ToxCast™ Data
Data sets and published research are listed in the table below. If a free electronic copy of a research publication is not available on the table below, please contact Monica Linnenbrink (Linnenbrink.Monica@epa.gov)
| Data Set | Description | Download | Publication |
|---|---|---|---|
| Currently Available ToxCast Data | Download (0.36 MB, ZIP) |
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| Data from chemicals screened in ToxCast assays for potential endocrine disruption | Data from chemicals screened in ToxCast assays for potential endocrine disruption | Download (0.12 MB, ZIP) |
Rotroff et al (2012), Using In Vitro High-throughput Screening Assays to Identify Potential Endocrine Disrupting Chemicals, Environmental Health Perspectives |
ToxCast Phase I Data |
All concentration response data from ToxCast Phase I |
Download |
Judson et al. (2010) "In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization - The ToxCast Project" Environmental Health Perspectives |
ToxCast Phase 1 Data |
Supplemental data and figures for Judson et al |
Download |
Judson et al. (2010) "In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization - The ToxCast Project" Environmental Health Perspectives |
ToxCast Phase I Data |
Assay definitions, chemical structures and all summary AC50 and LEC values from ToxCast Phase I |
Download (0.72 MB, ZIP) |
Judson et al. (2010) "In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization - The ToxCast Project" Environmental Health Perspectives |
Xenobiotic Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by ToxCast Chemicals |
Supplemental data from this paper |
Download |
Rotroff et al. (accepted but not released) "Xenobiotic Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by ToxCast Chemicals" Journal of Toxicology and Environmental Health |
Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA's ToxCast Program |
Supplemental data from this paper, including the 48 CIS and 25 TRANS assay names and descriptions, the complete concentration response and derived AC50 values, the results of the relative risk permutation test as tables, and figures displaying the results of establishing a global Emax cutoff, the replicate analysis, and the association between PPAR and rat liver tumorigenesis. |
Download |
Martin et al. (2010) "Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA's ToxCast Program" Chemical Research in Toxicology |
Included in ToxCast Phase 1 data above |
Supplemental data from paper including ToxCast chemicals assayed at 4 concentrations in 8 BioMAP cell systems, with a total of 87 assay endpoints resulting in more than 100,000 data points. |
See above to download Toxcast Phase 1 data |
Houck et al. (2009) "Profiling Bioactivity of the ToxCast Chemical Library Using BioMAP Primary Human Cell Systems" Journal of Biomolecular Screening |
Evaluation of genotoxicity assays used in profiling ToxCast chemicals |
Supplemental data includes complete data table for profiles of all ToxCast chemicals using GreenScreen HC, CellSensor p53 and CellCiphrp53 assays with corresponding Ames and tumorogenicity data. |
Download |
Knight et al. (2009) "Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals" Regulatory Toxicology and Pharmacology Journal |
Landscape Chemicals and Assays |
Supplemental data , including the set of chemicals and data sources described in the paper "The Toxicity Data Landscape of Environmental Chemicals". (More Information) |
Download (15.5 MB, ZIP) |
Judson et al. (2008) "The Toxicity Data Landscape for Environmental Chemicals" Environmental Health Perspectives |