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Inorganic Arsenic Meetings & Webinars

UPDATE: NRC released an Interim Report on inorganic arsenic - November 7, 2013.

EPA is announcing a series of public meetings and webinars on the Integrated Risk Information System (IRIS) Toxicological Review of Inorganic Arsenic. These events are designed to inform the planning for EPA’s toxicological review of chronic exposure to inorganic arsenic (iAs) (cancer and non-cancer effects), which EPA intends to post to the Integrated Risk Information System (IRIS) database.

Environmental protection decisions, based in part on EPA's IRIS assessments, can have potentially large impacts on the environment, human health and the economy. Because of this, it is important that EPA benefit from stakeholder and scientific engagement to support the best decisions possible. If you were not able to attend, please take an opportunity to review the presentations included below.

Arsenic Webinar Series:

Note: Contact us to request a copy of any of the webinar series presentations.

July 31, 2013: Is Arsenic a Mutagenic Carcinogen? Investigations Into its Mode of Action

Invited Speaker: Dr. Andrew Kligerman

Biography: Dr. Andrew Kligerman is currently a research biologist in the Integrated Systems Toxicology Division at the U.S. EPA in Research Triangle Park, NC. He has been a cytogeneticist and genetic toxicologist at the EPA for over 24 years. His research interest focuses on studying the genotoxicity of important environmental and commodity chemicals. For the previous 10 years his research has concentrated on investigating the mode of action of arsenicals in inducing genetic damage and cancer. He is currently doing a rotation with the National Center for Computational Toxicology at the EPA, where he is investigating the sensitivity and specificity of high-throughput tests for determining the genetic toxicology of chemicals.

June 26, 2013: Environmental Justice

Invited Speaker: Michele Roberts

Biography: Michele Roberts is currently co-director of the Environmental Justice and Health Alliance for Chemical Policy Reform. Since 1990, Ms. Roberts has provided technical assistance and advocacy support to communities regarding the impacts of toxins on human health and the environment. She also is a spoken word artist, who created Arts Slam @ SsAMS, a community-based arts program. She received a master of art degree (2000) from the University of Delaware and a bachelor of science degree in biology (1983) from Morgan State University. Ms. Roberts has co-authored reports on environmental justice issues. Her advocacy work has been featured in television, print news, and magazines. Prior to being an advocate, Michele worked for 20 years as an environmental scientist for the government.

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May 22, 2013: Arsenic and Children’s Neurodevelopment: What is the Literature Telling Us?

Invited Speaker: Dr. David Bellinger

Biography: Dr. Bellinger is a Senior Research Associate in Neurology and Professor of Neurology at Boston Children’s Hospital. He holds a secondary appointment as Professor in the Department of Environmental Health at the Harvard School of Public Health. Dr. Bellinger is currently President of the International Society for Children’s Health and the Environment.
Dr. Bellinger's research focuses on two types of early insults to the developing nervous system—chemical exposures (e.g., lead, elemental mercury, methylmercury, arsenic, manganese, pesticides and anesthetic agents) and insults related to serious medical conditions (e.g., congenital heart lesions, schistosomiasis and congenital diaphragmatic hernia).

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May 8, 2013: Mode of Action of Arsenical Carcinogenesis

Invited Speaker: Dr. Samuel Cohen

Biography: Dr. Cohen is currently a Professor in the Department of Pathology and Microbiology at the University of Nebraska Medical Center. Dr. Cohen’s research has focused on mechanisms of carcinogenesis, with a focus on the role of cell proliferation in the carcinogenic process, primarily utilizing the urinary bladder as a model system. Most recently this has involved investigations into the mechanisms of bladder carcinogenesis produced by arsenicals and PPAR agonists. In addition, his research has involved clinical investigations of various aspects of urologic pathology and extrapolation between animals and humans.

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April 24, 2013: Recent Developments in Adverse Outcome Pathway/Mode of Action Analysis

Invited Speaker: Dr. Bette Meek

Biography: Dr. Meek is currently the Associate Director of Chemical Risk Assessment at the McLaughlin Centre for Population Health Risk Assessment, University of Ottawa. She has extensive experience in the conduct and management of chemical risk assessments within the Government of Canada. Specific areas of experience include the development of frameworks for weight of evidence analysis including mode of action, chemical specific adjustment factors, physiologically-based pharmacokinetic modeling, combined exposures and predictive modeling.

April 11, 2013: Inorganic Arsenic Exposure and Hypertension: A Focus on Blood Pressure Reactivity

Invited Speakers: Drs. Catherine W. Yeckel and Kathleen McCarty

Biography: Dr. Yeckel is an associate research scientist and lecturer in epidemiology at the Yale School of Public Health. Dr. Yeckel’s research focuses on physiological mechanisms of human metabolism in health and disease. Her research interests include obesity, insulin resistance, and exercise training.

Dr. McCarty is currently an assistant director in epidemiology at Biogen Idec in Cambridge and an adjunct faculty at Yale School of Medicine. Prior to joining Biogen, Dr. McCarty was an assistant professor at the Yale School of Public Health where her main research projects involve environmental cofactors, genetic susceptibility, arsenic exposure and health outcomes, gene-environment interactions and breast cancer risk, and biomarker development.

March 27, 2013: Transplacental Arsenic Carcinogenesis and Stem Cells

Invited Speaker: Dr. Erik Tokar

Biography: Dr. Tokar is a biologist in the Inorganic Toxicology Group at NIEHS. His major research interests involve the role of stem cells in inorganic carcinogenesis, with an emphasis on arsenic and cadmium. His research also focuses on the role of stem cells in the developmental basis of adult diseases, such as cancer.

March 20, 2013: Considerations in Assessing Low-Level Exposure to Arsenic in Drinking Water

Invited Speaker: Dr. Jaymie Meliker

Biography: Dr. Meliker is an associate professor of Preventive Medicine in the Division of Evaluative Sciences at Stony Brook University Medical Center. Dr. Meliker’s research contributes to the fields of exposure science, health geography, and environmental epidemiology. He is interested in identifying environmental factors that play important roles in disease morbidity and developing space-time methods that improve our ability to investigate exposure-disease relationships.

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