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In-use tools are supported and upgraded

Description:

ORD has developed large data repositories that are currently in use across EPA and in the public sector, specifically the ECOTOX, ExpoCastDB, MetaPath, ToxRefDB, ToxCastDB, and ACToR databases. These tools have a diverse client-base and support a wide range of Agency regulatory requirements (e.g., CWA, FIFRA, CERCLA, RCRA). This task will focus on continued maintenance of existing non-CBI data collections and software, and systematic updates of databases to include newly released data that meet QA/QC requirements. These data collections will be critical components of the dashboard workbench to be developed under 7.2, and to this end, the task includes preparation of these applications for seamless integration into the final dashboards.

Rationale and Research Approach:

1. Continued Maintenance of Data Collections: The tools include in this task cover human health and environmental endpoints, measured in environmental media, whole organisms, or in vitro assays. Through the continuous identification, collection, data abstraction, and release of data via publicly accessible websites, the ORD tools will provide a ready source of information on a wide range of chemicals and species for use in risk assessment and in a variety of research activities. Data stewards will have discussions with the Program Offices to identify priorities (e.g., chemicals, species, endpoints, etc.) for new data to be included in scheduled updates.

2. Continued Maintenance of Application Infrastructure: In order to maintain the accessibility, security, and integrity of each data collection, applications must adhere to Agency IT policies related to application development and web protocols and procedures.

3. Readying Applications for Inclusion in Dashboards: As critical components of the dashboard workbench, to be developed under Project 7.2, each data steward will be responsible for assisting in preparing their data collection for use within the CSS dashboards. This process will include identifying when data are ready for release to clients, and possible restrictions to data included in the dashboards (e.g., quality of test design). Data stewards will work with collaborators under 7.2 to ensure systematic updates of data following EPA policies and procedures as outlined by the Office of Environmental Information, maintaining the accessibility, security, and integrity of the data. This will be especially important if the data are not linked directly to the original data collection from the dashboard. Discussions with the Program Offices will be undertaken to ensure a clear understanding of objectives related to the data need exist.

4. Develop Cross-Linkages between Databases: As large amounts of data are generated via high throughput (HTS) testing techniques (e.g., ToxCast), comprehensive and high quality in vivo databases will be needed in order to ground truth the in vitro test results. Currently signatures of chemical toxicity linking mammalian in vivo test data (e.g., ToxRefDB) to ToxCast HTS results have been developed, but there is a need to expand these types of approaches to include ecologically relevant test species (i.e., ECOTOX). Therefore, building linkages across the various databases will be an important component of this task.

MED Scientists:

Patricia Schmieder
Richard Kolanczyk

Publications:

Kolanczyk, R.C., P. Schmieder, W.J. Jones, O.G. Mekenyan , A. Chapkanov, S. Temelkov, S. Kotov, M. Velikova, V. Kamenska, K. Vasilev, M. Manibusan, C. Olinger, R. Kent, P. Shah, A. Khasawinah, and G.D. Veith. 2012. MetaPath: An electronic knowledge base for collating, exchanging and analyzing case studies of xenobiotic metabolism. Regulatory Toxicology and Pharmacology 63:84-96.

Expected Products:

Date

Product

Contact

Sep 30, 2016 Continued maintenance, upgrades and inclusion of in-use tools for human and ecological health effects (e.g., MetaPath, ECOTOX). Christine Russom
Sep 30, 2016 Continued maintenance, upgrade and inclusion of in-use tools and databases for screening and prioritization applications (ToxRefDB, ACToR, ToxCastDB, ExpoCastDB). Christine Russom
Sep 30, 2016 ToxRefDB, ACToR, ToxCastDB and ExpoCastDB integrated in Knowledge Management infrastructure Christine Russom

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