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Benchmark Dose Software (BMDS)

Benchmark Dose Modeling – Advanced Topics

Organizers: J. Allen Davis

Instructors: J. Allen Davis, MSPH, US Environmental Protection Agency (EPA); Jeff Gift (EPA)

Preliminary Date: June 25th, 2013

The objectives of this full-day course are to provide participants with training on how to use EPA’s Benchmark Dose Modeling Software (BMDS) and other software programs to facilitate advanced BMD analyses in risk assessments. Specifically, this course will demonstrate how to use the following advanced BMD models, and will provide fundamental understanding of the approach and model-framework used for the models:

  • The MS_Combo model for assessing the risk of developing any number of independent tumors in a single bioassay
  • The Multistate Weibull Time-to-Tumor (MSW) model for cancer analyses when survival rates are observed to differ due to exposure
  • The Toxicodiffusion model for analyzing repeated response data common to many neurotoxicity test guidelines
  • Categorical Regression (CatReg) modeling for analyzing data for multiple endpoints from multiple bioassays and multiple species simultaneously

This course will be given as both an in-person and web-based workshop. In-person attendance is limited to 40 people (with preference given to local EPA and RTP employees). Webinar attendance is limited to 50 people. To register for this course, please contact Allen Davis (919-541-3789 or davis.allen@epa.gov) and indicate whether you are interested in attending in-person or via webinar.

Participants are expected to have a general understanding of basic benchmark dose methods, either through work-related experience, or previous completion of at least the introductory portion of online training courses (http://epa.gov/ncea/bmds/training/index.html).

Participants need to bring their own laptops to the workshop with BMDS 2.4, the Multistage Weibull executable, CatReg 2.1, and the R statistical package installed (with necessary administrative rights). The latest version of the software programs can be found at: http://epa.gov/ncea/bmds/, epa.gov/ncea/catreg, and http://www.r-project.org/.

Specific installation instructions for the software programs can be found on the websites or in documentation that can be downloaded from the websites.

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