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MED respirable elongated particle dose-response research

Description/Rationale and Research Approach:

Fine particle research in the 1980s at MED developed a large database of toxicologically relevant exposure dose characterizations (TEM, surface area, XRD, EDS, etc.) for determination of in vivo dose changes and consequent relative potencies of microscopic elongated particles (EPs). While these data were useful for aquatic bioavailability investigations, they were also very applicable to determination of relative potencies of complex inhaled EP mixtures for asbestos-related diseases in humans. Support for the recent EPA need to acquire toxicological data for evaluation of health risks associated with amphibole EPs in Libby, MT, is the basis for present MED research on optimizing models for prediction of EP in vivo dose changes and relative potencies (especially for mesothelioma). Modern computing techniques and statistical models make the present data analyses far more powerful and applicable than 1980s technologies would allow.

MED Scientists:

Dale Hoff

Publications:

Duncan, K.E., P.M. Cook, S.H. Gavett, L.A. Dailey, R.K. Mahoney, A.J. Ghio, V.L. Roggi, and R.B. Devlin. 2014. In vitro determinents of asbestos fiber toxicity: Effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells. Particle and Fibre Toxicity 11:1-14.

Aust, A.E., P.M. Cook, and R.F. Dodson. 2011. Morphological and chemical mechanisms of elongated mineral particle toxicities. Journal of Toxicology and Environmental Health, Part B: Critical Reviews 14:40-75.

Expected Products:

Date

Product

Contact

4th quarter 2013

Analyses of pleural dose-response data to better understand relative potency of Libby Amphibole for mesothelioma in comparison to other elongated particle exposures.

Dale Hoff

4th quarter 2013

Lung tumor dose-response and particokinetic relationships with application to Libby Amphibole.

Dale Hoff

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