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Dimethylamine (CASRN 124-40-3)

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0228

Dimethylamine; CASRN 124-40-3

Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and II (Carcinogenicity Assessment for Lifetime Exposure) present the conclusions that were reached during the assessment development process. Supporting information and explanations of the methods used to derive the values given in IRIS are provided in the guidance documents located on the IRIS website.

STATUS OF DATA FOR Dimethylamine

File First On-Line 07/01/1990

Category (section)
Status
Last Revised
Oral RfD Assessment (I.A.) no data 07/01/1990
Inhalation RfC Assessment (I.B.) withdrawn 01/01/1991
Carcinogenicity Assessment (II.) no data

_I.  Chronic Health Hazard Assessments for Noncarcinogenic Effects

_I.A. Reference Dose for Chronic Oral Exposure (RfD)

Substance Name — Dimethylamine
CASRN — 124-40-3

Not available at this time.


_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)

Substance Name — Dimethylamine
CASRN — 124-40-3

The inhalation RfC for this substance has been withdrawn as a result of further review. A new RfC summary is in preparation by the RfD/RfC Work Group.

Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfC for Dimethylamine conducted in November 2001 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.

EPA Contacts:

Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).

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_II.  Carcinogenicity Assessment for Lifetime Exposure

Substance Name — Dimethylamine
CASRN — 124-40-3

Not available at this time.

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_III.  [reserved]
_IV.  [reserved]
_V.  [reserved]


_VI.  Bibliography

Substance Name — Dimethylamine
CASRN — 124-40-3

Not available at this time.

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_VII.  Revision History

Substance Name — Dimethylamine
CASRN — 124-40-3

Date
Section
Description
07/01/1990 I.B. Inhalation RfC summary on-line
07/01/1990 VI. Bibliography on-line
01/01/1991 I.B. Withdrawn; new Inhalation RfC verified (in preparation)
01/01/1991 VI. Bibliography withdrawn
01/01/1992 IV. Regulatory Action section on-line
08/01/1995 I.B., VI. EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995.
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
12/03/2002 I.B. Screening-Level Literature Review Findings message has been added.

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_VIII.  Synonyms

Substance Name — Dimethylamine
CASRN — 124-40-3
Last Revised — 07/01/1990

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