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People in the U.S. are mainly exposed to methylmercury, an organic compound, when they eat fish and shellfish that contain methylmercury. Whether an exposure to the various forms of mercury will harm a person's health depends on a number of factors (below). Almost all people have at least trace amounts of methylmercury in their tissues, reflecting methylmercury’s widespread presence in the environment and people’s exposure through the consumption of fish and shellfish. People may be exposed to mercury in any of its forms under different circumstances. The factors that determine how severe the health effects are from mercury exposure include these:

Mercury exists in three chemical forms. They each have specific effects on human health.

Methylmercury effects

For fetuses, infants, and children, the primary health effect of methylmercury is impaired neurological development. Methylmercury exposure in the womb, which can result from a mother's consumption of fish and shellfish that contain methylmercury, can adversely affect a baby's growing brain and nervous system. Impacts on cognitive thinking, memory, attention, language, and fine motor and visual spatial skills have been seen in children exposed to methylmercury in the womb. Recent human biological monitoring by the Centers for Disease Control and Prevention in 1999 and 2000 (PDF) (3 pp., 42 KB, About PDF) shows that most people have blood mercury levels below a level associated with possible health effects. More recent data from the CDC support this general finding.

Outbreaks of methylmercury poisonings have made it clear that adults, children, and developing fetuses are at risk from ingestion exposure to methylmercury. During these poisoning outbreaks some mothers with no symptoms of nervous system damage gave birth to infants with severe disabilities, it became clear that the developing nervous system of the fetus may be more vulnerable to methylmercury than is the adult nervous system.

For more information on fish consumption advisories across the country, visit EPA's fish consumption web pages.

In addition to the subtle impairments noted above, symptoms of methylmercury poisoning may include; impairment of the peripheral vision; disturbances in sensations ("pins and needles" feelings, usually in the hands, feet, and around the mouth); lack of coordination of movements; impairment of speech, hearing, walking; and muscle weakness. People concerned about their exposure to methylmercury should consult their physician.

Mercury and Cancer. No human data indicate that exposure to any form of mercury causes cancer, but the human data currently available are very limited. Mercuric chloride has caused increases in several types of tumors in rats and mice, and methylmercury has caused kidney tumors in male mice. Scientists only observed these health effects at extremely high doses, above levels that produced other effects. When EPA revised its Cancer Guidelines in 2005, the Agency concluded that neither inorganic mercury nor methylmercury from environmental exposures are likely to cause cancer in humans. More technical information is available in volume V of the 1997 Mercury Study Report to Congress (PDF) (349 pp., 1.2 MB, about PDF) (see especially pages 47, 80, 107, and 161 of the file).

Additional Information:

Additional information on the health effects of methylmercury is available from the IRIS database at http://www.epa.gov/iris/subst/0073.htm and EPA’s Methylmercury Water Quality Criterion Web site at http://www.epa.gov/waterscience/criteria/methylmercury/index.html. You can also visit the Agency for Toxic Substances and Disease Registry (ATSDR) toxicological profile for mercury.

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Elemental mercury effects

Elemental (metallic) mercury primarily causes health effects when it is breathed as a vapor where it can be absorbed through the lungs. These exposures can occur when elemental mercury is spilled or products that contain elemental mercury break and expose mercury to the air, particularly in warm or poorly-ventilated indoor spaces. The first paragraph on this page lists the factors that determine the severity of the health effects from exposure to mercury. Symptoms include these: tremors; emotional changes (e.g., mood swings, irritability, nervousness, excessive shyness); insomnia; neuromuscular changes (such as weakness, muscle atrophy, twitching); headaches; disturbances in sensations; changes in nerve responses; performance deficits on tests of cognitive function. At higher exposures there may be kidney effects, respiratory failure and death. People concerned about their exposure to elemental mercury should consult their physician.

Additional Information:

Additional information on the health effects of elemental mercury is available from the IRIS database at http://www.epa.gov/iris/subst/0370.htm.

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Effects of other mercury compounds (inorganic and organic)

High exposures to inorganic mercury may result in damage to the gastrointestinal tract, the nervous system, and the kidneys. Both inorganic and organic mercury compounds are absorbed through the gastrointestinal tract and affect other systems via this route. However, organic mercury compounds are more readily absorbed via ingestion than inorganic mercury compounds.

Symptoms of high exposures to inorganic mercury include: skin rashes and dermatitis; mood swings; memory loss; mental disturbances; and muscle weakness. People concerned about their exposure to inorganic mercury should consult their physician.

Additional Information:

Information on the health effects of mercuric chloride, an inorganic mercury compound, is available from the IRIS database at http://www.epa.gov/iris/subst/0692.htm. You can also visit the Agency for Toxic Substances and Disease Registry (ATSDR) toxicological profile for mercury.

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