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p-Nitrophenol (CASRN 100-02-7)

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0484

p-Nitrophenol; CASRN 100-02-7

Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and II (Carcinogenicity Assessment for Lifetime Exposure) present the conclusions that were reached during the assessment development process. Supporting information and explanations of the methods used to derive the values given in IRIS are provided in the guidance documents located on the IRIS website.

STATUS OF DATA FOR p-Nitrophenol

File First On-Line 10/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment (I.A.) no data
Inhalation RfC Assessment (I.B.) message 10/01/1991
Carcinogenicity Assessment (II.) no data

_I.  Chronic Health Hazard Assessments for Noncarcinogenic Effects

_I.A. Reference Dose for Chronic Oral Exposure (RfD)

Substance Name — p-Nitrophenol
CASRN — 100-02-7

Not available at this time.

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_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)

Substance Name — p-Nitrophenol
CASRN — 100-02-7

The health effects data for 4-nitrophenol were reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for the derivation of an inhalation RfC. The verification status for this chemical is currently not verifiable. For additional informationon health effects of this chemical, interested parties are referred to the documentation listed below.

U.S. EPA. 1980. Ambient Water Quality Criteria Document for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Criteria and Standards Division, Washington, DC. October. EPA 440/5-80-063.

U.S. EPA. 1985. Health and Environmental Effects Profile for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

U.S. EPA. 1987. Health Effects Assessment for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteia and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

Agency Work Group Review — 06/13/1991

Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfC for p-Nitrophenol conducted in November 2001 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.

EPA Contacts:

Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).

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_II.  Carcinogenicity Assessment for Lifetime Exposure

Substance Name — p-Nitrophenol
CASRN — 100-02-7

Not available at this time.

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_III.  [reserved]
_IV.  [reserved]
_V.  [reserved]


_VI.  Bibliography

Substance Name — p-Nitrophenol
CASRN — 100-02-7
Last Revised — 10/01/1991

_VI.A. Oral RfD References

None

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_VI.B. Inhalation RfC References

U.S. EPA. 1980. Ambient Water Quality Criteria Document for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Criteria and Standards Division, Washington, DC. October. EPA 440/5-80-063.

U.S. EPA. 1985. Health and Environmental Effects Profile for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

U.S. EPA. 1987. Health Effects Assessment for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteia and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

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_VI.C. Carcinogenicity Assessment References

None

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_VII.  Revision History

Substance Name — p-Nitrophenol
CASRN — 100-02-7

Date
Section
Description
08/01/1991 I.A. Oral RfD now under review
08/01/1991 I.B. Inhalation RfC now under review
10/01/1991 I.B. Inhalation RfC message on-line
10/01/1991 VI. Bibliography on-line
08/01/1995 I.A EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995.
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
12/03/2002 I.B. Screening-Level Literature Review Findings message has been added.

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_VIII.  Synonyms

Substance Name — p-Nitrophenol
CASRN — 100-02-7
Last Revised — 10/01/1991

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