Jump to main content.


Captan (CASRN 133-06-2)

IRIS
List of IRIS Substances




view QuickView

Main Contents

Go

0018

Captan; CASRN 133-06-2

Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and II (Carcinogenicity Assessment for Lifetime Exposure) present the conclusions that were reached during the assessment development process. Supporting information and explanations of the methods used to derive the values given in IRIS are provided in the guidance documents located on the IRIS website.

STATUS OF DATA FOR Captan

File First On-Line 01/31/1987

Category (section)
Status
Last Revised
Oral RfD Assessment (I.A.) on-line 03/01/1989
Inhalation RfC Assessment (I.B.) no data 07/01/1992
Carcinogenicity Assessment (II.) no data

_I.  Chronic Health Hazard Assessments for Noncarcinogenic Effects

_I.A. Reference Dose for Chronic Oral Exposure (RfD)

Substance Name — Captan
CASRN — 133-06-2
Last Revised — 03/01/1989

The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Please refer to the Background Document for an elaboration of these concepts. RfDs can also be derived for the noncarcinogenic health effects of substances that are also carcinogens. Therefore, it is essential to refer to other sources of information concerning the carcinogenicity of this substance. If the U.S. EPA has evaluated this substance for potential human carcinogenicity, a summary of that evaluation will be contained in Section II of this file.

__I.A.1. Oral RfD Summary

Critical Effect
Experimental Doses*
UF
MF
RfD

Decreased mean body
weights

One-Generation and
Three-Generation Rat
Reproduction Studies

Stauffer Chemical
Co., 1982a;
Chevron Chemical
Co., 1982

NOEL: 12.5 mg/kg/day

LEL: 25.0 mg/kg/day
100
1
1.3E-1
mg/kg/day

*Conversion Factors -- Actual dose tested

__I.A.2. Principal and Supporting Studies (Oral RfD)

Stauffer Chemical Company. 1982a. MRID No. 00120315. Chevron Chemical Company. 1982. MRID No. 00125293. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

Male and female COBS CD weanling rats were given captan in the diet at dosage levels of 0, 6, 12.5, and 25 mg/kg/day (Stauffer Chemical Co., 1982a). After 102 days of treatment, 15 males were mated with 30 females for each of the treatment groups. Parents were necropsied after weaning of F1 pups; observations were made for signs of toxicity, changes in general behavior, appearance and survival (in parents and pups); body weights and food consumption (in parents); male and female fertility, length of gestation and litter sizes. No compound related effects were seen at any dosage level.

Captan was administered in the diet at dosage levels of 0, 25, 100, 250, and 500 mg/kg/day to male and female COBS CD rats for three generations (Chevron Chemical Co., 1982). For each generation 15 males were mated with 30 females. Litter parameters recorded were: survival, weight, gross appearance and macroscopic pathology. A teratology examination was performed on 30 F2 females.

No treatment-related effects because of administration of captan in the diet were seen with the exception of body weight reduction and food consumption. A dose-related decreased in both male and female parent body weight was reported at 100, 250, and 500 mg/kg/day. A related decrease in food consumption was reported for all groups except for 25 mg/kg/day in the F1 males and F2 females and 100 mg/kg/day females. Pup survival was reduced at 250 and 500 mg/kg/day. A decrease in pup litter weights was observed in all dosage groups.

__I.A.3. Uncertainty and Modifying Factors (Oral RfD)

UF — An uncertainty factor of 100 was used to account for the inter- and intraspecies differences.

MF — None

__I.A.4. Additional Studies/Comments (Oral RfD)

The new chronic dog study (10/25/1988), although core grade supplementary is sufficient to complete the required data base. The NOEL from the combined reproduction studies remain the most sensitive endpoint.

Data Considered for Establishing the RfD:

1) 1-Generation and 3-Generation Reproduction - rat: Principal study - see previous description;

2) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=2000 ppm (100 mg/kg/day) (HDT); core grade minimum (Makhteshim Chemical Works Ltd., 1983)

3) 1-Year Feeding - dog: NOEL=60 mg/kg/day; LEL=300 mg/kg/day (emesis and soft/mucoid stools); core grade supplementary (ICI Americas, Inc., 1988)

4) Teratology - rabbit: Maternal NOEL=25 mg/kg/day; Maternal LEL=60 mg/kg/day (weight loss); Teratogenic and Fetotoxic NOEL=60 mg/kg/day (HDT); core grade minimum (Chevron Chemical Co., 1981a)

5) Teratology - hamster: Maternal NOEL=50 mg/kg/day; Maternal LEL=200 mg/kg/day (body weight loss, mortality); Fetotoxic NOEL=200 mg/kg/day; Fetotoxic LEL=400 mg/kg/day (HDT; reduced ossification, increased resorptions; decreased body weight); Teratogenic NOEL=400 mg/kg/day (HDT); core grade minimum (Chevron Chemical Co., 1983)

6) Teratology - monkey: Fetotoxic NOEL=12.5 mg/kg/day; Fetotoxic LEL=25 mg/kg/day (HDT; increased mortality); Teratogenic NOEL=25 mg/kg/day (HDT); no core grade (Stauffer Chemical Co., 1968)

Other Data Reviewed:

1) 113-Week Feeding (oncogenic) - mouse: Decreased weight gain and food consumption were observed at all doses [6000, 10000, 16000 ppm (900, 1500, 2400 mg/kg/day)]; core grade guideline (Chevron Chemical Co., 1981b)

2) 2-Year Feeding (oncogenic) - rat: Tentative NOEL=25 mg/kg/day; Tentative LEL=100 mg/kg/day (decreased body weights, hepatocellular hypertrophy, increased weights for kidneys, heart, brain, liver, thyroid, and parathyroid); core grade reserved (Stauffer Chemical Chemical Co., 1982b)

Data Gap(s): None

__I.A.5. Confidence in the Oral RfD

Study — Medium
Database — High
RfD — High

The critical study is of adequate quality and is given a medium confidence rating. Additional studies are supportive and of adequate quality; therefore, the database is given a high confidence rating. High confidence in the RfD follows.

__I.A.6. EPA Documentation and Review of the Oral RfD

Source Document — This assessment is not presented in any existing U.S. EPA document.

Other EPA Documentation — Pesticide Registration Standard, March 1986; Special Review Position Document 2/3, June 1985; Pesticide Registration Files

Agency Work Group Review — 03/25/1986, 01/18/1989

Verification Date — 01/18/1989

__I.A.7. EPA Contacts (Oral RfD)

Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).

Top of page


_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)

Substancel Name -- Captan
CASRN — 133-06-2

Not available at this time.

Top of page


_II.  Carcinogenicity Assessment for Lifetime Exposure

Substance Name — Captan
CASRN — 133-06-2

Not available at this time.

Top of page


_III.  [reserved]
_IV.  [reserved]
_V.  [reserved]


_VI.  Bibliography

Substance Name — Captan
CASRN — 133-06-2
Last Revised — 07/01/1989

_VI.A. Oral RfD References

Chevron Chemical Company. 1981a. MRID No. 00093883. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

Chevron Chemical Company. 1981b. MRID No. 00068076. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

Chevron Chemical Company. 1982. MRID No. 00125293. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

Chevron Chemical Company. 1983. MRID No. 00126348. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

ICI Americas, Inc. 1988. MRID No. 40893604. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

Makhteshim Chemical Works Ltd. 1983. MRID No. 00126529, 00138179. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

Stauffer Chemical Company. 1968. MRID No. 00082274. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

Stauffer Chemical Company. 1982a. MRID No. 00120315. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

Stauffer Chemical Company. 1982b. MRID No. 00120316. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

Top of page


_VI.B. Inhalation RfC References

None

Top of page


_VI.C. Carcinogenicity Assessment References

None

Top of page


_VII.  Revision History

Substance Name — Captan
CASRN — 133-06-2

Date
Section
Description
03/31/1987 IV. Regulatory Action section on-line
06/30/1988 I.A. Principal references clarified
06/30/1988 I.A.2. Text revised
02/01/1989 I.A. Withdrawn; new RfD verified (in preparation)
03/01/1989 I.A. Revised oral RfD summary added
07/01/1989 VI. Bibliography on-line
01/01/1992 IV. Regulatory actions updated
07/01/1992 I.B. Inhalation RfC now under review
08/01/1995 I.B. EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995.
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
01/09/2002 I.A., II. This chemical is being reassessed under the IRIS Program.
02/09/2004 I.A., II. This chemical is no longer being reassessed under the IRIS Program. See Federal Register February 9, 2004 (Volume 69, Number 26).

Top of page


_VIII.  Synonyms

Substance Name — Captan
CASRN — 133-06-2
Last Revised — 01/31/1987

Top of page

Recent Additions | Search IRIS | IRIS Home | NCEA Home | ORD Home


Jump to main content.