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Center for the Study of Environmental Factors in the Etiology of Autism Publications
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Aleman M, Riehl J, Aldridge BM, Lecouteur RA, Stott JL, Pessah IN. Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermia. Muscle and Nerve 2004;30(3):356-365.
Abstract
Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water JA. Plasma leptin levels are elevated in autism: Association with early onset phenotype? 2006.
Ashwood P, Van de Water J. "Is autism an autoimmune disease?" Autoimmun Rev 2004;3(7-8): 557-562.
Abstract
Ashwood P, Van de Water J. "A review of autism and the immune response." Clin Dev Immunol 2004;11(2):165-174.
Ashwood P, Wills S, Van de Water J. The immune response in autism: a new frontier for autism research. Journal of Leukocyte Biology 2006;80(1):1-15.
Abstract
Aronov PA, Dettmer K, Christiansen JA, Cornel AJ, Hammock BD. Development
of a HPLC/tandem-MS method for the analysis of the larvicides methoprene,
hydroprene and kinoprene at trace levels using Diels-Alder derivatization. Journal
of Agricultural and Food Chemistry 2005;53:3306-3312.
Abstract | Full-Text (PDF) (20 pp, 126 K)
Baron CA, Liu SY, Hicks C, Gregg JP. Utilization of Lymphoblastoid Cell Lines as a System for the Molecular Modeling of Autism. J Autism Dev Disord 2006.
Abstract
Baron CA, Tepper CG, Liu SY, Davis RR, Wang NJ, Schanen NC, Gregg JP.
Genomic and functional profiling of duplicated chromosome 15 cell lines
reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome
pathway processes. Human Molecular Genetics 2006;15:853-869.
Abstract
Bauman MD, Lavenex P, Mason WA, Capitanio JP, Amaral DG. The development
of social behavior following neonatal amygdala lesions in rhesus monkeys. Journal of Cognitive Neuroscience 2004;16:1388-1411.
Abstract
Bu B, Ashwood P, Harvey D, King IB, Water JV, Jin LW. Fatty acid
compositions of red blood cell phospholipids in children with autism. Prostaglandins
Leukotrienes and Essential Fatty Acids 2006;74(4):215-221.
Abstract
Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock
BD, Roth JR, Anderson PJ. Human vitamin B12 absorption measurement
by accelerator mass spectrometry using specifically labeled (14)C-cobalamin. Proceedings
of the National Academy of Sciences, USA 2006;103(15):5694-5699.
Abstract | Full-Text (PDF) (6 pp, 921 K)
Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah
IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. Heat- and
anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB
Journal 2006;20(2):329-330.
Abstract
Chen L, Estýýve E, Sabatier JM, Ronjat M, De Waard M, Allen
PD, Pessah IN. Maurocalcine and peptide A stabilize distinct subconductance
states of ryanodine receptor type 1 (RyR1) revealing a proportional gating
mechanism. Journal of Biological Chemistry 2003;278(18):16095-16106.
Abstract
Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates
calcium-induced calcium release. Circulation Research 2004;94(4):478-86.
Abstract
Cherednichenko G, Hurne A, Fessenden JD, Lee EH, Allen PD, Beam KG, and
Pessah IN. Conformational activation of Ca2+ entry by depolarization
of skeletal myotubes. Proceedings of the National Academy of Sciences,
USA 2004;101(44):15793–15798.
Abstract | Full-Text (PDF) (6 pp, 424 K)
Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J. Maternal
autoimmune diseases, asthma and allergies, and childhood autism spectrum
disorders: a case-control study. Archives of Pediatrics & Adolescent
Medicine 2005;159:151-157.
Abstract
Dai JJ, Lieu L, Rocke D. Dimension reduction for classification with
gene expression microarray data. Stat Appl Genet Mol Biol 2006;5(1):Article 6.
Abstract
Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH.
Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl
urea is independent of soluble epoxide hydrolase inhibition. Journal
of Pharmacology and Experimental Therapeutics 2006;316:815-821.
Abstract
Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH.
Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle
cell proliferation. Proceedings of the National Academy of Sciences,
USA 2002;99:2222-2227.
Abstract | Full-Text (PDF) (6 pp, 292 K)
Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. Altered kidney CYP2C and increased Cyclooxygenase-2 levels are associated with obesity-related Albuminuria. Obesity Research 2004;12:1278-1289.
Abstract | Full-Text (PDF) (12 pp, 314 K)
Dietrich KM, Eskenazi B, Shantz S, Yolton K, Rauh VA, Johnson CB, Alkon
A, Canfield RL, Pessah IN, Berman RF. Principles and practices of
neurodevelopmental assessment in environmental health: From the Centers
for Children’s Environmental Health and Disease prevention research. Environmental
Health Perspectives 2005;113(10):1437-1446.
Abstract | Full-Text (PDF) (9 pp, 145 K)
Du X, Tang Y, Xu H, Lit L, Walker W, Ashwood P, Gregg JP, Sharp FR.
Genomic profiles for human peripheral blood T cells, B cells, natural killer
cells, monocytes, and polymorphonuclear cells: comparisons to ischemic
stroke, migraine, and Tourette syndrome. Genomics 2006;87(6):693-703.
Abstract
DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD,
Miller MG. Epoxide hydrolases in the rat epididymis: possible roles
in xenobiotic and endogenous fatty acid metabolism. Toxicological
Sciences 2004;78(2):187-195.
Abstract | Full-Text (PDF) (9 pp, 213 K)
Estýýve E, Smida-Rezgui S, Sarkozi S, Szegedi C, Regaya
I, Chen L, Altafaj X, Rochat H, Allen P, Pessah IN, Marty I, Sabatier
JM, Jona I, De Waard M, Ronjat M. Critical amino acid residues determine
the binding affinity and the Ca2+ release efficacy of maurocalcine in
skeletal muscle cells. Journal of Biological Chemistry 2003;278:37822-37831.
Abstract | Full-Text (PDF) (10 pp, 608 K)
Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy
JY, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated
receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. Journal
of Pharmacology and Experimental Therapeutics 2005;314:260-270.
Abstract | Full-Text (PDF) (11 pp, 564 K)
Fang X, Weintraub NL, McCaw RB, Hu S, Harmon SD, Rice JB, Hammock BD, Spector AA. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. American Journal of Physiology-Heart and Circulatory Physiology 2004;287:H2412-H2420.
Abstract | Full-Text (PDF) (9 pp, 656 K)
Fang X, Weintraub NL, Oltman CL, Stoll LL, Kaduce TL, Harmon S, Dellsperger
KC, Morisseau C, Hammock BD, Spector AA. Human coronary endothelial cells
convert 14,15-EET to a biologically active chain-shortened epoxide. American
Journal of Physiology-Heart and Circulatory Physiology 2002;283(6):H2306-H2314.
Abstract | Full-Text (PDF) (10 pp, 412 K)
Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN. Homer
regulates gain of ryanodine receptor type 1 channel complex. Journal
of Biological Chemistry 2002;277(47):44722-44730.
Abstract | Full-Text (PDF) (9 pp, 358 K)
Gafni J, Wong PW, Pessah IN. Noncoplanar 2,2’,3,5’,6-pentachlorobiphenyl
(PCB 95) and rapamycin amplify ryanodine receptor signaling and Ca2+ entry
mediated by ionotrophic glutamate receptors in cerebellar granule neurons. Toxicological
Sciences 2004;77(1):72-82.
Abstract | Full-Text (PDF) (10 pp, 408 K)
Gao J, Voss AA, Pessah IN, Lauer FT, Penning TM, Burchiel SW. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicological Sciences 2005;87:419-426.
Abstract | Full-Text (PDF) (8 pp, 403 K)
Geller SC, Gregg JP, Hagerman P, Rocke DM. Transformation and normalization
of oligonucleotide microarray data. Bioinformatics 2003;19(14):1817-1823.
Abstract | Full-Text (PDF) (7 pp, 261 K)
German JB, Hammock BD, Watkins SM. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 2005;1(1):3-9.
Abstract | Full-Text (PDF) (9 pp, 73 K)
German JB, Watkins SM, Fay LB. Metabolomics in practice: Emerging knowledge to guide future dietetic advice toward individualized health. J Am Diet Assoc 2005;105(9):1425-1432.
Abstract
Gibney MJ, Walsh M, Brennan L, Roche HM, German B, van Ommen B. Metabolomics in human nutrition: opportunities and challenges. American Journal of Clinical Nutrition 2005;82(3):497-503.
Abstract | Full-Text (PDF) (7 pp, 228 K)
Goth SR, Cherednichenko G, Chu RA, Pessah IN. Nanomolar ethyl mercury and thimerosal alter murine dendritic cells function in vitro. 2004. (Submitted)
Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN. Uncoupling
of ATP-Mediated Calcium Signaling and Dysregulated Interleukin-6 Secretion
in Dendritic Cells by Nanomolar Thimerosal. Environmental Health Perspectives 2006;114(7):1083-1091.
Abstract | Full-Text (PDF) (12 pp, 301 K)
Goth SR, Chu RA, Pessah IN. Oxygen tension regulates the maturation
of GM-CSF expanded murine bone marrow dendritic cells by modulating class
II MHC expression. Journal of Immunological Methods 2006;308(1-2):179-191.
Abstract | Full-Text (PDF) (13 pp, 491 K)
Greco CM, Berman RF, Martin RM, Tassone F, Schwartz PH, Chang A, Trapp
BD, Iwahashi C, Brunberg J, Grigsby J, Hessl D, Becker EJ, Papazian J,
Leehey MA, Hagerman RJ, Hagerman PJ. Neuropathology of fragile X-associated
tremor/ataxia syndrome (FXTAS). Brain 2006;129(Pt
1):243-255.
Abstract
Hansen ME, Pessah IN, Matsumura F. Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells. Toxicology 2006;220:218-231.
Abstract | Full-Text (PDF) (13 pp, 490 K)
Hertz-Picciotto I, Charles MJ, James RA, Keller JA, Willman E, Teplin
S. In utero polychlorinated biphenyl exposures in relation to fetal and
early childhood growth. Epidemiology 2005;16:648-656.
Abstract
Hertz-Picciotto I, Croen LA, Hansen R, Jones CR, van de Water J, Pessah
IN. The CHARGE Study: An Epidemiologic Investigation of Genetic
and Environmental Factors Contributing to Autism. Environmental Health
Perspectives 2006;114(7):1119-1125.
Abstract | Full-Text (PDF) (6 pp, 130 K)
Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. Polychlorinated
biphenyls induce caspase-dependent cell death in cultured embryonic rat
hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicology
and Applied Pharmacology 2003;190(1):72-86.
Abstract | Full-Text (PDF) (15 pp, 560 K)
Huang H, Nishi K, Gee SJ, Hammock BD. Evaluation of chiral alpha-cyanoesters
as general fluorescent substrates for screening enantioselective esterases. Journal
of Agricultural and Food Chemistry 2006;54:694-699.
Abstract | Full-Text (PDF) (14 pp, 205 K)
Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD. Development of optically
pure pyrethroid-like fluorescent substrates for carboxylesterases. Chemical
Research in Toxicology 2005;18:516-527.
Abstract
Hurne AM, O'Brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG,
Pessah IN. Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S
reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic
reticulum store depletion. Journal of Biological Chemistry 2005;280:36994-37004.
Abstract | Full-Text (PDF) (11 pp, 729 K)
Inceoglu B, Lango J, Jing J, Chen L, Doymaz F, Pessah IN, Hammock BD. One scorpion, two venoms: Prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proceedings of the National Academy of Sciences, USA 2003;100:922-927.
Abstract | Full-Text (PDF) (6 pp, 234 K)
Inceoglu B, Lango J, Pessah IN, Hammock BD. Three structurally
related, highly potent, peptides from the venom of Parabuthus transvaalicus
possess divergent biological activity. Toxicon 2005;45:727-733.
Abstract | Full-Text (PDF) (7 pp, 279 K)
Jaubert P, Golub MS, Lo Y, Germann SL, Worley PF and Berman RF. Complex, multimodal behavioral profile of the Homer 1 knockout mouse. Genes, Brain and Behavior.
Abstract
Kenet T, Froemcke R, Schreiner C, Pessah IN, Merzenich MM. Abnormal auditory cortex development in PCB exposed rats. Proceedings of the National Academy of Sciences of the United States of America.
Kim IH, Heirtzler FR, Morisseau C, Nishi K, Tsai HJ, Hammock BD. Optimization
of amide-based inhibitors of soluble epoxide hydrolase with improved water
solubility. Journal of Medicinal Chemistry 2005;48:3621-3629.
Abstract | Full-Text (PDF) (19 pp, 597 K)
Kim IH, Morisseau C, Watanabe T, Hammock BD. Design, synthesis, and biological
activity of 1,3-disubstituted ureas as potent inhibitors of the soluble
epoxide hydrolase of increased water solubility. Journal of Medicinal
Chemistry 2004;47(8):2110-2122.
Abstract
Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich
JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. Formulation and
Characterization of an experimental PCB mixture designed to mimic human
exposure from contaminated fish. Toxicological Sciences 2005;88:400-411.
Abstract
Lawler CP, Croen LA, Grether JK, Van de Water J. Identifying environmental contributions to autism: provocative clues and false leads. MRDD Research Reviews 2004;10:292-302.
Abstract
Li L. Survival prediction of diffuse large-B-cell lymphoma based
on both clinical and gene expression information. Bioinformatics 2006;22(4):466-471.
Abstract
Li L, Li H. Dimension Reduction Methods for Microarrays with
Application to Censored Survival Data. Bioinformatics 2004;20:3406-3412.
Abstract | Full-Text (PDF) (7 pp, 126 K)
Masuno MN, Pessah IN, Olmstead MM, Molinski T. Simplified cyclic analogs
of bastadin-5. Structure-activity relationships of modulation of the RyR1/FKBP12
Ca2+ channel. Journal of Medicinal Chemistry 2006;49:4497-4511.
Abstract
Newman JW, Morisseau C, Hammock BD. Epoxide hydrolases: Their roles
and interactions with lipid metabolism. Progress in Lipid Research 2005;44:1-51.
Abstract
Newman JW, Morisseau C, Harris TR, Hammock BD. The soluble epoxide hydrolase
encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase
activity. Proceedings of the National Academy of Sciences, USA 2003;100(4):1558-1563.
Abstract | Full-Text (PDF) (6 pp, 168 K)
Newman JW, Watanabe T, Hammock BD. The simultaneous quantification of
cytochrome P450 dependent linoleate and arachidonate metabolites in urine
by HPLC-MS/MS. Journal of Lipid Research 2002;43(9):1563-1578.
Abstract | Full-Text (PDF) (16 pp, 1338 K)
Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do Z, Kim KH, Wong PW. Structure-activity relationship for noncoplanar polychlorinated
biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex
type 1 (RyR1). Chemical Research in Toxicology 2006;9(1):92-101.
Abstract
Riehl J, Pessah IN. 2,2’-Dibromodiphenyl Ether Selectively Enhances the Activity of the Skeletal Isoform of the Ryanodine Receptor (RyR1). 2006.
Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY,
Greenough WT, Pessah IN, Schantz SL. Purkinje cell and cerebellar
effects following developmental exposure to PCBs and/or MeHg. Neurotoxicology
and Teratology 2006;28(1):74-85.
Abstract | Full-Text (PDF) (12 pp, 213 K)
Schmelzer KR, Kubala L, Newman JW, Kim IH, Eiserich JP, Hammock BD. Soluble
epoxide hydrolase is a therapeutic target for acute inflammation. Proceedings
of the National Academy of Sciecnes, USA 2005;102:9772-9777.
Abstract | Full-Text (PDF) (6 pp, 464 K)
Shan G, Lipton C. Immunoassays, biosensors, and other nonchromatographic methods. Handbook of Residue Analytical Methods for Agrochemicals. P. W. Lee. Chichester, John Wiley & Sons, Ltd.: 2002;623-679.
Shearer GC, Newman JW, Hammock BD, Kaysen GA. Graded effects of proteinuria
on HDL structure in nephrotic rats. J Am Soc Nephrol 2005;16:1309-1319.
Abstract | Full-Text (PDF) (11 pp, 431 K)
Smith KR, Pinkerton KE, Watanabe T, Pedersen TL, Ma SJ, Hammock BD. Attenuation
of tobacco smoke-induced lung inflammation by treatment with a soluble
epoxide hydrolase inhibitor. PNAS 2005;102:2186-2191.
Abstract | Full-Text (PDF) (6 pp, 314 K)
Ta TA, Feng W, Molinski TF, Pessah IN. Hydroxylated xestospongins
block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize
Ca2+-induced Ca2+ release mediated by ryanodine receptors. Mol Pharmacol 2006;69(2):532-538.
Abstract
Ta TA, Pessah IN. Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). Neurotoxicology. 2006.
Abstract
Viswanathan S, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig
B. Involvement of CYP 2C9 in mediating the proinflammatory effects of
linoleic acid in vascular endothelial cells. Journal of American College
Nutrition 2003;22(6):502-510.
Abstract | Full-Text (PDF) (9 pp, 964 K)
Voss AA, Lango J, Ernst-Russell M, Morin D, and Pessah IN. Identification
of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. Journal
of Biological Chemistry 2004;279(33):34514-34520.
Abstract | Full-Text (PDF) (7 pp, 330 K)
Ward RE, Niýýonuevo M, Mills DA, Lebrilla CB, German JB .
In vitro fermentation of breast milk oligosaccharides by Bifidobacterium
infantis and Lactobacillus gasseri. Applied Environmental Microbiology 2006;72:4497-4499.
Abstract | Full-Text (PDF) (3 pp, 101 K)
Ward CW, Feng W, Tu J, Pessah IN, Worley PK, Schneider MF. "Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle." J Biol Chem 2004;279(7): 5781-5187.
Yang T, Riehl J, Esteve E, Matthaei KI, Goth SR, Allen PD, Pessah IN, Lopez JR. Pharmacolic and functional characterization of malignant hyperthermia in the R163C-RYR1 knock-in mouse. Anesthesiology 2006.
Yang W, Yaoi T, Huang S, Yang Q, Hatcher S, Seet H, Gregg JP. Detecting the C282Y and H63D mutations of the HFE gene by Holliday Junction-based allele-specific genotyping methods. Clinical Chemistry 2005;51(1):210-213.
Zhao X, Yamamoto T, Newman JW, Kim IH, Watanabe T, Hammock BD, Stewart
J, Pollock JS, Pollock DM, Imig JD. Soluble epoxide hydrolase inhibition
protects the kidney from hypertension-induced damage. J Am Soc Nephrol 2004;15(5):1244-1253.
Abstract | Full-Text (PDF) (10 pp, 837 K)
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