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Diethyl sulfate (CASRN 64-67-5)

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0615

Diethyl sulfate; CASRN 64-67-5

Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and II (Carcinogenicity Assessment for Lifetime Exposure) present the conclusions that were reached during the assessment development process. Supporting information and explanations of the methods used to derive the values given in IRIS are provided in the guidance documents located on the IRIS website.

STATUS OF DATA FOR Diethyl sulfate

File First On-Line 11/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment (I.A.) no data  
Inhalation RfC Assessment (I.B.) message 11/01/1991
Carcinogenicity Assessment (II.) no data  

_I.  Chronic Health Hazard Assessments for Noncarcinogenic Effects

_I.A. Reference Dose for Chronic Oral Exposure (RfD)

Substance Name — Diethyl sulfate
CASRN — 64-67-5

Not available at this time.

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_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)

Substance Name — Diethyl sulfate
CASRN — 64-67-5

The health effects data for diethyl sulfate were reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for derivation of an inhalation RfC. The verification status of this chemical is currently not verifiable. For additional information on the health effects of this chemical, interested parties are referred to the EPA documentation listed below.

U.S. EPA. 1989. Reportable Quantity Document for Diethyl Sulfate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response.

Agency Work Group Review — 09/12/1991

EPA Contacts:

Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).

Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfC for Diethyl sulfate conducted in August 2003 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or 202-566-1676.

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_II.  Carcinogenicity Assessment for Lifetime Exposure

Substance Name — Diethyl sulfate
CASRN — 64-67-5

This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.

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_III.  [reserved]
_IV.  [reserved]
_V.  [reserved]


_VI.  Bibliography

Substance Name — Diethyl sulfate
CASRN — 64-67-5
Last Revised — 11/01/1991

_VI.A. Oral RfD References

None

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_VI.B. Inhalation RfC References

U.S. EPA. 1989. Reportable Quantity Document for Diethyl Sulfate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response.

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_VI.C. Carcinogenicity Assessment References

None

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_VII.  Revision History

Substance Name — Diethyl sulfate
CASRN — 64-67-5

Date
Section
Description
10/01/1991 I.B. Inhalation RfC now under review
11/01/1991 I.B. Inhalation RfC message on-line
11/01/1991 VI.B. Inhalation RfC references added
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
10/28/2003 I.B. Screening-Level Literature Review Findings message has been added.

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_VIII.  Synonyms

Substance Name — Diethyl sulfate
CASRN — 64-67-5
Last Revised — 11/01/1991

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