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University of Iowa Children's Environmental Airway Disease Center (1998-2003) Publications
Peer-Reviewed
Ackermann LA, Wollenweber LA, Denning GM. IL-4 and IFN-g Increase Steady State Levels of pIgR in Human Airway and Intestinal Epithelial Cells. The Journal of Immunology, 162(9):5112-5118, 1999. Abstract | Full-Text (PDF) (7 pp, 136 K) | PubMed
Ahrens RC, Hendeles L, Clarke WR, Dockhorn RJ, Hill MR, Vaughan LM, Lux C, Han H. Therapeutic equivalence of Spiros DPI and Ventolin MDI: A bioassay using methacholine. American Journal of Respiratory and Critical Care Medicine, 160:1238-1243, 1999.
Ahrens RC, Teresi ME, Han S-H, Donnell D, Vanden Burgt JA, Lux CR. Asthma stability after oral prednisone: A clinical model for comparing inhaled steroid potency. American Journal of Respiratory and Critical Care Medicine, 164(7):1138-1145, 2001. Abstract | Full-Text (PDF) (8 pp, 122 K) | PubMed
Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genetics, 2000 Jun;25(2):187-91. Abstract | Full-Text (PDF) (5 pp, 965 K) | PubMed
Balmes J, Becklake M, Blanc P, Henneberger P, Kreiss K, Mapp C, Milton D, Schwartz D, Toren K, Viegi G. ATS statement on occupational contribution to the burden of airway disease. American Journal of Respiratory and Critical Care Medicine, 2003; 167(5):787-797.
Bauer EP, Romitti PA, Reynolds SJ. Evaluation of reports of periconceptual occupational exposure: Maternal-assessed versus industrial hygiene-assessed exposure. American Journal of Industrial Medicine, 36:573-578, 1999.
Becker S, Clapp WD, Quay J, Frees KL, Koren HS, Schwartz DA. Compartmentalization of the inflammatory response to inhaled grain dust. American Journal of Respiratory and Critical Care Medicine, 1999; 160(4): 1309-1318. Abstract | Full-Text (PDF) (10 pp, 308 K) | PubMed
Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA. Subchronic endotoxin inhalation causes chronic airway disease. American Journal of Physiology: Lung Cellular and Molecular Physiology, 285:L755-L761, 2003.
Butler N.S., Monick M.M., Yarovinsky T.O., Powers L.S., Hunninghake G.W.: Altered IL-4 mRNA stability correlates with Th1/Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. The Journal of Immunology, 169(7):3700-3709, 2002. Abstract | Full-Text (PDF) (10 pp, 224 K) | PubMed
Carter A. B., Tephly L.A., Hunninghake G.W.: The absence of activator protein 1-dependent gene expression in THP-1 macrophages stimulated with phorbol esters is due to lack of p38 mitogen-activated protein kinase activation. Journal of Biological Chemistry, 276(36):33826-33832, 2001. Abstract | Full-Text (PDF) (7 pp, 354 K) | PubMed
Carter A.B., Hunninghake G.W. A constitutive active MEK® ERK pathway negatively regulates NF- k B-dependent gene expression by modulating TBP phosphorylation. Journal of Biological Chemistry, 275:27858-27864, 2000.
Carter A.B., Knudtson K.L., Monick M.M., Hunninghake G.W. The P38 mitogen-activated protein kinase is required for NF- kB-dependent gene expression. The role of TATA-binding protein (TBP). Journal of Biological Chemistry, 274:30858-30863, 1999.
Carter A.B., Monick M.M., Hunninghake G.W. Lipopolysaccharide-induced NF- κB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent. American Journal of Respiratory Cell and Molecular Biology, 18(3):384-391, 1998. Abstract | Full-Text (PDF) (8 pp, 195 K) | PubMed
Carter A.B., Monick M.M., Powers L.S., Hunninghake G.W. Both ERK and P38 kinases are necessary for cytokine gene transcription. American Journal of Respiratory Cell and Molecular Biology, 20(4):751-758, 1999. Abstract | Full-Text (PDF) (8 pp, 274 K) | PubMed
Chen W., Hunninghake G.W. Effects of ragweed and Th-2 cytokines on the secretion of IL-8 by human airway epithelial cells. Experimental Lung Research, 26(4):229-239, 2000. Abstract | PubMed
Chen W., Monick M.M., Carter A.B. and Hunninghake G.W. Activation of ERK kinase activity by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8. Experimental Lung Research, 26(1):13-26, 2000. Abstract | PubMed
Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J. Asthma prevalence and morbidity among rural Iowa schoolchildren. Journal of Allergy and Clinical Immunology, 2004; 113(3): 66-71 (Vol. 113, No. 3, Page 391) Abstract | Full-Text (PDF) (6 pp, 81 K) | PubMed
Chrischilles EA, Gilden D, Kubisiak J, Rubenstein L, Shah H. Delivery of Ipratropium and Albuterol Combination Therapy for Chronic Obstructive Pulmonary Disease: Effectiveness of a Two-in-One Inhaler vs. Separate Inhalers. American Journal of Managed Care, 8(10):902-911, 2002. Abstract | Full-Text (PDF) (10 pp, 548 K) | PubMed
Chun DT, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson B, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown ME. Preliminary report on the results of the first phase of a round robin endotoxin assay study using cotton dust. In: Dugger P, Richter DA, editorial coordinators. 1998 Proceedings of the Beltwide Cotton Conferences; Jan 5-9; San Diego, CA. National Cotton Council of America, Memphis, TN. 1:195-198, 1998.
Chun DT, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson B-M, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown ME. Preliminary report on the results of the second phase of a round-robin endotoxin assay study using cotton dust. Applied Occupational and Environmental Hygiene, 15(1):152-157, 2000. Abstract | PubMed
Chun DT, Chew V, Gordon T, Jacobs RR, Larsson B-M, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown M. A quick summary of the highlights of parts 1 and 2 of the first round robin endotoxin assay study and a brief preview of the next round. Pages 132-138, in: 1999 Proceedings of the Beltwide Cotton Conferences; Vol. 1, Jan 3-7; Orlando, FL. (Paul Dugger, Deborah A. Richter, Editorial Coordinators). National Cotton Council of America, Memphis, TN, Pp. 1-754; 1999.
Chun DTW, Chew V, Bartlett K, Gordon T, Jacobs RR, Larsson B-M, Larsson L, Lewis DM, Liesivuori J, Michel O, Milton DK, Rylander R, Thorne PS, White EM, Brown ME. A round robin endotoxin assay study using cotton dust. Journal of Occupational and Environmental Hygiene, 2002, In Press.
Denning GM, Railsback MA, Rasmussen GT, Cox CD, Britigan BE. Pseudomonas Pyocyanine Alters Calcium Signaling in Human Airway Epithelial Cells. American Journal of Physiology, 274(6 pt 1):L893-L900, 1998 Abstract | Full-Text (PDF) (8 pp, 149 K) | PubMed
Denning GM, Wollenweber LA, Railsback MA, Cox CD, Stoll LL, Britigan BE. Pseudomonas Pyocyanin Increases Interleukin-8 Release by Human Airway Epithelial Cells. Infection and Immunity, 66(12):5777-5784, 1998. Abstract | Full-Text (PDF) (8 pp, 660 K) | PubMed
Doerschug KC, Peterson MW, Dayton C, Kline JN. Asthma guidelines: an assessment of physician understanding and practice. American Journal of Respiratory and Critical Care Medicine, 159(6):1735-1741, 1999. Abstract | Full-Text (PDF) (7 pp, 179 K) | PubMed
Donham KJ, Cumro D, Reynolds SJ, Merchant JA. Dose-response relationships between occupational aerosol exposures and cross-shift declines of lung function in poultry workers: recommendations for exposure limits. Journal of Occupational and Environmental Medicine , 42(3):260-269, 2000. Abstract | PubMed
Duchaine C, Thorne PS, Meriaux A, Grimard Y, Whitten P, Cormien Y. Comparison of endotoxin exposure assessment by bioaerosol impinger and filter sampling methods. Applied and Environmental Microbiology, 67(6):2775-2780, 2001. Abstract | Full-Text (PDF) (6 pp, 80 K) | PubMed
Flaherty, D.M., Monick, M.M., Carter, A.B., Peterson, M. W. and Hunninghake, G.W. GM-CSF Increases AP-1 DNA-Binding and REF-1 Amounts in Human Alveolar Macrophages. American Journal of Respiratory Cell and Molecular Biology, 25(2):254-259, 2001. Abstract | Full-Text (PDF) (6 pp, 130 K) | PubMed
George CL, Jin H, Wohlford-Lenane CL, O'Neill ME, Phipps JC, O'Shaughnessy P, Kline JN, Thorne PS, Schwartz DA. Endotoxin responsiveness and subchronic grain dust-induced airway disease. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2001 Feb;280(2):L203-L213. Abstract | Full-Text (PDF) (11 pp, 2.8 MB) | PubMed
George CLS, White M, O'Neill M, Thorne PS, Schwartz DA, Snyder J. Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2003; 285(6): L1337-1344. Abstract | Full-Text (PDF) (9 pp, 466 K) | PubMed
George CS, Schwartz DA: The role of endotoxin in acute and chronic grain dust induced airway disease. Relationships Between Acute and Chronic Effects of Air Pollution, edited by U. Mohr et al. Washington, ILSI Press, 2000, p. 169-184.
Gudmundsson G., Hunninghake G.W. Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice. American Journal of Respiratory Cell and Molecular Biology, 19(5):812-8, 1998. Abstract | Full-Text (PDF) (7 pp, 238 K) | PubMed
Gudmundsson G., Hunninghake G.W. Respiratory epithelial cells release interleukin-8 in response to a thermophilic bacteria that causes hypersensitivity pneumonitis. Experimental Lung Research, 25:217-228, 1999.
Gudmundsson G., Monick M., Hunninghake G.W. Viral infection modulates expression of hypersensitive pneumonitis. The Journal of Immunology, 162:7397-7401, 1999.
GudmundssonG., Monick M.M., Hunninghake G.W. Interleukin-12 modulates expression of hypersensitivity pneumonitis. The Journal of Immunology, 161(2):991-999, 1998. Abstract | Full-Text (PDF) (9 pp, 302 K) | PubMed
Heederik D, Thorne PS, Doekes G. Health-based recommended exposure limits for allergens: how far do we have to go? The Annals of Occupational Hygiene, 46(5):439-446, 2002.
Hollingsworth II, JW, Cook, DN, Brass, DM, Walker, JKL, Morgan, DL, Foster, WM, Schwartz, DA. The role of Toll-like receptor 4 in environmental airway injury in mice. American Journal of Respiratory and Critical Care Medicine, 170(2):126-132, 2004. Abstract | Full-Text (PDF) (7 pp, 116 K) | PubMed
Jagielo PJ, Quinn TJ, Qureshi N, Schwartz DA. Grain dust induced lung inflammation is reduced by Rhodobacter referred diphosporyl lipid A. American Journal of Physiology: Lung Cellular and Molecular Physiology, 1998; 274:L26-L31.
Johnston S.L., Mastronarde J.G., Monick M.M., Hunninghake G.W. Low grade rhinovirus infection induces a prolonged release of IL-8 in pulmonary epithelium. The Journal of Immunology, 160(12):6172-6181, 1998. Abstract | Full-Text (PDF) (10 pp, 247 K) | PubMed
Jones ML, Reynolds SJ, Burmeister LF, Lewis MQ, Whitten PS, Scarth RD, and Zwerling C. Application of a subjective health and safety rating system to Iowa farm operations. Applied Occupational and Environmental Hygiene, 14(12):852-867, 1999. Abstract | PubMed
Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. The New England Journal of Medicine, 2002; 347(3):185-192. Abstract | PubMed
Kirychuk S, Donham K, Reynolds S, Burmeister L, Barber E, Thorne P, Senthilselvan A, Rautiainen R. Oil/water sprinkling intervention in a swine building. Proceedings of the International Symposium on Dust Control in Animal Production Facilities, Aarhus, Denmark, 335-342, May 30-Jun 2; 1999.
Kline JN, Cowden JD, Hunninghake GW, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA. Variable airway responsiveness to inhaled lipopolysaccharide. American Journal of Respiratory and Critical Care Medicine, 1999; 160(1):297-303. Abstract | Full-Text (PDF) (7 pp, 184 K) | PubMed
Kline JN, Jagielo PJ, Watt JL, Schwartz DA. Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. Journal of Applied Physiology, 2000; 89(3): 1172-1178. Abstract | Full-Text (PDF) (8 pp, 240 K) | PubMed
Kline JN, Kitagaki K, Businga TR, Jain VV. Treatment of established asthma in a murine model using CpG oligodeoxynucleotides. American Journal of Physiology: Lung Cellular and Molecular Physiology, 283(1):L170-L179, 2002. Abstract | Full-Text (PDF) (10 pp, 348 K) | PubMed
Kline J.N., Hunninghake G.M., He B., Monick M.M., Hunninghake G.W. Synergistic Activation of the Human Cytomegalovirus Major Immediate Early Promotor by Prostaglandin E2 and Cytokines. Experimental Lung Research, 24(1):3-14, 1998. Abstract | PubMed
Kline J.N., Krieg A.M., Waldschmidt T.J., Ballas Z.K., Jain V, Businga T.R. CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma. Journal of Allergy & Clinical Immunology, 104:1258-64, 1999.
Kline J.N., Waldschmidt T.A., Businga T.R., Lemish J.E., Weinstock J.V., Thorne P.S., Krieg A.M. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. The Journal of Immunology, 160(6):2555-2559, 1998. Abstract | Full-Text (PDF) (5 pp, 324 K) | PubMed
Kline J.N., Cowden J.D., Hunninghake G.W., Watt J.L., Schwartz D.A. Expression of sensitive or hyporesponsive phenotypes in individuals challenged with inhaled lipopolysaccharide. American Journal of Respiratory and Critical Care Medicine, 160:297-303, 1999.
Kullman GJ, Thorne PS, Waldron PF, Marx JJ, Ault B, Lewis DM, Siegel PD, Olenchock SA, Merchant JA. Organic dust exposures from work in dairy barns. American Industrial Hygiene Association Journal, 59(6):403-413, 1998. Abstract | PubMed
Leidal KG, Munson K, Johnson M, Denning GM. Small molecular weight secretory factors from Pseudomonas aeruginosa have opposite effects on IL-8 and RANTES expression by human airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 25(2):186-195, 2001. Abstract | Full-Text (PDF) (10 pp, 143 K) | PubMed
Lewis MQ, Sprince NL, Burmeister LF, Whitten PS, Torner JC, and Zwerling C. Work-related injuries among Iowa farm operators: An analysis of the Iowa Farm Family Health and Hazards Surveillance Project. American Journal of Industrial Medicine, 33:510-517, 1998.
Lorenz E, Frees KL, Schwartz DA. Determination of the TLR4 genotype using allele-specific PCR. Biotechniques, 2001; 31(1):22-24.
Lorenz E, Hallman M, Marttila R, Haataja R, Schwartz DA. Association between alleles in the toll-like receptor 4 gene and premature births in the Finnish population. Pediatric Research, 2002; 52:373-376.
Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA. Genes other than TLR4 are involved in the response to inhaled LPS. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2001; 281(5):L1106-1114. Abstract | Full-Text (PDF) (9 pp, 173 K) | PubMed
Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the Toll-like receptor 2 gene and its potential association with staphylococcal infection. Infection and Immunity, 2000; 68(11): 6398-6401. Abstract | Full-Text (PDF) (4 pp, 70 K) | PubMed
Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Archives of Internal Medicine, 2002; 162(21): 1028-1032. Abstract | PubMed
Lorenz E, Patel DD, Hartung T, Schwartz DA. Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipoppolysaccharide. Infection and Immunity, 2002; 70:4892-4896.
Lorenz E, Schwartz DA, Martin PJ, Gooley T, Lin MT, Chien JW, Hansen JA, Clark JG. Association of TLR-4 mutations and the risk for acute GVHD after HLA-matched sibling hematopoietic stem cell transplantation. Biology of Blood & Marrow Transplantation, 2001; 7(7): 384-387. Abstract | PubMed
Mahar S, Reynolds SJ, Thorne PS. Worker exposures to particulates, endotoxins, and bioaerosols in two refuse-derived fuel plants. American Industrial Hygiene Association Journal, 60(5): 679-683, 1999. Abstract | PubMed
Mastronarde J.G., Monick M.M., Mukaida N., Matsushima K., Hunninghake G.W. Activator protein (AP)-1 is the referred transcription factor for cooperative interaction with nuclear factor (NF)- kB in respiratory syncytial virus-induced interleukin (IL)-8 gene expression in airway epithelium. The Journal of Infectious Diseases, 177 :1275-8, 1998.
McCormick ML, Denning GM, Reszka KJ, Bilski P, Buettner GR, Rasmussen GT, Railsback MA., Britigan BE. Biological effects of menadione photochemistry: Effects of menadione on biological systems may not involve classical oxidant production. Biochemical Journal, 350: 797-804, 2000.
McCray PB, Zabner J, Jia HP, Welsh MJ, Thorne PS. Efficient killing of inhaled bacteria in ?F508 mice: role of airway surface liquid composition. American Journal of Physiology: Lung Cellular and Molecular Physiology, 21: L183-L190, 1999.
McGowan SE, Smith J, Holmes AJ, Smith LA, Madsen MT, Businga TR, Kopp U, Kline JN. Vitamin A deficiency promotes bronchial hyperreactivity in rats by altering muscarinic-2 receptor function. American Journal of Physiology: Lung Cellular and Molecular Physiology, 285(5);L1031-1039, 2002.
Moreland J.G., Bailey G, Nauseef W.M., Weiss J.P. Organism-Specific Neutrophil-Endothelial Cell Interactions in Response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. The Journal of Immunology, Jan 2004; 172(1): 426-432. Abstract | Full-Text (PDF) (7 pp, 192 K) | PubMed
Monick, M., Carter, A.B., and Hunninghake, G.W. Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity. Journal of Biological Chemistry, 274(25):18075-18080, 1999. Abstract | Full-Text (PDF) (6 pp, 315 K) | PubMed
Monick M.D., Carter A.B., Robeff P.K., Flaherty D.M., Peterson M.W., Hunninghake G.W. Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of b -catenin. The Journal of Immunology, 166:4713-4720, 2001.
Monick M.M., Carter A.B., Flaherty D.W., Peterson M.W., Hunninghake G.W. PKC z plays a central role in activation of the p42/44 MAP kinase by endotoxin in alveolar macrophages. The Journal of Immunology, 165:4632-4639, 2000.
Monick M.M., Carter A.B., Gudmundsson G., Geist L.J., Hunninghake G.W. Changes in PKC isoforms and phorbol ester-induced mitogen activated protein kinase activity in human alveolar macrophages compared to blood monocytes. American Journal of Physiology: Lung Cellular and Molecular Physiology, 275:L389-L397, 1998.
Monick M.M., Carter A.B., Gudmundsson G., Mallampalli R., Powers LS., Hunninghake G.W. A phosphatidylcholine-specific phospholipase C (PC-PLC) regulates activation of p42/44 MAP kinases in LPS-stimulated human alveolar macrophages. The Journal of Immunology, 162:3005-3012, 1999.
Monick M.M., Mallampalli R.K., Carter A.B., Flaherty D., McCoy D., Robeff P., Peterson M.W., Hunninghake G.W. Ceramide regulates lipopolysaccharide-induced phosphatidylinositol 3-kinase and Akt activity in human alveolar macrophages. The Journal of Immunology, 167(10):5977-5985, 2001. Abstract | Full-Text (PDF) (9 pp, 333 K) | PubMed
Monick M.M., Powers L.S., Butler N.S., Hunninghake G.W. Inhibition of Rho family GTPases results in increased TNF-α production after lipopolysaccharide exposure. The Journal of Immunology, 171(5):2625-2630, 2003. Abstract | Full-Text (PDF) (6 pp, 303 K) | PubMed
Monick M.M., Robeff P.K., Butler N.S., Flaherty D.M., Carter A.B., Peterson M.W., Hunninghake, G.W. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. Journal of Biological Chemistry, 277(36): 32992-33000, 2002. Abstract | Full-Text (PDF) (9 pp, 638 K) | PubMed
Monick M.M., Staber J.M., Hunninghake G.W. Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. The Journal of Immunology, 166(4):2681-2687, 2001. Abstract | Full-Text (PDF) (7 pp, 1.8 MB) | PubMed
Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA. CD11b and ICAM-1 are essential to pulmonary neutrophil recruitment in LPS-induced airway disease. American Journal of Respiratory Cell and Molecular Biology, 2002; 27(4): 474-480.
Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA. TNF- a and IL-1 b are not essential to the inflammatory response in LPS induced airway disease. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2001; 280(1):L173-L180.
Nonnenmann MW, Rautiainen RH, Donham KJ, Kirychuk SP, Reynolds SJ, O'Shaughnessy PT, Thorne PS. Vegetable oil sprinkling as a dust reduction method in a swine confinement. Proceedings of the International Symposium on Dust Control in Animal Production Facilities, Aarhus, Denmark, 271-278, May 30-Jun 2, 1999.
Nyunoya T., Powers L.S. Yarovinsky T.O., Butler N.S., Monick M.M., Hunninghake G.W. Hyperoxia Induces Macrophage Cell Cycle Arrest by Adhesion-dependent Induction of p21 Cip1 and Activation of the Retinoblastoma Protein. Journal of Biological Chemistry, 278(38):36099-36106, 2003.
Park HS, Reynolds SJ, Kelly KM, Stromquist AM, Burmeister LF, Zwerling C, Merchant JA. Characterization of Agricultural Tasks Performed by Youth in the Keokuk County Rural Health Study. Journal of Occupational and Environmental Hygiene, 18(6):418-429, 2003. Abstract | PubMed
Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA. IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. Journal of Applied Physiology, 2000; 88(1): 173-179. Abstract | Full-Text (PDF) (8 pp, 183 K) | PubMed
Reynolds SJ, Black DW, Borin S, Breuer G, Burmeister LF, Fuortes LJ, Smith TF, Stein M, Subramanian P, Thorne PS, Whitten P. Indoor environmental quality in six commercial office buildings in the Midwest U.S. American Industrial Hygiene Association Journal, (submitted Nov. 2000).
Reynolds SJ, Black DW, Breuer G, Burmeister LF, Fuortes LJ, Smith TF, Stein M, Subramanian P, Thorne PS, Whitten P. Indoor Environmental Quality in Large Office Buildings in the Midwest US. In AWMA Journal special issue - Measurement of Toxic and Related Air Pollutants, Dec 1998.
Reynolds SJ, Chao DY, Thorne PS, Subramanian P, Waldron PF, Selim M, Whitten PS, Popendorf WJ. Field comparison of methods for evaluation of vapor/particle phase distribution of ammonia in livestock buildings. JASH 4(2):81-93, 1998.
Reynolds SJ, Merchant JA, Stromquist AM, Burmeister LF, Taylor C, Lewis MQ, and Kelly KM. Keokuk County Iowa Rural Health Study: Self-reported use of pesticides and protective equipment. Journal of Agricultural Safety and Health Special Issue (1):67-77, 1998.
Reynolds SJ, Thorne PS, Donham KJ, Croteau EA, Kelly KM, Lewis D, Whitmer M, Heederik DJ, Douwes J, Connaughton I, Koch S, Malmberg P, Larsson BM, Milton DK. Comparison of Endotoxin Assays Using Agricultural Dusts. American Industrial Hygiene Association Journal, 63(4):430-438, 2002. Abstract | PubMed
Sprince NL, Lewis MQ, Whitten PS, Reynolds SJ, Zwerling C. Respiratory symptoms: Associations with pesticides, silos, and animal confinement in the Iowa Farm Family Health and Hazard Surveillance Project. American Journal of Industrial Medicine 38(4): 455-462, 2000. Abstract | PubMed
Sanlioglu, S., Williams, C.M., Samavati, L., Butler, N.S., Wang, G., McCray Jr., P.B., Ritchie, T.C., Hunninghake, G.W., Zandi, E., and Engelhardt, J.F. LPS Induces Rac1-Dependent Reactive Oxygen Species (ROS) Formation and Coordinates TNF-a Secretion Through IKK Regulation of NF-κ B. Journal of Biological Chemistry, 276(32):30188-30198, 2001.
Savov JD, Brass DM, Berman KG, McElvania E, Schwartz DA. Fibrinolysis in LPS induced chronic airway disease. American Journal of Physiology: Lung Cellular and Molecular Physiology, 285(4):L940-L948, 2003. Abstract | Full-Text (PDF) (10 pp, 928 K) | PubMed
Savov J.D., Gavett S.H., Brass D.M., Costa D.L., Schwartz D.A. Neutrophils play a critical role in the development of LPS-induced airway disease. American Journal of Physiology: Lung Cellular and Molecular Physiology, 283(5): L952-L962, 2002. Abstract | Full-Text (PDF) (11 pp, 863 K) | PubMed
Savov JD, Whitehead GS, Wang J, Liao G, Usuka J, Peltz G, Foster WM, Schwartz DA. Ozone-induced acute pulmonary injury in inbred mouse strains. American Journal of Respiratory Cell and Molecular Biology, 31(1):69-77, 2004. Abstract | Full-Text (PDF) (9 pp, 379 K) | PubMed
Scarth RD, Rohrer JE, Burmeister LF, and Zwerling C. Perceptions of access to medical care among Iowa farmers. Journal of Agromedicine, 5(4):5-20, 1998.
Schromm AB, Lien E, Henneke P, Chow JC, Yoshimura A, Heine H, Latz E, Monks BG, Schwartz DA, Miyake K, Golenbock DT. Molecular genetic analysis of an endotoxin non-responder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. The Journal of Experimental Medicine, 2001; 194:79-88.
Schwartz DA, and the Committee of the Assembly on Environmental and Occupational Health. American Thoracic Society: Respiratory Health Hazards in Agriculture. American Journal of Respiratory and Critical Care Medicine, 1998; 158:S1-S76.
Schwartz DA, Christ WJ, Wohlford-Lenane CL. Inhibition of LPS induced airway hyperresponsiveness and airway inflammation by LPS antagonists. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2001; 280(4): L771-L778. Abstract | Full-Text (PDF) (9 pp, 418 K) | PubMed
Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize LPS-induced inflammation in the lower respiratory tract through an IL-12 dependent pathway. The Journal of Immunology, 1999; 163:224-231.
Schwartz DA. Does inhalation of endotoxin cause asthma? American Journal of Respiratory and Critical Care Medicine 2001; 163(2): 305-306. Full-Text (PDF) (2 pp, 160 K)
Schwartz DA. Inhaled endotoxin, a risk for airway disease in some people. Respiration Physiology 2001; 128(1):47-55. Abstract | PubMed
Schwartz DA. Etiology and pathogenesis of airway disease in children and adults from rural communities. Environmental Health Perspectives, 1999; 107 (Suppl 3):393-401. Abstract | PubMed
Schwartz DA. The role of TLR4 in endotoxin responsiveness in humans. Journal of Endotoxin Research, 2001; 7(5):389-393.
Skorska C, Mackiewicz B, Dutkiewicz J, Krysinska-Traczyk E, Milanowski J, Feltovich H, Lange J, Thorne PS. Effects of exposure to grain dust in Polish farmers: work-related symptoms and immunologic response to microbial antigens associated with dust. Annals of Agricultural and Environmental Medicine, 5(2):147-153, 1998. Abstract | PubMed
Sly L.M., Lopez M., Nauseef W.M., Reiner N.E. la,25-Dihydroxyvitamin D3-induced Monocyte Antimycobacterial activity Is Regulated by Phosphatidylinositol 3-Kinase and Mediated by the NADPH-dependent Phagocyte Oxidase. Journal of Biological Chemistry, 276(38):35482-35493, 2001.
Taylor CD, Reynolds SJ, Stromquist A, Merchant J, Zwerling C, Kelly K. Environmental conditions in the homes of a rural Iowa county. JASH 5:407-416, 1999.
Taylor CD, Reynolds SJ. Comparison of a direct-reading device to gravimetric methods for evaluating organic dust aerosols in enclosed swine production buildings. American Industrial Hygiene Association Journal, 16(1) :78-83, 2001
Thomas K.W., Monick M.M., Staber J.M., Yarovinsky T.O., Carter A.B., Hunninghake G.W. Respiratory syncytial virus inhibits apoptosis and induces NF-κ B activity through a phosphatidylinositol 3-kinase-dependent pathway. Journal of Biological Chemistry 277(1):492-501, 2002. Abstract | Full-Text (PDF) (10 pp, 518 K) | PubMed
Thorne PS, McCray PB, Howe TS, O'Neill MA. Early-onset inflammatory responses in vivo to adenoviral vectors in the presence or absence of LPS-induced inflammation. American Journal of Respiratory Cell and Molecular Biology, 20(6):1155-1164, 1998.
Thorne PS. Inhalation toxicology models of endotoxin and bioaerosol-induced inflammation. Toxicology, 152:13-23; 2000.
Trapp JF, Watt JL, Frees KL, Quinn TJ, Nonneman MW, Schwartz DA. The effect of glucocorticoids on grain dust induced airway disease. Chest, 1998; 113(2):505-513. Abstract | Full-Text (PDF) (11 pp, 724 K) | PubMed
Walker JKL, Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ. b-arrestin-2 regulates the development of allergic asthma. The Journal of Clinical Investigation, 112:566-574, 2003.
Warshamana GS, Pociask DA, Sime P, Schwartz, DA, Brody AR. Susceptibility to asbestos-induced and TGF-β 1-induced fibroproliferative lung disease in two strains of mice. American Journal of Respiratory Cell and Molecular Biology, 2002: 27:705-713.
Whitehead GS, Walker JKL, Berman KG, Foster WM, Schwartz DA. Allergen induced airway disease is mouse strain dependent. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2003; 285(1):L32-42. Abstract | Full-Text (PDF) (11 pp, 212 K) | PubMed
Wohlford-Lenane CL, Deetz DC, Schwartz DA. Cytokine gene expression following inhalation of corn dust. American Journal of Physiology: Lung Cellular and Molecular Physiology, 1999; 276:L736-L743.
Wouters I, Thorne PS, Heederik D, Doekes G. Reproducibility of induced cytokine responsiveness in a whole blood assay. Submitted 2001.
Wouters IM, Douwes J, Doekes G, Thorne PS, Heederik DJJ. Increased levels of markers of microbial exposure in homes with indoor storage of organic household waste. Applied and Environmental Microbiology, 66(2):627-631, 2000. Abstract | Full-Text (PDF) (5 pp, 120 K) | PubMed
Zeldin DC, Wohlford-Lenane C, Chulada P, Bradbury JA, Scarborough PE, Roggli V, Langenbach R, Schwartz DA. Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. American Journal of Respiratory Cell and Molecular Biology, 2001; 25(4):457-465. Abstract | Full-Text (PDF) (9 pp, 245 K) | PubMed
Zwerling C, Burmeister L, Reynolds S, Jones M, Lewis M, Popendorf W, Scarth R, Whitten P. The Iowa Farm Family Health and Hazard Surveillance Project. Journal of Agricultural Safety and Health, Special Issue (1):13-20, 1998.
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