Integrated Risk Information System (IRIS)
National Research Council Review of the IRIS Assessment Development Process
Other NRC projects
related to IRIS:
- Guidance for and Review of EPA's IRIS Toxicological Assessment of Inorganic Arsenic

Start date: 7/17/2012
The National Academies' National Research Council (NRC) is conducting a comprehensive review of the IRIS assessment development process. The NRC will review the IRIS assessment development process and the changes being implemented or planned by EPA. The NRC will recommend modifications or additional changes as appropriate to improve the scientific and technical performance of the IRIS Program. The NRC's review focuses on the development of IRIS assessments rather than the review process that follows draft development. Additionally, the NRC is reviewing current methods for evidence-based reviews and will recommend approaches for weighing scientific evidence for chemical hazard and dose-response assessments.
NRC Review of the IRIS Assessment Development Process
EPA Announcement (May 16, 2012)
Start date Apr 26, 2012; project duration: 24 months
EPA Materials Submitted to the NRC
- Part 1: Status of Implementation of Recommendations (Jan 30, 2013) (PDF, 142pgs, 3.2MB)
- Part 2: Chemical -Specific Examples (Jan 30, 2013) (PDF, 47pgs, 863Kb)
If you would like to provide any comments on these materials, please use the IRIS Public Comment & Feedback Form. Please include your full name and title; company/sponsoring organization; email address; and phone number.
