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2013 Society of Toxicology Posters and Presentations

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Event Title Author(s) Institute(s)
Poster Development of Medium-Throughput Thyroperoxidase Inhibition Assays for Screening. K. B. Paul1,2, J. M. Hedge2, K. M. Crofton2, M. W. Hornung3, and S. O. Simmons2. 1ORISE, US EPA, RTP, NC; 2Integrated Systems Toxicology Division, NHEERL, ORD, US EPA, RTP, NC; 3Mid-Continent Ecology Division, NHEERL, ORD, US EPA, Duluth, MN.
Poster Use of Novel Assays to Screen Large Chemical Inventories for Functional Estrogen Receptor (ER) Activity. K. Houck1, M. Martin1, R. Judson1, D. Rotroff1, J. Melnick2, J. Lamedin2, and J. Weswick2. 1NCCT, US EPA, RTP, NC; 2Odyssey Thera, San Ramon, CA.
Poster Structural Classification of 1848 Chemicals Evaluated for Estrogenic Activity in 13 HTS Assays. R. Judson1, D. Rotroff1, M. Martin1, D. Reif1, K. Houck1, P. Kothia1, N. Sipes1, T. Knudsen1, M. Xia2, and R. Huang2. 1US EPA, RTP, NC; 2NCGC, Rockville, MD.
Poster Multiplexed gene expression data: cell stress induced promiscuity. D. L. Filer, A.Wilson, M. Martin, K. Houck, and D. Reif, R. Judson. NCCT
Poster A Systematic Analysis of ToxCast In Vitro Assays Associated with In Vivo Hepatic Outcomes. J. Liu1,2, M. T. Martin1, C. Corton3, C. Wood3, and I. Shah1. 1NCCT/US EPA, Durham, NC; 2Univ Arkansas, Little Rock, AR; 3NHERL/US EPA, Durham, NC
Poster Virtual Liver: Mapping Pathways to Liver Injury by Linking In Vitro Assays to In Vivo Outcomes. I. Shah1, J. Liu1, C. Corton2, S. Hester2, K. Houck1, T. Knudsen1, H. el-Masri2, J. E. Simmons2, J. Wambaugh1, and C. Wood2. 1NCCT, US EPA, Durham, NC; 2NHEERL, US EPA, Durham, NC.
Poster Quantitative Dose-Response in a Virtual Hepatic Lobule. J. F. Wambaugh1, J. Jack1, J. Liu1, H.el-Masri2, J. Davis1, W. Setzer1, and I. Shah1. 1NCCT, US EPA, RTP, NC; 2National Health and Environmental Effects Research Laboratory, US EPA, RTP, NC.
Poster Evaluation of the Neuroactivity of ToxCast Compounds Using Multiwell Microelectrode Array Recordings of Primary Cortical Neurons. P. Valdivia1,2, M. Martin3, W. LaFew4, J. Ross2, K. Houck3, and T. J. Shafer4. 1Duke University, Durham, NC; 2Axion Biosystems, Atlanta, GA; 3NCCT, ORD, US EPA, RTP, NC; 4ISTD, ORD, US EPA, RTP, NC.
Poster Validation of a ToxCast Predictive Signature for Vascular Disruption in a Complex Angiogenesis Assay. N. Kleinstreuer1, R. Sarkanen2, T. Heinonen2, and T. Knudsen1. 1NCCT, US EPA, RTP, NC; 2FICAM, Tampere, Finland.
Poster Investigation of a Redox-Sensitive Predictive Model of Mouse Embryonic Stem Cell Differentiation via Quantitative Nuclease Protection Assays and Glutathione Redox Status. K. J. Chandler1, J. M. Hansen2, E. S. Hunter1, and T. Knudsen1. 1NHEERL/NCCT, US EPA, RTP, NC; 2Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Platform Talk Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing. B. A. Wetmore1, J. F. Wambaugh2, H. J. Clewell1, and R. S. Thomas1. 1The Hamner Institutes for Health Sciences, RTP, NC; 2NCCT, US EPA, RTP, NC.
Satellite Meeting Updates on 21st Century Toxicology Activities and Related Efforts: Invited Presentations and Open Microphone
  • ToxCast Update. David Dix, US Environmental Protection Agency.
  • Validation of High-Throughput Assays. Richard Judson, US Environmental Protection Agency.
D. Dix. NCCT, US EPA, RTP. NC
Late Breaking Abstract Interactive Web Application (Dashboard) for ToxCast Data Exploration C. L. Strope, S. Watford, D. Reif, A. Frame, R. Judson, N. Baker, I. Shah, and M. Martin. INSTITUTIONS (ALL): NCCT, US EPA, Research Triangle Park, NC.
Poster Profiling the Activity of Environmental Chemicals in Causing Testicular Dysgenesis Syndrome Using the US EPA Toxicity Reference Database (ToxRefDB). M. C. Leung1, K. McLaurin1, J. Phuong1, N. S. Sipes1, N. C. Baker1, N. C. Kleinstreuer1, A. M. Frame1, R. S. Judson1, G.R. Klinefelter2, M. T. Martin1, and T. B. 1National Center of Computational Toxicology, US EPA, RTP, NC; 2Reproductive Toxicology Division, US EPA, RTP, NC.
Poster Predicting Cellular Dynamics and Key Events in Developmental Toxicity with a Multicellular Systems Model. T. B. Knudsen1, M. R. Rountree1, S.Hunter2, N. C. Baker3, R. Spencer3, R. S. Dewoskin4, and W. Setzer1. 1NCCT, US EPA, RTP, NC; 2NHEERL, US EPA, RTP, NC; 3Lockheed Martin, RTP, NC; 4NCEA, US EPA, RTP, NC.
Workshop Talk High-Throughput Screening of Nanomaterial Bioactivity/Toxicity: The Computational Side Is Just As Important As the Testing Assays and Characterization. A. Wang. US EPA, RTP, NC.
Poster An In Silico Model of Spermatogenesis for Use in Predictive Toxicology. A. M. Frame, M. Leung, T. Knudsen, and R. S. Judson. US EPA, RTP, NC.
Poster Expansion of Toxicity Reference Database (ToxRefDB) Study Data for In Vivo Phenotypic Modeling. K. W. McLaurin, S. Sneed, I. Thillainadarajah, andand M. T. Martin. NCCT/ORD, US EPA, Durham, NC.
Poster ToxCastTM Workflow: High-Throughput Screening Assay Data Processing, Analysis and Management. P. G. Kothiya1,2, M. T. Martin1, A. Frame1, A. M. Richard1, R. S. Judson1, and D. M. Reif1. 1NCCT, Office of Research and Development, US EPA, RTP, NC; 2BioinformaticsProgram, North Carolina State University, Raleigh, NC.
Poster High-Throughput Electronic Literature Libraries (E-Libraries) to Support Development of Toxicity Prediction Models and Adverse Outcome Pathways (AOPs). N. C. Baker1, T. B. Knudsen2, and K. M. Crofton2. 1Lockheed Martin/US EPA, RTP, NC; 2NCCT, US EPA, RTP, NC.
Poster Interactive Web Application (Dashboards) to Integrate Data on Chemical Hazard and Exposure. S. Watford, M. Martin, A. Frame, R. Judson, N. Baker, I. Shah, J. Wambaugh, and D. Reif. NCCT, Office of Research and Development, US EPA, RTP, NC.
Poster ToxCast High-Throughput Screening Assay Annotation Using Bioassay Ontology and Expanded Assay Target Information. J. Phuong1,2, K. A. Houck1, and M. T. Martin1. 1NCCT, US EPA, RTP, NC; 2Environmental Science & Engineering, Univ North Carolina at Chapel Hill, Chapel Hill, NC.
Platform Talk Cell-Level Model of Morphogenetic Tissue Fusion for Computational Toxicology. M. Hutson1, and T. B. Knudsen2. 1Physics & Astronomy, Vanderbilt University, Nashville, TN; 2NCCT, US EPA, RTP, NC.
Poster Evaluating High-Throughput Exposure Models with NHANES Data. W. Setzer, and J. Wambaugh. NCCT, US EPA, RTP. NC
Symposium Talk Predictive Models of Developmental Toxicity. N. S. Sipes, and T. B. Knudsen. NCCT, US EPA, RTP. NC
Info Session Talk US EPA Computational Toxicology Predicting Cancer and Noncancer Outcomes for Cosmetics and Industrial Chemicals. N. C. Kleinstreuer. NCCT, US EPA, RTP. NC
Late Breaking Abstract Developing a Framework for Identifying Systemic Toxicity for Chemical Compounds Used in Cosmetics using ToxCast and ToxRefDB. L. Truong1, K. McLaurin1, N. Kleinstreuer1, S. Loisel‐Joubert2, G. Ouedraogo2, R. Note2, L. Le Capitaine2, H. Noçairi2, D. Dix1, and M. Martin1. I1NCCT, US EPA, Durham, NC; 2L’Oréal, Paris, France.
Poster Developing a Framework for Identifying Systemic Toxicity for Chemical Compounds Used in Cosmetics using ToxCast and ToxRefDB. L. Truong1, K. McLaurin1, N. Kleinstreuer1, S. Loisel‐Joubert2, G. Ouedraogo2, R. Note2, L. Le Capitaine2, H. Noçairi2, D. Dix1, and M. Martin1. I1NCCT, US EPA, Durham, NC; 2L’Oréal, Paris, France.
Poster Ranking and Profiling Nanomaterial (NM) Bioactivity by ToxCast High-Throughput Screening (HTS). A. Wang1, E. L. Berg2, M. Polokoff2, J. Yang2, A. El-Badawy3, D. Reif1, N. C. Kleinstreuer1, S. Marinakos4, A. Badireddy4, S. H. Gavett1, D. Rotroff1, S. Gangwal5, J. Rabinowitz1, C. Matson6, T. Tolavmat3, M. Wiesner4, and K. H. Houck1. 1ORD, US EPA, RTP, NC; 2BioSeek, LLC, San Francisco, CA; 3ORD, US EPA, Cincinnati, OH; 4CEINT, Duke University, Durham, NC; 5Xanofi, Raleigh, NC; 6Environmental Science, Baylor University, Waco, TX.
Poster Combining Pathway-Based In Vitro Assays to Prioritize 1848 Environmental Chemicals for Estrogenic Potential. D. Rotroff1,2, D. Reif1, N. Sipes1, T. Knudsen1, P. Kothia1, M. Martin1, K. Houck1, and R. Judson1. 1NCCT, US EPA, RTP, NC; 2Environmental Sciences and Engineering, Univ North Carolina at Chapel Hill, Chapel Hill, NC.
Poster CHEMOTYPES AND CHEMOTYPER: A new structure representation standard to include atomic/bond properties into structural alerts for toxicity effects and mechanisms C. Yang1,2, K. Arvidson2, A. Richard3, A. Worth4, A. Tarkhov5 , S. Ringeissen6, J. Marusczyk5, J. Gasteiger5, J. Rathman1,7, C. Schwab5 1Altamira LLC, Columbus OH; 2US FDA, CFSAN, OFAS HFS-275, College Park, MD 20740. 3 US EPA, NCCT, B205-01, RTP, NC 27711. 4 European Commission Joint Research Council, Ispra, Italy. 5 Molecular Networks, 91052 Erlangen, Germany. 6 L’Oréal Recherche, 93600 Aulnay-sous-Bois, France. 7 The Ohio State University, Columbus, OH 43210.

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