ExpoCast™

Day 1 - Monday, September 26, 2011 (9:45 a.m. – 5:15 p.m.)

Session 1:  Lessons Learned from the Prioritization Model Challenge (90 mins)
Vallero, chair

Brief History of the Challenge and Summary of Results from the April 2010 Meeting – Peter Egeghy

Exposure Based Prioritization Model Challenge Results – Panel (Contractors) (0.75 hours)

The results from each individual model will be presented. Three slides each: (1) Approach; (2) Results; (3) Recommendations.

1. Jon Arnot - RAIDAR/FHX
2. Olivier Jolliet - USEtox
3. Muhilan Pandian - GExFRAME
4. Panos Georgopolous - MENTOR/PROTEGE
5. Luther Smith - SHEDS
6. Cathy Fehrenbacher/Pat Wood - EFAST2

Discussion (15 min)

of Challenge Results (NERL)

1. Meta analysis – Jade Mitchell-Blackwood
2. Gap Analysis: identify key issues – Daniel Vallero
3. Discussion: Compare and contrast the Challenge approaches, highlight areas of concordance

Session 2a: High-throughput Exposure Assessment (75 min)
Cohen Hubal, chair

Results of Tier 1 Exposure-based Prioritization for chemicals - John Wambaugh

Discussion

Session 2b: High-throughput Exposure Assessment Discussion

Break

Session 3: EPA Exposure-Based Approach - Addressing Key Gaps/Issues (3 hours)
Egeghy, chair

2:15 – 5:15

Panel Sessions (30 minutes each)

1. Near Field/Consumer Use (lead: John Cherrie, Hyeong-Moo Shin)
   1. Exposure surrogates (function, sources/emissions, habits/practices)
   2. Utility of scenario approach for rapid prioritization of 1000s chemicals
2. Minimal dataset (lead: Rocky Goldsmith, Bette Meek)
   1. Properties (data needs for QSAR)
   2. Indoor fate
3. Characterizing Uncertainty (lead: Sastry Isukapalli/Gerhard Heinemeyer)
   1. Interpretation of data-poor prioritization (criteria for tiering)
   2. Extrapolating data rich to data poor (building strength)
4. Model Evaluation (lead: Halûk Ozkaynak, Olivier Jolliet)
   1. Benchmarking (common metrics)
   2. Ground-truthing (data sources, partners)
5. Linkages to HTRA (lead: Jon Arnot, John Wambaugh)

Discussion

Adjourn Day 1

Dinner (Serena, 5311 South Miami Blvd., Durham, NC)

Day 2 - Tuesday, September 27, 2011 (8:30 am – 2:30 pm including working lunch)

Session 3: EPA Exposure-Based Approach - Addressing Key Gaps/Issues (2 hours)
Egeghy, chair

Review Discussion Points from Day 1

Break

Session 4: Development of Integrated Decision Support Tools (2 hours)
Mitchell-Blackwood, chair

Integrated Approach Using Decision Analytic Tools [e.g. Multi-Criteria Decision Analysis (MCDA)] - “Using Value of Information to Prioritize Data Needs” (Igor Linkov)

Plans for expert elicitation following workshop: “Integrating Disparate Types of Exposure Information within a Multi-Criteria Decision Framework”

Session 5: Related Initiatives (3 hours)
Vallero, chair

1. Exposure indices for ToxPi (Gangwal)
2. LRI and Cefic Grantees
   1. Shin
   2. Jolliet
   3. Arnot
3. SVOC in the Indoor Environment (Cohen Hubal)
4. TRA: Potential for rapid application to 100s-1000s of chemicals (Debbie Lander)
5. SPIN database update (Stellan Fischer)
6. Food consumption scenario (Gerhard Heinemeyer)
7. Health Canada – Chemical triage (Leona MacKinnon/Heather Patterson)
8. State prioritization approaches (Corey Yep)
9. Harnessing technology for collection of consumer use data (Goldsmith)