Benchmark Dose Software (BMDS)
BMDS Download Page
EPA's Benchmark Dose Software (BMDS) facilitates the application of benchmark dose (BMD) methods to EPA hazardous pollutant health assessments. EPA uses BMD methods to estimate points of departure for the derivation of reference values, or for the calculation of cancer slope factors, which are used along with other scientific information to set guidelines for non-cancer and cancer human health effects.
The BMDS download package includes the most current version of BMDS and ICF International's BMDS Wizard software. The BMDS Wizard simplifies BMD modeling by providing a structured interface to maintain all inputs, outputs, and decisions made in the BMD modeling process.
The Read Me file included with this download contains more information and any special instructions on getting started with BMDS and BMDS Wizard.
It is not necessary to uninstall previous versions of BMDS. However, if you want to uninstall previous versions of BMDS, it is recommended that you retain the directory structure for the folders where your previous model runs (input and output data files) reside in order to maintain the functionality of previous sessions.
Installing the Software
- Click here to save (download) the zip file for the BMDS install package (40MB, ZIP file).
- Locate the BMDS .zip file you downloaded. Typical locations for file downloads are the Windows Desktop or the Download directory in My Documents.
- In Windows Explorer, double-click the downloaded .zip file. Drag and drop the BMDS2601 folder from the .zip file to the directory of your choice on your computer.
It is recommended that you place the BMDS2601 folder (and its subfolders) in the simplest, shortest directory, without special characters or spaces, for which you have administrative rights (for most EPA users, this will be C:\Users\[EPA user's LAN ID]; for non-EPA users, this could be as simple as C:\).
- Changes, fixes, and enhancements to this version of BMDS
- Getting started with the BMDS Wizard
- BMDS zip file distribution and uninstalling versions of BMDS prior to version 2.1.2
- Determining whether BMDS is properly installed
- Creating a desktop shortcut icon
- Resolving possible issues with the Help file display
If you have problems or concerns, please use the "BMDS Support" feature listed in the "Help" menu or contact us using our Help Desk Form.
Patch to Replace 00poly.exe File Erroneously Removed by Symantec Antivirus
On August 5, 2015, Symantec distributed a virus definition update that incorrectly flagged the 00poly.exe component of BMDS as malware, and then removed or quarantined the file. This has been confirmed as a false positive, and Symantec will mark 00poly.exe as safe in their next update.
BMDS users whose 00poly.exe file has not been removed do not need to take any action. Future BMDS downloads should not trigger a Symantec alert.
However, for Symantec users whose BMDS systems were affected, the BMDS team is providing a patched version of 00poly.exe. This patch should work for any BMDS version you have on your computer. To apply the patch:
- Download 00poly_patch.zip (12KB, ZIP file).
- Copy the zip file’s contents to your BMDS2601 program folder. If you have multiple BMDS versions on your computer, copy the patched file to all other BMDS program folders.
We apologize for any inconvenience this may have caused. Please contact us if you have any further questions or concerns.
This BMDS version is being released for use by risk assessors as the official BMDS system. BMDS requires at least 16 Megabytes of RAM and should run in Microsoft Windows 2000, NT, XP, Vista, 7, and 8, however only operation in Windows XP and Windows 7 has been fully tested at this time.
BMDS also requires Microsoft .NET 4.0 or later. If your machine is set up to allow or be notified of downloads of Microsoft software, then it is likely that that version of the .NET framework is already installed. Otherwise, the latest version of .NET for client desktops can be downloaded from http://www.microsoft.com/net/downloads.
To run the ToxicoDiffusion model included in this version of BMDS, you must install the 32-bit edition of version 3.1 or later of the R statistical software to your computer (go to http://www.r-project.org/ for more information).
Receive Notifications of Updates or Information
Registration is not required to download the software. However, if you would like to receive a notification when new releases or important information becomes available, please register on the download page. We also offer the C source code files for the individual models used in the BMDS system to reviewers/programmers that might be interested in performing an in-depth analysis of the model algorithms and features. We welcome, in fact encourage, comments, recommendations, suggested revisions, or corrections, through our Help Desk Form.
To obtain older versions of BMDS, send an e-mail to firstname.lastname@example.org with your request, including the BMDS version you would like to receive.
BMDS Model Technical Background Documents
ToxicoDiffusion Model Documentation
ten Berge Model Documentation
The following ten Berge documentation and reviewer comment files are available for downloading.
- Click here to download the ten Berge model documentation file (PDF) (89pp, 756 KB, about PDF)
- Click here to download the ten Berge model peer review comments (PDF) (26pp, 94.4 KB, about PDF)
Multitumor (MS_Combo) Model Documentation
The following multitumor model technical background documentation is available for downloading.
- Click here to download the multitumor model technical background document (PDF) (2pp, 200 KB, about PDF)
- Click here to download EPA technical guidance for choosing the appropriate stage of a multistage model for cancer modeling (PDF) (6pp, 465 KB, about PDF)
Multistage Weibull Time-to-Tumor Software and Documentation
The following Multistage Weibull (MSW) Time-to-Tumor model technical background documentation and peer review comments are available for downloading, including the original model executable and instructions.
- Click here to download the MSW time-to-tumor model executable, user manual, spreadsheet data template, and sample data and output files (378KB, ZIP file)
- Click here to download the MSW time-to-tumor model peer review comments and response (PDF) (also includes review of other models) (16 pp, 212KB, about PDF)
- Click here to download the MSW time-to-tumor model technical documentation files (1.32MB, ZIP file)