Mouse Lung Tumor Workshop
UPDATE: EPA announced in December 2014 the availability of the final Workshop Summary Report (See workshop agenda tab).
EPA conducted a State-of-the-Science Workshop on Chemically-induced Mouse Lung Tumors: Applications to Human Health Assessments. The purpose of this workshop was to discuss the available data and interpretation of results from studies of mouse bronchiolar-alveolar adenomas and carcinomas (lung tumors) following exposure to chemical agents, and the relevance of such tumors in mice to human cancer risk. Several lines of research have investigated whether or not these types of lung tumors are formed by a mode of action (MOA) which is specific to mice and are relevant to tumor formation or other toxicity in humans.
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EPA's Mouse Lung Tumor Workshop (MLTW) was held from 8:30 AM - 5:00 PM eastern time on January 7-8, 2014.
US EPA Auditorium (Room C111)
109 TW Alexander Drive
Research Triangle Park, NC 27711
This two-day, state-of-the-science workshop covered a broad range of evidence from human, animal, and in vitro studies with a focus on specific chemicals (ethylbenzene, naphthalene, and styrene) causing lung tumors in mice and implicated in a proposed species-specific mode of action (MOA) based on metabolic and physiological susceptibility. The workshop was sponsored and organized by EPA with input from (1) a volunteer committee of outside experts (including representatives from academic institutions, State agencies, other Federal organizations, NGOs, and industry), and (2) an internal working group of experts from EPA and other Federal partners. The workshop included four separate sessions examining individual topic areas in detail, beginning with and continually referring back to the human relevance of data from animal and in vitro studies.
- A Session Abstracts document (PDF) (55 pp, 2.27M) was made available to provide context and define the scope for the discussions. It was also developed to provide the introductory material and facilitate a quick engagement in fruitful discussions from the very beginning of the workshop with a minimum of introductory presentations. This document of preliminary materials remains useful following the workshop.
- The Health and Environmental Research Online (HERO) literature database includes a publicly-available project page specifically for the MLTW which provides the available literature relevant to the workshop.
Workshop Goals and Scope:
The goals of the workshop:
- Identify the evidence, from multiple scientific disciplines, regarding formation of chemically-induced lung tumors in mice and how such evidence informs human health assessments.
- Identify approaches for analyzing and interpreting the evidence.
- Identify commonalities, linkages, or differences between the evidence from various disciplines.
This workshop was conducted to inform the development of assessments for chemicals where mouse lung tumors are an issue (e.g., ethylbenzene, naphthalene, styrene). EPA did not seek consensus, recommendations, or guidance during the workshop.