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Hexavalent Chromium Workshop

UPDATE: This workshop has been held. Workshop materials will be posted as they become available.

EPA is developing an updated IRIS assessment of hexavalent chromium. This assessment will evaluate the potential health effects of hexavalent chromium from oral and inhalation exposures. An important component of determining the cancer causing potential of ingested hexavalent chromium is understanding the rates at which this metal is effectively detoxified in the gastrointestinal tract. To address this, EPA convened a state of the science workshop where an expert panel discussed this issue. This workshop was open to the public, broadcast by webinar/teleconference, and took place over two non-consecutive days.

Here is a list of workshop materials and meeting information:

Workshop Agenda

Day 1 (Thursday, September 19): Reduction, absorption, and transit of ingested hexavalent chromium in the human GI tract
The first workshop session focused on questions regarding the toxicokinetic properties of ingested hexavalent chromium that will inform estimates of the amount absorbed in unreduced form in different portions of the GI tract as a function of species and dose.

Day 2 (Wednesday, September 25): Factors affecting susceptible human populations and lifestages
The second workshop session focused on questions addressing what is currently known about how toxicokinetic processes may vary among human populations and/or lifestages and potentially impact susceptibility to hexavalent chromium-induced toxicity.

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Workshop Panelists

Co-Chair:  Elaina M. Kenyon, Ph.D.
U.S. Environmental Protection Agency
National Health and Environmental Effects Research Laboratory

Co-Chair:  Gary Ginsberg, Ph.D.
Connecticut Department of Public Health

Kim Barrett, Ph.D.
University of California, San Diego

Max Costa, Ph.D.
New York University

John Crison, Ph.D.
Bristol-Myers Squibb

Silvio DeFlora, Ph.D.
University of Genoa

Sean Hays, Ph.D.
Summit Toxicology

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Workshop Materials

Chromium VI Workshop Presentations (PDF) (66 pp, 4.54M, about PDF)

White paper on factors affecting the reduction and absorption of hexavalent chromium in the gastrointestinal (GI) tract (PDF)   (9 pp, 191Kb, about PDF)

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