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UC Berkeley Center for Children's Environmental Health Research -- Additional Studies
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CHAMACOS Paraoxonase (PON1) Polymorphism Study: This study investigated variability in susceptibility to organophosphate (OP) pesticide poisoning due to polymorphisms in PON1, which detoxify OP compounds. This study was a collaboration of the UC Berkeley NIEHS Core Center (Martyn Smith, PI), the UW NIEHS Core Center (Center for Ecogenetics and Environmental Health - David Eaton, PI) and the UW Center for Child Environmental Health Risks Research (Elaine Faustman, PI), and was funded as a supplement to the NIEHS Core Centers.
Pesticides in Amniotic Fluid Pilot Study: This study investigated the feasibility of measuring non-persistent pesticides in amniotic fluid as a biomarker of fetal exposures. Dr. Asa Bradman initiated pilot studies to test for organophosphate, pyrethroid, and carbamate pesticides in this medium with Dr. Dana Barr, CDC. Pilot funding was obtained through the UC Berkeley NIEHS Core center (Martyn Smith, PI), and utilized CHAMACOS infrastructure to collect, label, ship, and track the samples.
Quantitative Exposure Assessment – EPA National Exposure Research Laboratory (NERL): WithNERL, CHAMACOS conducted an intensive pesticide exposure pilot study to test field sampling methods and instruments to support planning for the National Children’s study, a longitudinal cohort study of approximately 100,000 American children.
Non-persistent pesticides in breastmilk: Rosana Hernandez Weldon, an MPH/PhD student working with CHAMACOS, successfully obtained an EPA STAR Fellowship to develop analytical methods for measuring non-persistent pesticides in breastmilk. She is working under the supervision of Dr. Jeffrey Morgan, EPA Regional Lab in Cincinnati and Dr. Dana Barr, Laboratory Division of CDC.
EPA Region IX collaboration on pesticides in vehicle dust: We initiated a pilot study investigating pesticide residues in participant vehicles with Ray Chavira, UCLA doctoral candidate and pesticide specialist at EPA Region IX.
American Academy for Allergy, Asthma, and Immune Disease (AAAI): With AAAI and the Salinas Allergy Clinic, we established a Burkard monitoring station in Salinas to measure ambient pollen and mold levels. These measurements are made available to local physicians through the Salinas Allergy Clinic, the local newspaper, and our web site (www.chamacos.org), and also provided to the AAAI for their surveillance program.
California Department of Health Services: With the Childhood Lead Poisoning Prevention Branch, blood lead levels in maternal and cord blood samples were measured to characterize exposures to this underserved population and control for confounding in the pesticide health effects study.
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