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Nitrapyrin (CASRN 1929-82-4)

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0176

Nitrapyrin; CASRN 1929-82-4

Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and II (Carcinogenicity Assessment for Lifetime Exposure) present the conclusions that were reached during the assessment development process. Supporting information and explanations of the methods used to derive the values given in IRIS are provided in the guidance documents located on the IRIS website.

STATUS OF DATA FOR Nitrapyrin

File First On-Line 03/31/1987

Category (section)
Status
Last Revised
Oral RfD Assessment (I.A.) withdrawn 03/01/1996
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data

_I.  Chronic Health Hazard Assessments for Noncarcinogenic Effects

_I.A. Reference Dose for Chronic Oral Exposure (RfD)

Substance Name — Nitrapyrin
CASRN — 1929-82-4

The Oral RfD for nitrapyrin has been withdrawn on 07/01/1992 as a result of further review. A new RfD summary is in preparation by the RfD/RfC Work Group.

Agency Work Group Review — 09/29/1986, 05/27/1991

EPA Contacts:

Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).

Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for nitrapyrin conducted in August 2003 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or 202-566-1676.

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_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)

Substance Name — Nitrapyrin
CASRN — 1929-82-4

Not available at this time.

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_II.  Carcinogenicity Assessment for Lifetime Exposure

Substance Name — Nitrapyrin
CASRN — 1929-82-4

This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.

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_III.  [reserved]
_IV.  [reserved]
_V.  [reserved]


_VI.  Bibliography

Substance Name — Nitrapyrin
CASRN — 1929-82-4

Not available at this time.

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_VII.  Revision History

Substance Name — Nitrapyrin
CASRN — 1929-82-4

Date
Section
Description
03/01/1991 I.A.4. Citations added
03/01/1991 VI. Bibliography on-line
01/01/1992 IV. Regulatory actions updated
07/01/1992 I.A. Withdrawn; new RfD verified (in preparation)
07/01/1992 VI.A. Oral RfD references withdrawn
08/01/1995 I.A., VI.A. EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995.
03/01/1996 I.A. Contact changed
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
10/28/2003 I.A Screening-Level Literature Review Findings message has been added.

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_VIII.  Synonyms

Substance Name — Nitrapyrin
CASRN — 1929-82-4
Last Revised — 03/31/1987

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