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Methyl isocyanate (CASRN 624-83-9)

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0527

Methyl isocyanate; CASRN 624-83-9

Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and II (Carcinogenicity Assessment for Lifetime Exposure) present the conclusions that were reached during the assessment development process. Supporting information and explanations of the methods used to derive the values given in IRIS are provided in the guidance documents located on the IRIS website.

STATUS OF DATA FOR Methyl isocyanate

File First On-Line 03/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment (I.A.) no data  
Inhalation RfC Assessment (I.B.) message 03/01/1991
Carcinogenicity Assessment (II.) no data  

_I.  Chronic Health Hazard Assessments for Noncarcinogenic Effects

_I.A. Reference Dose for Chronic Oral Exposure (RfD)

Substance Name — Methyl isocyanate
CASRN — 624-83-9

Not available at this time.

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_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)

Substance Name — Methyl isocyanate
CASRN — 624-83-9

The health effects data for methyl isocyanate have been reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for derivation of an inhalation RfC. The verification status of this chemical is currently not verifiable. For additional information on the health effects of this chemical, interested parties are referred to the EPA documentation listed below.

U.S. EPA. 1987. Health Asssessment Document for Methyl Isocyanate. Workshop Draft. Prepared by the Environmental Criteria and Assessment Office, Research Triangle Park, NC.

Agency Work Group Review — 12/18/1990

Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfC for Methyl isocyanate conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.

EPA Contacts:

Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).

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_II.  Carcinogenicity Assessment for Lifetime Exposure

Substance Name — Methyl isocyanate
CASRN — 624-83-9

This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.

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_III.  [reserved]
_IV.  [reserved]
_V.  [reserved]


_VI.  Bibliography

Substance Name — Methyl isocyanate
CASRN — 624-83-9
Last Revised — 03/01/1991

_VI.A. Oral RfD References

None

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_VI.B. Inhalation RfC References

U.S. EPA. 1987. Health Asssessment Document for Methyl Isocyanate. Workshop Draft. Prepared by the Environmental Criteria and Assessment Office, Research Triangle Park, NC.

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_VI.C. Carcinogenicity Assessment References

None

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_VII.  Revision History

Substance Name — Methyl isocyanate
CASRN — 624-83-9

Date
Section
Description
03/01/1991 I.B. Inhalation RfC message on-line
03/01/1991 VI. Bibliography on-line
01/01/1992 IV. Regulatory Action section on-line
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
12/03/2002 I.B. Screening-Level Literature Review Findings message has been added.

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_VIII.  Synonyms

Substance Name — Methyl isocyanate
CASRN — 624-83-9
Last Revised — 03/01/1991

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