Jump to main content.


Molinate (CASRN 2212-67-1)

IRIS
List of IRIS Substances




view QuickView

Main Contents

Go

0298

Molinate; CASRN 2212-67-1

Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and II (Carcinogenicity Assessment for Lifetime Exposure) present the conclusions that were reached during the assessment development process. Supporting information and explanations of the methods used to derive the values given in IRIS are provided in the guidance documents located on the IRIS website.

STATUS OF DATA FOR Molinate

File First On-Line 09/26/1988

Category (section)
Status
Last Revised
Oral RfD Assessment (I.A.) on-line 02/01/1991
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data

_I.  Chronic Health Hazard Assessments for Noncarcinogenic Effects

_I.A. Reference Dose for Chronic Oral Exposure (RfD)

Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
Last Revised — 02/01/1991

The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Please refer to the Background Document for an elaboration of these concepts. RfDs can also be derived for the noncarcinogenic health effects of substances that are also carcinogens. Therefore, it is essential to refer to other sources of information concerning the carcinogenicity of this substance. If the U.S. EPA has evaluated this substance for potential human carcinogenicity, a summary of that evaluation will be contained in Section II of this file.

__I.A.1. Oral RfD Summary

Critical Effect
Experimental Doses*
UF
MF
RfD

Reproductive toxicity

Rat Fertility Study
(gavage)

Stauffer Chemical Co.,
1981

NOEL: 0.2 mg/kg/day

LEL: 4 mg/kg/day

100
1
2E-3
mg/kg/day

*Conversion Factors -- 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)

__I.A.2. Principal and Supporting Studies (Oral RfD)

Stauffer Chemical Company. 1981. MRID No. 00079209. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

Six groups of male Sprague-Dawley rats were administered technical grade molinate by corn oil gavage at 0, 0.2, 4, 12, 30, and 60 mg/kg/day. Samples were taken from each dose solution for concentration analysis and archival retention. There were no significant reductions in male or female fertility indices at 0.2 mg/kg/day, but there were considerable reductions including dose-related alterations in sperm morphology in both male and female indices at 4 mg/kg/day. The necropsy data for pregnant females indicated a significant reduction in the number of viable fetuses/litter as a result of matings in the 4 mg/kg/day group. An increase in the number of resorptions/ litter as a result of matings of untreated females with males in the 4 mg/kg/day dose group was also observed. Based on the above effects, the NOEL and LEL are 0.2 and 4 mg/kg/day, respectively.

__I.A.3. Uncertainty and Modifying Factors (Oral RfD)

UF — An uncertainty factor of 100 was used to account for the inter- and intraspecies differences. An additional UF was not used to account for the lack of a long-term dog study since the 13-week studies showed that the dog is not likely to be more sensitive than the rat.

MF — None

__I.A.4. Additional Studies/Comments (Oral RfD)

Data Considered for Establishing the RfD:

  1. Fertility - rat: Principal study - see previous description; core grade supplementary
  2. 3-Generation Reproduction - rat: NOEL=0.63 mg/kg/day (HDT); core grade minimum (Stauffer Chemical Co., 1977a)
  3. 2-Year Feeding (oncogenic) - rat: Systemic NOEL=0.63 mg/kg/day; Systemic LEL=2 mg/kg/day (increase in organ weight); core grade minimum (Stauffer Chemical Co., 1977b)
  4. 13-Week Feeding - dog: NOEL=22.5 mg/kg/day; LEL=45 mg/gk/day (increased thyroid weight); no core grade (Stauffer Chemical Co., 1964a)
  5. 13-Week Feeding - rat: NOEL=8 mg/kg/day; LEL=16 mg/kg/day (ovarian vacuolation); no core grade (Stauffer Chemical Co., 1964b)

Data Gap(s): Chronic Dog Feeding Study, Rat Teratology Study, Rabbit Teratology Study

__I.A.5. Confidence in the Oral RfD

Study — Medium
Database — Low
RfD — Low

The critical study is of fair quality and is given a medium confidence rating. Since the database on chronic toxicity is poor, the database is given a low confidence rating. Low confidence in the RfD follows.

__I.A.6. EPA Documentation and Review of the Oral RfD

Source Document — This assessment is not presented in any existing U.S. EPA document.

Other EPA Documentation — Pesticide Registration Files

Agency Work Group Review — 09/16/1986, 04/15/1987, 03/23/1988

Verification Date — 03/23/1988

Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Molinate conducted in November 2001 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.

__I.A.7. EPA Contacts (Oral RfD)

Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).

Top of page


_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)

Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram

Not available at this time.

Top of page


_II.  Carcinogenicity Assessment for Lifetime Exposure

Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram

This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.

Top of page


_III.  [reserved]
_IV.  [reserved]
_V.  [reserved]


_VI.  Bibliography

Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
Last Revised — 02/01/1991

_VI.A. Oral RfD References

Stauffer Chemical Company. 1964a. MRID No. 00092283. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

Stauffer Chemical Company. 1964b. MRID No. 00092282. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

Stauffer Chemical Company. 1977a. MRID No. 00054571. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

Stauffer Chemical Company. 1977b. MRID No. 00054570. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

Stauffer Chemical Company. 1981. MRID No. 00079209. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

Top of page


_VI.B. Inhalation RfC References

None

Top of page


_VI.C. Carcinogenicity Assessment References

None

Top of page


_VII.  Revision History

Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram

Date
Section
Description
09/26/1988 I.A. Oral RfD summary on-line
02/01/1991 I.A. Text edited
02/01/1991 VI. Bibliography on-line
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
12/03/2002 I.A.6. Screening-Level Literature Review Findings message has been added.

Top of page


_VIII.  Synonyms

Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
Last Revised — 09/26/1988

Top of page

Recent Additions | Search IRIS | IRIS Home | NCEA Home | ORD Home


Jump to main content.