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IRIS Public Science Meeting (June 2014)

NOTICE: All preliminary materials, agenda, and a list of scientific issues to be discussed at the meeting, are available on the web site.

EPA has released the preliminary materials associated with the IRIS assessments of inorganic arsenic (iAs) and hexavalent chromium (Cr(VI)) for public comment and discussion. The scientific issues to be discussed at the meeting have been posted under "Meeting Materials" and meeting registration is now open. 

IRIS bimonthly public science meetings allow the public the opportunity to provide input and participate in discussions about preliminary assessment materials and draft IRIS assessments.

At the June meeting, materials related to the following chemicals will be discussed:

Note: The preliminary materials for inorganic arsenic and hexavalent chromium present study information using two very different approaches with varying levels of detail.  Inorganic arsenic is exploring the use of a modification of the draft approach developed by the NTP’s Office of Health Assessment and Translation, while hexavalent chromium is using modified approaches under development by the IRIS Program. The IRIS Program intends to evaluate how well each approach facilitates subsequent assessment development, promotes constructive public discussion, and makes efficient use of program resources.

IRIS Bimonthly Public Meeting
June 25-27, 2014

U.S. EPA Conference Center
One Potomac Yard (South Building)
2777 South Crystal Drive
Arlington, Virginia 22202

Agenda (as of June 24, 2014)

Agenda is available for download. Agenda June 25-27, 2014 Public Meeting (PDF, 4 pp, 112 Kb) - Last updated 6/24/14

Wednesday, June 25, 2014

9:00 am EDTRegistration

9:30 amWelcome, announcements, webinar logistics
  • Vincent Cogliano, EPA/IRIS
10:00 amHexavalent Chromium

Introduction
  • Catherine Gibbons and Alan Sasso, EPA/IRIS Assessment Managers
Science issue 1: Cancer classification by inhalation

Facilitated discussion of science issue with all attendees, including:
  • Max Costa, New York University Medical Center (via telephone)
  • Deborah Proctor, ToxStrategies, on behalf of Electric Power Research Institute
Science issue 2: Noncancer hazards to be considered

Facilitated discussion of science issue with all attendees, including:
  • Max Costa, New York University Medical Center (via telephone)
  • Ted Simon, Ted Simon LLC
11:45 amLunch break

12:45 pm Science issue 3: Susceptibility of mice to gastrointestinal toxicity

Facilitated discussion of science issue with all attendees, including:
  • Max Costa, New York University Medical Center (via telephone)
  • Elliot Gordon, Elliot Gordon Consulting LLC, on behalf of ToxStrategies
  • Chris Kirman, Summit Toxicology, on behalf of American Chemistry Council
  • Chad Thompson, ToxStrategies
Science issue 4: Utility of subchronic histopathological data

Facilitated discussion of science issue with all attendees, including:
  • Max Costa, New York University Medical Center (via telephone)
  • Elliot Gordon, Elliot Gordon Consulting LLC, on behalf of ToxStrategies
  • Mark Harris, ToxStrategies
  • Chad Thompson, ToxStrategies
  • Jeffrey Wolf, EPL Inc, on behalf of ToxStategies
2:45 pmbreak

3:00 pmScience issue 5: Database for reproductive and developmental effects

Facilitated discussion of science issue with all attendees, including:
  • Max Costa, New York University Medical Center (via telephone)
  • Liz Geltman, City University of New York School of Public Health
  • Deborah Proctor, ToxStrategies, on behalf of Electric Power Research Institute
Science issue 6: Relation between anemia and oral tumors in rats

Facilitated discussion of science issue with all attendees, including:
  • Max Costa, New York University Medical Center (via telephone)
  • Deborah Proctor, ToxStrategies, on behalf of Electric Power Research Institute
  • Mina Suh, ToxStrategies
  • Chad Thompson, ToxStrategies
Open forum on Hexavalent chromium


NOTE: Epidemiologic, toxicokinetic, and mechanistic studies will be discussed at a future IRIS Public Science Meeting after the corresponding preliminary materials have been released.
5:30 pmAdjourn for the day

Thursday, June 26, 2014

9:00 amRegistration

9:30 amInorganic Arsenic

Introduction
  • Reeder Sams, John Cowden, Janice Lee, EPA/IRIS Assessment Managers
Science issue 1: Application of NRC recommendations

Facilitated discussion of science issue with all attendees, including:
  • Barbara Beck, Gradient Corp
  • Nancy Beck, American Chemistry Council (via telephone)
  • Samuel Cohen, University of Nebraska Medical Center
  • Max Costa, New York University Medical Center (via telephone)
  • Jennifer McPartland, Environmental Defense Fund
  • Lorenz Rhomberg, Gradient Corp, on behalf of Arsenic Science Task Force
  • Joyce Tsuji, Exponent Inc, on behalf of Rio Tinto
  • Kimberly Wise, American Chemistry Council
  • Tracey Woodruff, University of California San Francisco (via telephone)
Science issue 2: Risk-of-bias approach

Facilitated discussion of science issue with all attendees, including:
  • Barbara Beck, Gradient Corp
  • Nancy Beck, American Chemistry Council (via telephone)
  • Samuel Cohen, University of Nebraska Medical Center
  • Max Costa, New York University Medical Center (via telephone)
  • Chuck Elkins, Chuck Elkins & Associates
  • Liz Geltman, City University of New York School of Public Health
  • Juleen Lam, Johns Hopkins University
  • Steven Lamm, Consultants in Epidemiology & Occupational Health and Appalachian Research Initiative for Environmental Sciences
  • Jennifer McPartland, Environmental Defense Fund
  • Patrice Sutton, University of California San Francisco (via telephone)
  • Joyce Tsuji, Exponent Inc, on behalf of Rio Tinto
  • Kimberly Wise, American Chemistry Council
  • Tracey Woodruff, University of California San Francisco (via telephone)
12:15 pmLunch break

1:15 pm Science issue 3: Integrating results of epidemiologic studies

Facilitated discussion of science issue with all attendees, including:
  • Barbara Beck, Gradient Corp
  • Nancy Beck, American Chemistry Council (via telephone)
  • Samuel Cohen, University of Nebraska Medical Center
  • Max Costa, New York University Medical Center (via telephone)
  • Juleen Lam, Johns Hopkins University
  • Steven Lamm, Consultants in Epidemiology & Occupational Health and Appalachian Research Initiative for Environmental Sciences
  • Joyce Tsuji, Exponent Inc, on behalf of Rio Tinto
  • Tracey Woodruff, University of California San Francisco (via telephone)
  • Kimberly Wise, American Chemistry Council
2:45 pmbreak

3:00 pmScience issue 4: Concordance of effects between humans and animals

Facilitated discussion of science issue with all attendees, including:
  • Barbara Beck, Gradient Corp
  • Samuel Cohen, University of Nebraska Medical Center
  • Max Costa, New York University Medical Center (via telephone)
  • Steven Lamm, Consultants in Epidemiology & Occupational Health and Appalachian Research Initiative for Environmental Sciences
  • Joyce Tsuji, Exponent Inc, on behalf of Rio Tinto
  • Kimberly Wise, American Chemistry Council
Science issue 5: Upstream biological events for clinical disease endpoints

Facilitated discussion of science issue with all attendees, including:
  • Barbara Beck, Gradient Corp
  • Samuel Cohen, University of Nebraska Medical Center
  • Max Costa, New York University Medical Center (via telephone)
  • Joyce Tsuji, Exponent Inc, on behalf of Rio Tinto
5:00 pmAdjourn for the day

Friday, June 27, 2014



9:30 amInorganic Arsenic (continued)

Science issue 6: Mode-of-action and adverse outcome pathways

Facilitated discussion of science issue with all attendees, including:
  • Barbara Beck, Gradient Corp
  • Nancy Beck, American Chemistry Council (via telephone)
  • Samuel Cohen, University of Nebraska Medical Center
  • Max Costa, New York University Medical Center (via telephone)
  • Robinan Gentry, Environ Corp, on behalf of Electric Power Research Institute
  • Jennifer McPartland, Environmental Defense Fund
  • Kimberly Wise, American Chemistry Council
Science issue 7: In-utero exposure leading to disease later in life

Facilitated discussion of science issue with all attendees, including:
  • Barbara Beck, Gradient Corp
  • Samuel Cohen, University of Nebraska Medical Center
  • Max Costa, New York University Medical Center (via telephone)
  • John DeSesso, Exponent Inc, on behalf of Arsenic Science Task Force
12:00 pmLunch break

1:00 pm Science issue 8 (new): Implications of nutritional factors on internal dose and response

Facilitated discussion of science issue with all attendees, including:
  • Barbara Beck, Gradient Corp
  • Steven Lamm, Consultants in Epidemiology & Occupational Health and Appalachian Research Initiative for Environmental Sciences
Open forum on inorganic arsenic

2:30 pmOpen forum and discussion (may start sooner if previous discussion ends early)

4:30 pmAdjourn

NOTE: Affiliations and sponsors are self-reported.

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