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1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) (CASRN 76-13-1)

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1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113); CASRN 76-13-1

Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and II (Carcinogenicity Assessment for Lifetime Exposure) present the conclusions that were reached during the assessment development process. Supporting information and explanations of the methods used to derive the values given in IRIS are provided in the guidance documents located on the IRIS website.

STATUS OF DATA FOR CFC-113

File First On-Line 01/31/1987

Category (section)
Status
Last Revised
Oral RfD Assessment (I.A.) on line 02/01/1996
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data

_I.  Chronic Health Hazard Assessments for Noncarcinogenic Effects

_I.A. Reference Dose for Chronic Oral Exposure (RfD)

Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Last Revised — 02/01/1996

The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Please refer to the Background Document for an elaboration of these concepts. RfDs can also be derived for the noncarcinogenic health effects of substances that are also carcinogens. Therefore, it is essential to refer to other sources of information concerning the carcinogenicity of this substance. If the U.S. EPA has evaluated this substance for potential human carcinogenicity, a summary of that evaluation will be contained in Section II of this file.

NOTE: The Oral RfD for 1,1,2-trichloro-1,2,2-trifluoroethane may change in the near future pending the outcome of a further review now being conducted by the Oral RfD Work Group.

__I.A.1. Oral RfD Summary

Critical Effect
Experimental Doses*
UF
MF
RfD

Psychomotor impairment

Epidemiologic Study:
Human Occupational
Exposure

Imbus and Adkins, 1972

NOAEL: 5358 mg/cu.m
converted to
273 mg/kg/day
10
1
3E+1
mg/kg/day

*Conversion Factors: 10 cu.m/day (8-hour human breathing volume), 5 days/7 days, 0.5 absorption factor, 70 kg bw; thus, 5358 mg/cu.m x 10 cu.m/day x 5 days/7 days x 0.5/70 kg = 273 mg/kg/day

__I.A.2. Principal and Supporting Studies (Oral RfD)

Imbus, H.R. and C. Adkins. 1972. Physical examination of workers exposed to trichlorotrifluoroethane. Arch. Environ. Health. 24(4): 257-261.

Several animal inhalation studies reported negative results in dogs, rabbits, and rats chronically exposed to very high concentrations of trichlorotrifluoroethane (U.S. EPA, 1983). No apparent adverse effects have been reported in humans occupationally exposed to trichlorotrifluoroethane at either 500 mg/cu.m levels for 11 years or 5358 mg/cu.m levels for 2.77 years (Imbus and Adkins, 1972).

Slight impairment of psychomotor performance was reported in male volunteers exposed to trichlorotrifluoroethane concentrations of 19,161 mg/cu.m for 2.75 hours (Stopps and McLaughlin, 1967). This exposure period was too brief to consider a NOAEL for chronic exposure. Therefore, the RfD of 30 mg/kg/day is considered protective.

__I.A.3. Uncertainty and Modifying Factors (Oral RfD)

UF — The uncertainty factor of 10 accounts for the expected interhuman variability to the toxicity of this chemical in lieu of specific data.

MF — None

__I.A.4. Additional Studies/Comments (Oral RfD)

None.

__I.A.5. Confidence in the Oral RfD

Study — Low
Database — Low
RfD — Low

Confidence in the chosen study, database, and RfD are all considered low. Despite the fact that the chosen study describes human data and the fact that several chronic studies in animals are supportive, uncertainties in both the exposure levels and route extrapolation preclude higher confidence ratings.

__I.A.6. EPA Documentation and Review of the Oral RfD

Source Docuemnt -- U.S. EPA, 1983

Other EPA Documentation — None

Agency Work Group Review — 06/24/1985, 07/08/1985

Verification Date — 07/08/1985

Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for 1,1,2-Trichloro-1,2,2-trifluoroethane conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.

__I.A.7. EPA Contacts (Oral RfD)

Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).

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_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)

Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1

Not available at this time.

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_II.  Carcinogenicity Assessment for Lifetime Exposure

Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1

Not available at this time.

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_III.  [reserved]
_IV.  [reserved]
_V.  [reserved]


_VI.  Bibliography

Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Last Revised — 01/01/1990

_VI.A. Oral RfD References

Imbus, H.R. and C. Adkins. 1972. Physical examination of workers exposed to trichlorotrifluoroethane. Arch. Environ. Health. 24(4): 257-261.

Stopps, G.J. and M. McLaughlin. 1967. Psychophysiological testing of human subjects exposed to solvent vapors. Amer. Ind. Hyg. Assoc. J. 28: 43-50.

U.S. EPA. 1983. Health Assessment Document for 1,1,2-trichloro-1,2,2- trifluoroethane (chlorofluorocarbon CFC 113). Office of Air Quality Planning and Standards, Research Triangle Park, NC. EPA-600/8-82-002F. NTIS PB84- 118843. (Final Report)

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_VI.B. Inhalation RfC References

None

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_VI.C. Carcinogenicity Assessment References

None

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_VII.  Revision History

Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1

Date
Section
Description
04/06/1987 I.A.1. RfD corrected
03/01/1988 I.A.1. Dose conversion factor corrected
12/01/1988 I.A. RfD noted as pending change
01/01/1990 I.A.6. Added U.S. EPA citation
01/01/1990 VI. Bibliography on-line
06/01/1990 IV.A.1. Area code for EPA contact corrected
01/01/1992 I.A.7. Primary contact changed
01/01/1992 IV. Regulatory actions updated
04/01/1992 IV.A.1. CAA regulatory action withdrawn
08/01/1995 I.A. EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995.
02/01/1996 I.A.7. Contact changed
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
12/03/2002 I.A.6. Screening-Level Literature Review Findings message has been added.

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_VIII.  Synonyms

Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Last Revised — 01/31/1987

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