR). Organic chemicals that are manufactured in, or imported into, the United States in amounts equal to or exceeding 10,000 pounds per year are subject to reporting under the TSCA IUR. Reporting is required every four years.

The HPV Challenge Program Chemical List consists of all the HPV chemicals reported during the 1990 IUR reporting year. Inorganic chemicals and polymers, except in special circumstances, were not subject to the IUR reporting requirements although a number were reported in error. The HPV Challenge Program Chemical List contains about 2,800 chemicals.

The 1990 IUR list was selected as the starting point for this program. As subsequent reporting years identify additional chemicals (including inorganics, once the corresponding reporting requirements have been added under the IUR), they will be posted here for information purposes. EPA expects that, over time, the testing of new HPV chemicals will become routine, and companies may wish to test new HPV chemicals as they appear.

In keeping with that eventual goal, EPA is posting the 1994 IUR List of HPV Additions, which contains about 500 organic HPV chemicals which were newly reported as HPV in the 1994 IUR and are thus not part of the HPV Challenge Program at this time. This list is being provided particularly for use by companies who desire to propose categories of chemicals for testing and wish to include chemicals from the 1994 list in their category definitions.

Each HPV chemical list is provided in database format. The database tables contain one record per chemical. Each record contains three fields. The first field (CASNO) contains the Chemical Abstract Services registry number, which is a unique identification number assigned to a chemical. The second field (INDICATOR) is an indicator variable that, if greater than 0, signifies that the chemical falls outside the scope of the HPV Challenge Program. The possible values for the indicator and their corresponding reasons for falling outside the scope of the program are:

beaker.gif  1 = Chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties, or

beaker.gif  2 = Chemical is otherwise being handled under the Organisation for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Finally, the name of the chemical is found in the last field (CHEMICAL).

December 9, 1998

The scope of the HPV Challenge Program does not include testing of polymers and inorganic chemicals. These substances were excluded from the reporting requirements of the Inventory Update Rule (IUR) of 1986 unless regulated by a TSCA Section 4, 5(a)(2), 5(b)(4) or 6 rule or an order under Section 5(e) or 5(f), as stipulated under 40 CFR 710.26. To maintain consistency within the HPV Challenge Program, however, the Agency decided it would not include any polymers or inorganics in the program. Since the HPV Challenge Program Chemical List was derived from the 1990 IUR, it was expected that only a minimal number of these substances would be on the list, and that, in most cases, those inclusions would be the result of misreporting by individual companies.

In preparing the HPV Challenge Program Chemical List, the Agency reviewed the original 1990 IUR list of HPV chemicals for polymers and inorganics (misreported and appropriately reported). This review utilized a computer algorithm that, as noted by the Agency in the preamble to the 1986 IUR, would not identify all polymers and inorganic substances on the list, due to the highly complex nature of the CAS nomenclature rules and the lack of a complete molecular formula for many of the Class 2 substances on the TSCA Inventory. Because of the limitations of the screening algorithm, some polymers and inorganic chemicals did escape the automatic search and did appear on the first HPV Challenge Program Chemical List, which was published on October 9, 1998.

In response to questions regarding the polymers and inorganics that appeared on the initial HPV Challenge Program Chemical List, the Agency conducted a comprehensive manual review of the list. A similar exercise was conducted on the 1994 IUR List of HPV Additions. As a result of this effort, additional polymers and inorganic substances have been identified and removed from the scope of the HPV Challenge Program.

To avoid any potential confusion from having multiple lists of HPV Challenge Program chemicals, the Agency is not removing these chemicals from the original list, but rather is marking them with an indicator of "3" to denote that these chemicals are not included in the HPV Challenge Program. The description of this indicator reads:

beaker.gif  3 = Chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.

A few Class 2 substances and pigments, which may be polymers or inorganics, may remain on the HPV Challenge Program Chemical List because the name and/or definition provided by the original submitter to the TSCA Inventory lacked conclusive information on which to determine whether the chemical was a polymer or inorganic substance. In the absence of additional definitive information, those substances were left on the HPV Challenge Program Chemical List.

Although the HPV Challenge Program Chemical List was developed using Inventory Update Rule submissions, the removal of chemicals from the scope of the HPV Challenge Program does not necessarily mean that they are excluded from current or future IUR reporting. All questions concerning whether a chemical is subject to IUR reporting should be submitted to the Agency as described in the IUR Instruction Manual (http://www.epa.gov/opptintr/iur98).

May 20, 1999

The Agency has updated the HPV Challenge Program Chemical List to add an indicator of "2" to sixteen additional chemicals, as these chemicals are otherwise being handled under the OECD HPV SIDS Program. Fourteen of these chemicals were selected in the latest phase of the OECD SIDS chemical selection process (Phase 7), completed in February, 1999. The remaining two chemicals were already in the SIDS Program but had not been identified on the previous HPV Challenge Program Chemical List. The sixteen additional chemicals, listed by CAS number, are:

85416 88448 88608 89725
91769 93685 98920 99047
101837 118796 119471 126330
141979 611198 16219753 34590948

July 27, 1999

The HPV Challenge Program Chemical List and 1994 List of HPV Additions have been updated to add a column entitled Sponsorship Status. This indicator identifies the 1990 and 1994 HPV chemicals which have been sponsored under the HPV Challenge Program as of July 19, 1999. Sponsored chemicals are identified by an "F" for fully sponsored, a "P" for provisionally sponsored, or an "N" for Not Sponsored under the HPV Challenge Program.

Please note that sponsorship status has been indicated only for those chemicals appearing on the HPV Challenge Program Chemical List or on the 1994 List of HPV Additions. A complete list of sponsored chemicals, including those chemicals which are not on either of the above-mentioned lists, can be found on our Sponsored Chemicals page.

The key is as follows:


Indicator Values

beaker.gif  0 = Chemical is a candidate for sponsorship under the HPV Challenge Program

beaker.gif  1 = Chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties

beaker.gif  2 = Chemical is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program

beaker.gif  3 = Chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.


Sponsorship Status Values

beaker.gif  F = Fully Sponsored

beaker.gif  P = Provisionally Sponsored

beaker.gif  N = Not Sponsored
The Sponsorship Status Column will be periodically updated as commitments are received by the Agency. In addition, a link to the actual letters received by sponsor will be added at a later date.

Changes made on October 27, 1999:

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to add a new column identifying the companies or consortia that have submitted full or provisional commitments to EPA to sponsor chemicals under the HPV Challenge Program. The lists reflect responses received through the close of business on October 15, 1999. The Agency has also updated the lists to reflect changes to chemical sponsorship under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

If you have any questions concerning this list, please submit them using the comment button located at the bottom of this page.

Sponsor Commitment Status Column

Companies or consortia that have submitted full or provisional commitments to EPA to sponsor chemicals under the HPV Challenge Program are identified in a new column entitled Sponsor Commitment Status. In addition to the company or consortium name, an "F" or "P" is shown in brackets, indicting whether the commitment is full or provisional. Consortia member companies are not listed. Please consult the HPV Challenge Summary Report to learn which companies or organizations are members of a particular consortium (
www.epa.gov/chemrtk/sumresp.htm). The start year for the chemical is also included in this column.

In this column, "F" and "P" refer specifically to the commitment of a company or consortium to sponsor a particular chemical. The "F" or "P" shows whether the company or consortium has provided all or only part of the required elements for a commitment to the Program. This differs from the "F" and "P" found in the Chemical Sponsorship Status column.

Chemical Sponsorship Status Column

The "F" and "P" found in the Chemical Sponsorship column refer to the status of a chemical in the HPV Challenge Program. A chemical is fully sponsored if the Agency has received at least one full commitment from a company or consortium. A chemical is provisionally sponsored if the Agency has received at least one provisional commitment, but no full commitments, from a company or consortium.

A description of what constitutes full and provisional commitments and fully and provisionally sponsored chemicals can be found in the section on "How to Use the Lists."

Both the Chemical Sponsorship Status and the Sponsor Commitment Status columns will be updated weekly as commitments are received by the Agency. In addition, a link to the actual letters submitted or received by sponsors will be added at a later date. The Sponsor Commitment Status column is not yet searchable, and data from that column will not appear in searches performed using the other indicators available on the list. The Agency is currently modifying the search function to allow searches using data in this column, and when that search capability becomes available, the Agency will provide notification on the "What's New" page.

The Agency recognizes that some chemicals are sponsored by more than one company or consortium. In these cases, the Agency suggests that the companies or consortia coordinate sponsorship of the particular chemical to avoid duplication of effort and ensure costs are minimized. When multiple companies or consortia submit commitments covering the same chemical, the Agency contacts all of the sponsors to alert them to the duplication and to encourage coordination of effort.

SIDS Chemicals

The Agency has updated the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to add an indicator of "2" to thirteen chemicals. The "2" indicator denotes chemicals that are otherwise being handled under the OECD HPV SIDS Program. Eight of these 13 chemicals were selected in the latest phase of the OECD HPV SIDS chemical selection process. The chemicals were nominated by sponsor countries at the SIDS Initial Assessment Meeting held in Paris, France June 29-30, July 1, 1999. The remaining five chemicals (74-87-3, 111-41-1, 135-19-3, 4461-52-3, and 20324-32-7) are also in the SIDS Program and were nominated at other times. Twelve of the 13 chemicals are on the HPV Challenge Program Chemical List. The remaining chemical is on the 1994 List of HPV Additions. The thirteen chemicals, listed by CAS number, are:

74-87-3 111-41-1 839-90-7 25321-09-9
80-09-1 123-11-5 1330-20-7
94-36-0 135-19-3 4461-52-3
98-51-1
(1994 list)
793-24-8 20324-32-7  


Additionally, the indicator "2" was removed from two chemicals (25640-78-2 and 26896-20-8), as these chemicals are no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program.

The HPV Challenge Program Chemical List and the 1994 List of HPV Additions are provided below for downloading in two forms, DBF and Portable Data Format (PDF). While the content of the lists in DBF and PDF format are the same, the DBF versions include more records than the PDF versions. With the PDF versions, the CAS number is listed only once for all companies and consortia that are sponsoring that chemical. With the DBF versions, the CAS number is repeated for each sponsor. Repeating the information allows users to sort the file by something other than CAS number. A key to the various values used in the lists can be found on the "How to Use the Lists" page.

November 5, 1999

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on October 29, 1999.

November 10, 1999

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 5, 1999. Additionally, an indicator of "2" was added to CAS No. 77-92-9 indicating that this chemical is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program. An indicator of "3" was added to CAS No. 11097-59-9 indicating that this chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.

November 17, 1999

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 12, 1999.

November 30, 1999

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 26, 1999. If you have any questions concerning these lists, please submit them using the comment button located at the bottom of this page.

March 7, 2000

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on March 3, 2000. This update captures all commitments received by the close of the voluntary sign-up period on December 1, 1999.

An indicator of "2" was added to CAS Nos. 95-50-1, 106-42-3, 624-41-9, and 25376-45-8, indicating that these chemicals are otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Three new codes were added to the list during this update, two numerical ones in the "Indicator" column and one letter code in both the "Chemical Sponsorship Status" and the "Sponsor Commitment Status" columns. These new codes are:

Indicator Column Values:

beaker.gif  4 = A company or consortium has clearly indicated to and has had confirmed by ICCA their sponsorship of this chemical in the Global HPV Initiative of the International Council of Chemical Associations, and all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) has been provided to the Agency.

beaker.gif  5 = Chemical meets the criteria for being "No Longer HPV" and is thus no longer subject to the HPV Challenge Program. This chemical may be sponsored.
June 16, 2000

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on May 26, 2000. This update captures all commitments received by the close of the voluntary sign-up period on December 1, 1999. Letters received since December 1, 1999 reflect clarifications to previously submitted commitments. As of today, no new commitments have been received.

An indicator of "2" was added to CAS Number 8007189 indicating that this chemical is otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Ind = 2
8007189
An indicator of "5" was added to the CAS Numbers below indicating that these chemicals meet the criteria for being "No Longer HPV" and are no longer subject to the HPV Challenge Program. These chemicals may be sponsored
 
Ind = 5
101633 534156 619669 824782 1300738 2738069
13188608 13360639 21729986 35884663 68308678


December 15, 2000

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on December 1, 2000. This update captures all commitments received by close of the voluntary sign-up period on December 1, 1999. Letters received since December 1, 1999 generally reflect clarifications to previously submitted commitments.

The International Council of Chemical Associations (ICCA) HPV commitments have also been updated at this time
Indicator Column Values:

beaker.gif  0 = Chemical is a candidate for sponsorship under the HPV Challenge Program

beaker.gif  1 = Chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties

beaker.gif  2 = Chemical is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program

beaker.gif  3 = Chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.

beaker.gif  4 = A company or consortium has had confirmed by the International Council of Chemical Associations (ICCA) their sponsorship of this chemical in the HPV Initiative of ICCA, and all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone) has been provided to the Agency.

beaker.gif  5 = Chemical meets the criteria for being "No Longer HPV" and is thus no longer subject to the HPV Challenge Program. This chemical may be sponsored, however.
  An indicator of "1" was added to the CAS Numbers below indicating that these chemicals are not considered candidates for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties. These chemicals may be sponsored, however.

Ind = 1

142472      65996636      65996647

  An indicator of "2" was added to the CAS Numbers below indicating that these chemicals are otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Ind = 2

78795 95498 96311 96333 97632 97869
99990 100549 103764 106638 106887 106989
107153 108316 108996 109068 110861 110985
111900 112072 112152 112254 112572 122521
122996 123546 124174 140318 140885 141106
141322 143226 301100 513359 556821 584849
616386 683181 753731 770354 818086 993168
1461229 1461252 1559348 3290924 3590849 5102830
5131668 5567157 6358856 6881943 13048334 15625895
20324338 23783428 25498491 26471625 29911282 42978665
57583343 57583354 63449398 68515935 68784269 68815678
68855458 68909182 72275866 73758620    


  An indicator of "5" was added to the CAS Numbers below indicating that these chemicals meet the criteria for being "No Longer HPV" and are no longer subject to the HPV Challenge Program. These chemicals may be sponsored, however.

Ind = 5

54217 85698 89087 94746 132274 139026
554121 616217 13927770 28984896 68476482 68477225
68609643          


Chemical Sponsorship Status Column Values:

beaker.gif  I = ICCA Confirmed Commitment

Company or consortium has clearly indicated to and has had confirmed by ICCA their sponsorship of a chemical(s) in the HPV Initiative of the International Council of Chemical Associations.

All confirmed Company and Consortium ICCA commitments are identified in a letter to EPA's Administrator from ICCA dated August 4, 2000. This letter supercedes the earlier ICCA letter dated February 25, 2000.

Companies can meet the requirements of the HPV Challenge Program either directly through the Challenge Program or indirectly through the OECD HPV SIDS Program and/or the ICCA HPV Initiative. U.S. companies deciding to sponsor chemicals under the HPV Challenge Program can also identify those chemicals as U.S. contributions to the OECD HPV SIDS Program and/or the ICCA HPV Initiative. Such chemicals may have both an "I" (confirmed ICCA sponsorship) and an "F" (Full sponsorship or fully sponsored HPV Challenge Program Commitment) in the Sponsor Commitment Status field.

It is noted that a chemical with confirmed sponsorship under the ICCA HPV Initiative may not be listed with a "4" in the indicator column. All data elements necessary for Full Commitment status under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) must also be provided to the Agency in order for the chemical to be designated as an ICCA sponsored chemical under the HPV Challenge Program (and thus receive a "4" in the indicator column.

October 12, 2001

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on July 13, 2001. This update generally reflects clarifications or changes to previously submitted commitments.

These updated lists also reflect changes to the following Indicator Column Values:

Indicator = 1

  An indicator of "1" was added to the CAS Numbers below indicating that these chemicals are not considered candidates for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties. These chemicals may be sponsored, however.

59029      68334281      68918423     68989980


Indicator = 2

  An indicator of "2" was added to the CAS Numbers below indicating that these chemicals are otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

HPV Challenge Program Chemical List:
50000 105602 124403 7659861 64742489
56815 105646 128370 8032324 64742490
58082 106310 134203 8052413 64742810
65850 107415 137326 13674878 64742821
68111 107926 139333 13952846 64742887
68122 107960 139899 15708415 64742898
71410 108112 140012 16111629 64742945
74895 108189 142825 16470249 64742956
75014 108214 142847 16485475 64771728
75047 108394 142905 18328900 66455172
75310 108678 287923 18719034 67762258
75387 108918 528449 20824560 67762270
75503 109524 532321 21265509 67762305
75649 109604 538932 22473785 67762418
75683 109739 540841 25103097 67859512
77474 109831 544763 25155253 68333802
78637 109897 552307 25264931 68390567
78784 110054 582252 25339564 68410968
78922 110190 598561 25377837 68410979
78966 110543 614459 25550145 68476506
79094 110623 629505 25584832 68477316
79312 110918 629629 26523784 68516187
79345 111273 629732 26748414 68527059
79947 111659 629969 27215958 68551166
80159 111842 661198 29964849 68551177
80433 111864 818611 30618849 68551199
88733 111875 822060 32360057 68551202
88744 111922 927071 36653824 68603156
90722 112301 1222055 38051104 68603178
95658 112403 1321944 45294186 68911615
96059 112425 1338234 61788452 70024929
96184 112709 1704627 61788463 70693060
97723 112721 1761713 63393828 70955112
97858 112889 2050922 64741635 75782864
98942 112903 2495274 64741657 75782875
100378 116530 2549533 64741737 90622461
100516 121448 2935902 64741840 93924073
102067 121915 3006824 64741851 129813678
102829 123057 3033623 64741919
103093 123626 5332730 64742069
104756 123966 5421465 64742467
105599 124301 7534943 64742478


1994 List of HPV Additions:
58559 107835 1939362 3425614 19910657
107711 1717006 2495252 6140745 25378227


Additionally, the indicator "2" was removed from the following chemical, as this chemical is no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program:

4461523


Indicator = 4

  No new Indicator "4"s have been added to the list. All confirmed Company and Consortium International Council of Chemical Associations (ICCA) commitments are identified in a letter to EPA's Administrator from ICCA dated August 4, 2000. This letter supercedes the earlier ICCA letter dated February 25, 2000.

Indicator = 5

  An indicator of "5" was added to the CAS Numbers below indicating that these chemicals meet the criteria for being "No Longer HPV" and are no longer subject to the HPV Challenge Program. These chemicals may be sponsored, however.


62544 107562 118296 141526 141980 693210
1497683 2738069 4356609 6423434 13393936 13889924
17564646 18169578 25037450 32131172 36876138 39464705
52836314 55701058 61790350 68308678 68443856 73467773


The following Values were added to the Sponsor Commitment Status Column:

V = Viable Commitment. Same as Full Commitment but the commitment to sponsor the particular chemical was received after the December 26, 2000 proposed test rule was published (65 FR 81658). In addition to meeting the standard requirements of the HPV Challenge Program, sponsors must also provide full copies of studies for viable chemicals.

Q = Provisional Viable Commitment. Same as Provisional Commitment (all the required commitment information was not provided.) but the commitment to sponsor a particular chemical was received after the December 26, 2000 proposed test rule was published (65 FR 81658). Provisional viable commitments will be upgraded to Viable status (see above) upon receipt and processing of required commitment information.

V = Viable-Sponsored Chemical. The Agency has received at least one viable commitment from a company or consortium to sponsor the particular chemical.

Q = Provisional Viable-Sponsored Chemical. Company/Consortia has provided most, but not all, of the Viable Commitment information. The Agency has received at least one provisional viable commitment, but not viable commitments, from a company or consortium to sponsor the particular chemical.

A = Test Rule Chemical. Chemicals listed in the proposed "Testing of Certain High Production Volume Chemicals; Data Collection and Development on High Production Volume (HPV) Chemicals" rule (65 FR 81658). These chemicals may be sponsored prior to publishing a final rule. Note that sponsorship after the December 26, 2000 date (a viable commitment) requires that, in addition to meeting the standard requirements of the HPV Challenge Program, sponsors also provide full copies of studies.

C = Voluntary Children's Chemical Evaluation Program Chemical. Chemicals listed in the Voluntary Children's Chemical Evaluation Program notice (64 FR 81699). These chemicals may be sponsored. Note that sponsorship after the December 26, 2000 date (a viable commitment) requires that, in addition to meeting the standard requirements of the HPV Challenge Program, sponsors also provide full copies of studies.

March 13, 2002

In some cases, companies or consortia have sponsored chemicals that are not on either the HPV Challenge Program Chemical List or the 1994 List of HPV Additions. A list of these chemicals, called "Additional Chemicals Sponsored Under the HPV Challenge Program" is being added with this update. The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on January 18, 2002. This update generally reflects clarifications or changes to previously submitted commitments.

These updated lists also reflect changes to the following Indicator Column Values:

Indicator = 1

  No new indicators of "1" were added to the list. A "1" indicates that the chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties. A chemical with an indicator of "1" may be sponsored, however.

Indicator = 2

  An indicator of "2" was added to the CAS Numbers below indicating that these chemicals are otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

CAS Number

CAS Number

CAS Number

CAS Number

CAS Number

75763

75945

78104

80104

98135

107186

107460

108463

108985

115219

124709

131179

527071

540976

541026

541059

675627

872504

919302

919313

999973

1066359

1067534

1185553

1310583

1310732

1313139

1322981

1760243

2487903

2530838

2530872

2550063

4253343

4518983

7351613

7447407

7647010

7778543

7782505

10025782

10026047

10043524

11099062

12125029

13528886

17689779

22984549

27636755

85117506



Additionally, the indicator "2" was removed from the following chemical2, as these chemicals are no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program:


95658     20324327


Indicator = 4

  Based on the January 31, 2002 letter from ICCA, new Indicator "4"s have been added to the list. All confirmed Company and Consortium International Council of Chemical Associations (ICCA) commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000 and January 31, 2002. These letters supercede the earlier ICCA letter dated February 25, 2000.

Indicator = 5

  No new indicator "5"s were added to the lists. A "5" indicates that the chemical meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program. A chemical with an indicator of "5" may be sponsored, however.


May 22, 2002

The Agency has updated the HPV Challenge Program Chemical List, the 1994 List of HPV Additions and the Additional Chemicals Sponsored under the HPV Challenge Program to reflect letters received through the close of business on March, 15, 2002. This update generally reflects clarifications or changes to previously submitted commitments.


August 8, 2002

The Agency has updated the HPV Challenge Program Chemical List, the 1994 List of HPV Additions and the Additional Chemicals Sponsored under the HPV Challenge Program to reflect letters received through the close of business on July 12, 2002. This update generally reflects clarifications or changes to previously submitted commitments.

These updated lists also reflect changes to the following Indicator Column Values:

Indicator = 1

No new indicators of "1" were added to the list. A "1" indicates that the chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties. A chemical with an indicator of "1" may be sponsored, however.

Indicator = 2

No new incator "2" were added to the list. A "2" indicates that these chemicals are otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Indicator = 4

No new indicator "4" was added to the list. All confirmed International Council of Chemical Associations (ICCA) commitments are identified in documents to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002 and April 12, 2002. These letters supercede the earlier ICCA letter dated February 25, 2000.

Indicator = 2,4

An Indicator "2,4" was added to the CAS numbers below. A "2" indicates that these chemicals are otherwise being handled under the Organizational for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program and a indicator "4" indicates that these chemicals are confirmed International Council of Chemical Associations (ICCA) commitments identified in documents to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002 and April 12, 2002. These letters supercede the earlier ICCA letter dated February 25, 2000.

Chemicals receiving new Ind=2, 4 flags
75127 3323533
78591 4454051
87569 6104309
100005 288324
106445 1312761
115071 1490046
115866 6834920
120809 7775146
603350 7791255
947046 10213793
1319773 13517243
1328536 85422920
2855132 86089170


Indicator = 5

No new indicator "5"s were added to the lists. A "5" indicates that the chemical meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program. A chemical with an indicator of "5" may be sponsored, however.

View the 1990 HPV Challenge Program Chemical List, the 1994 IUR List of HPV Additions or the Additional Chemicals Sponsored Under the HPV Challenge Program.

November 21, 2002

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemicals are otherwise being handled under the OCED SIDS program.

60242 67481 67561 75978 77587
78046 89781 97905 100709 108894
109091 109160 110894 111488 112276
112594 112607 144558 496720 497198
870086 994058 1118463 2235430 2687254
2809214 3091256 4792158 5995426 8013078
8016113 10126688 13547701 15356602 15827608
20592852 22042962 22591215 26864379 26998970
27193868 29329713 42272708 55680030 61789013
67845947 67845958 67953768 68186903 68391117
68609927 74499357 88917220 98246878 122384854
122384876 201687572      


An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS Program.

75070      75150      75218      110270      72275866


Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the August 26, 2002 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, and August 26, 2002.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added to the list.

December 18, 2002

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

110305 210555945


An indicator of "2" was removed from the following chemical as it is no longer included in the OECD SIDS Program.

27193868


Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4." All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, and August 26, 2002.

No new indicators of "4" were added to the list. Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added to the list.

March 6, 2003

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

64186 74931 75081 75661 79210
79221 79389 95476 106423 106752
107039 107313 108236 108383 109795
111886 112550 141537 142961 280579
501531 541413 544172 760678 1344009
2837890 3268493 3282302 4300974 5188078
6422862 24468131 25103586 25360105 40292828
68153300 68953582      


An indicator of "2" was removed from the following chemical as it is no longer included in the OECD SIDS Program.

1319773


Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4." All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, and August 26, 2002.

No new indicators of "4" were added to the list.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added to the list.

June 4, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

64-17-5 78-87-5

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the March 28, 2003 from ICCA, new indicators of "4" have been added to the list. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, and March 28, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

An indicator of "5" was added to the CAS numbers below.
825-90-1 1572-52-7
61791-47-7 27288-44-4

September 3, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

31570-04-4
75-00-3

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the July 14, 2003 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, and July 14, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added.

October 14, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

95-55-6 99-54-7 107-86-8 110-93-0 120-92-3
298-12-4 1300-72-7 3648-20-2 7727-21-1 7727-54-0
7775-27-1 10035-10-6 12068-03-0 26401-86-5 26401-97-8
26447-10-9 28348-53-0 32073-22-6 37475-88-0 68515-43-5
68515-47-9 69669-44-9 85507-79-5 90194-45-9 127184-52-5

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the July 14, 2003 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, and July 14, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added.

Search the HPV Challenge Program Chemical List



Please note that dashes have been added to all CAS Numbers on this website. This change ensures that all CAS Numbers conform to standard CAS format. Dashes must now be included when searching for a CAS Number.


January 22, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

78-95-5 79-77-6 80-54-6 85-44-9 98-07-7
101-54-2 106-43-4 106-49-0 107-25-5 109-53-5
109-92-2 111-36-4 119-64-2 124-04-9 139-96-8
764-41-0 868-85-9 1309-37-1 1317-61-9 1653-19-6
2235-54-3 4098-71-9 5124-30-1 5324-84-5 7719-12-2
7757-82-6 7783-20-2 9084-06-4 10025-87-3 11071-47-9
12070-12-1 16090-02-1 24549-06-2 25321-14-6 25339-17-7
27458-94-2 36290-04-7 51000-52-3 68081-96-9 68081-98-1
68153-01-5 68439-57-6 68585-47-7 70942-01-7 91078-68-1
93924-63-1 117875-77-1


An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

109-86-4 527-07-1 4300-97-4


Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the October 7, 2003 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, and October 7, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added. March 12, 2004

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

One new indicators of "1" was added to the list:

1152-61-0
Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

56-23-5 71-55-6 75-09-2 75-18-3 75-35-4
90-80-2 91-64-5 95-53-4 110-16-7 299-27-4
299-28-5 526-95-4 527-07-1    


An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

98-56-6 121-69-7 2524-03-0 2524-04-1


Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, and October 7, 2003.

No new indicators of "4" were added to the list.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added.

May 28, 2004

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

128-44-9 137-26-8 7414-83-7


An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

106-98-9 124-18-5 629-59-4 3039-83-6


Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, October 7, 2003, and May 17, 2004.

Twenty-five new indicators of "4" were added to the list.

78-51-3 80-56-8 354-33-6 372-09-8 1333-86-4
8002-26-4 8006-64-2 8016-81-7 8050-09-7 8050-15-5
8050-26-8 8050-31-5 8052-10-6 9005-90-7 61790-12-3
61790-51-0 64365-17-9 65996-96-5 65997-03-7 65997-04-8
65997-06-0 65997-13-9 68201-59-2 68938-00-1 68955-98-6


An indicator of "4" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

90-72-2 119-61-9 301-02-0 630-08-0 3048-65-5
16883-83-3 32210-23-4 34690-00-1 38051-10-4


Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

Two new indicators of "5" were added.

6842-15-5 27157-94-4


Indicator = 2, 4 (SIDS/ICCA)

An Indicator "2,4" was added to the CAS number below. A "2" indicates that this chermical is otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program and an indicator "4' indicates that this chemical is a confirmed International Council of Chemical Associations (ICCA) commitment identified in documents to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, October 7, 2003 and May 17, 2004.

One Chemical received a new Ind=2,4 flag; 5995-42-6

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