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Extramural Research

2013 Level III Scientific and Technological Achievement Awards (STAA) Awarded Nominations

Grantee Research Project Results

Extramural Research Search

2013 STAA Awards

The 2013 STAA Awards are Now Available:
Level I | Level II | Level III | Honorable Mentions

Level III awards - are for those who have accomplished an unusually notable research or technological effort. The awards are for a substantial revision or modification of a scientific/technological principle or procedure, or an important improvement to the value of a device, activity, program, or service to the public. Awarded research relates to a mission or organizational component of the EPA, or significantly affects a relevant area of science/technology.

Scientist at work  Bumblebee ORD Research Vessel  Field sampling

Nominations Recommended for a Level III Award -- Total of Twenty-Eight
Nom. ID Publication Title & Full Citation Eligible/Ineligible Authors Lab/Office/Institution Citation
S13ER0008 (1) Metabolite Profiling and a Transcriptional Activation Assay Provide Direct Evidence of Androgen Receptor Antagonism by Bisphenol A in Fish

Environmental Science & Technology, 46:9673-9680 (2012)

(2) Use of Chemical Mixtures to Differentiate Mechanisms of Endocrine Action in a Small Fish Model

Aquatic Toxicology, 99:389-396 (2010)

Gerald T. Ankley

Drew R. Ekman

Elizabeth J. Durhan

Kathleen M. Jensen

Michael D. Kahl

Daniel L. Villeneuve

Mary C. Cardon

David M. Skelton

Timothy W. Collette

L. Earl Gray, Jr.

Phillip C. Hartig

Elizabeth A. Makynen

Quincy Teng

Jenna E. Cavallin (Non-EPA)

Nathan D. Mueller (Non-EPA)

Leah C. Wehmas (Non-EPA)

Dalma Martinovic (Non-EPA)

NHEERL, Duluth, MN Innovative Use of Multiple Lines of Evidence to Establish an Anti-Androgenic Mode of Action for Bisphenol A in Fish
S13ER0011 (1) Structural and Functional Characteristics of Natural and Constructed Headwater Channels Draining a Reclaimed Mountaintop Removal and Valley Fill Coal Mine

Journal of the North American Benthological Society, 29(2):673-689 (2010)

(2) An Assessment of Cellulose Filters as a Standardized Material for Measuring Litter Breakdown in Headwater Streams

Ecohydrology, 4(3):469-476 (2011)

Ken M. Fritz

Stephanie Fulton

Brent R. Johnson

Roger A. Burke

Christopher D. Barton (Non-EPA)

Jeffrey D. Jack (Non-EPA)

David A. Word (Non-EPA)

NERL, Cincinnati, OH Providing Science to Inform Decisions on Compensatory Mitigation of Headwater Streams Affected by Surface Mining
S13ER0014 Watershed and Lake Influences on the Energetic Base of Coastal Wetland Food Webs Across the Great Lakes Basin

Journal of Great Lakes Research, 38(3):418-428 (2012)

Michael E. Sierszen

John C. Brazner

Anne M. Cotter

John A. Morrice

Gregory S. Peterson

Anett S. Trebitz

NHEERL, Duluth, MN Identifying Ecosystem Interactions that Support Great Lakes Coastal Food Webs
S13HE0017 (1) Evaluation of Two Different Metabolic Hypotheses for Dichloromethane Toxicity Using Physiologically Based Pharmacokinetic Modeling for In Vivo Inhalation Gas Uptake Exposure in Female B6C3F1 Mice

Toxicology and Applied Pharmacology, 244(3):280-290 (2010)

(2) Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats

Journal of Toxicology, 2012(629781):1-14 (2012)

Marina V. Evans

Jane C. Caldwell

Christopher R. Eklund

William S. Cuello (Non-EPA)

Tyler A. Janes (Non-EPA)

Jill M. Jessee (Non-EPA)

Melissa A. Venecek (Non-EPA)

Megan E. Sawyer (Non-EPA)

NHEERL, Research Triangle Park, NC Testing of a Mechanistic Hypothesis for Volatile Methanes Using Computational Modeling and Sensitivity Analyses
S13HE0018 Relative Bioavailability and Bioaccessibility and Speciation of Arsenic in Contaminated Soils

Environmental Health Perspectives/Peer-reviewed, 119(11):1629-1634 (2011)

Karen D. Bradham

Kirk G. Scheckel

David J. Thomas

Clay M. Nelson

Michael F. Huges

Aaron Yeow

Sophia M. Serda

Sharon Harper

Paul E. Seales (Non-EPA)

Grace E. Lee (Non-EPA)

Bradley W. Miller (Non-EPA)

Thomas Gilmore (Non-EPA)

NRMRL, Cincinnati, OH Assessing and Predicting the Risk of Soil Arsenic on Human Health
S13HE0021 (1) Short-term Exposure to Triclosan Decreases Thyroxine in Vivo via Upregulation of Hepatic Catabolism

Toxicological Sciences, 113(2):367-379 (2010)

(2) Developmental Triclosan Exposure Decreases Maternal and Neonatal Thyroxine in Rats

Environmental Toxicology and Chemistry, 29(12):2840-2844 (2010)

(3) Developmental Triclosan Exposure Decreases Maternal, Fetal, and Early Neonatal Thyroxine: A Dynamic and Kinetic Evaluation of a Putative Mode-of-Action

Toxicology, 300(1-2):31-45 (2012)

Kevin M. Crofton

Joan M. Hedge

Michael J. DeVito

Katie B. Paul (Non-EPA)

Ruby Bansal (Non-EPA)

Robert Peter (Non-EPA)

R. Thomas Zoeller (Non-EPA)

NHEERL, Research Triangle Park, NC Characterization of an Adverse Outcome Pathway for the Thyroid-Disrupting Activity of Triclosan across Life-Stages
S13HE0024 The Exposure Data Landscape for Manufactured Chemicals

Science of the Total Environment, 414:159-166 (2012)

Peter P. Egeghy

Elaine A. Cohen Hubal

Richard Judson

Sumit Gangwal

Shad Mosher (Non-EPA)

Doris Smith (Non-EPA)

James Vail (Non-EPA)

NERL, Research Triangle Park, NC Revealing the Paucity of Readily Accessible Human-Exposure Data on the Vast Majority of Chemicals in Commerce
S13HE0027 Approaches to Cancer Assessment in EPA's Integrated Risk Information System

Toxicology and Applied Pharmacology, 254(2):170-180 (2011)

Martin W. Gehlhaus, III

Jeff Gift

Karen Hogan

Leonid Kopylev

Paul Schlosser

Abdel Kadry

NCEA, Washington, DC Contributions to the Improved Transparency of Carcinogen Risk Assessment within IRIS Human-Health Assessments
S13HE0032 (1) Subchronic Pulmonary Pathology, Iron Overload, and Transcriptional Activity after Libby Amphibole Exposure in Rat Models of Cardiovascular Disease

Environmental Health Perspectives, 120(1):85-91 (2012)

(2) The role of iron Libby amphibole-induced acute lung injury and inflammation

Inhalation Toxicology, 23(6):313-323 (2011)

(3) Transcriptional activation of inflammasome components by Libby amphibole and the role of iron

Inhalation Toxicology, 24(1):60-69 (2012)

Urmila P. Kodavanti

Matte C. Schladweiler

Stephen H. Gavett

Andrew J. Ghio

Beena D. Vallanat

William O. Ward

John K. McGee

Debora Andrews

Judy E. Richards

Jonathan H. Shannahan (Non-EPA)

Mark Cesta (Non-EPA)

Abraham Nyska (Non-EPA)

NHEERL, Research Triangle Park, NC Unraveling the Role of Iron in Asbestos Toxicity and Susceptibility of Those with Disease-Related Iron Overload
S13HE0033 (1) Application of WWTP Biosolids and Resulting Perfluorinated Compound Contamination in Surface and Well Water in Decatur, Alabama, USA

Environmental Science & Technology, 45(19):8015-8021 (2011)

(2) Determination of Perfluorinated Compounds in the Upper Mississippi River Basin

Environmental Science & Technology, 44(11):4103-4109 (2010)

(3) Geographical Distribution of Perfluorinated Compounds in Fish From Minnesota Lakes and Rivers

Environmental Science & Technology, 44(7):2549-2554 (2010)

Andrew B. Lindstrom

Mark J. Strynar

E. Laurence Libelo

Michael Neill

Amy D. Delinsky (Non-EPA)

Shoji F. Nakayama (Non-EPA)

Larry McMillan (Non-EPA)

Jerry Varns (Non-EPA)

Patricia McCann (Non-EPA)

Jessica Reiner (Non-EPA)

NERL, Research Triangle Park, NC Research Characterizing the Transport and Fate of Persistent Perfluorinated Compounds in the Environment
S13HE0040 (1) An Integrated Imaging Approach to the Study of Oxidative Stress Generation by Mitochondrial Dysfunction in Living Cells

Environmental Health Perspectives, 118(7):902-908 (2010)

(2) Linking Oxidative Events to Inflammatory and Adaptive Gene Expression Induced by Exposure to an Organic Particulate Matter Component

Environmental Health Perspectives, 120(2):267-264 (2112)

(3) Monitoring Intracellular Redox Changes in Ozone-Exposed Airway Epithelial Cells

Environmental Health Perspectives, : (2012)

James M. Samet

Steven O. Simmons

Robert M. Zucker

Robert Silbajoris

Haiyan Tong

Wan-Yun Cheng (Non-EPA)

Eugene Gibbs-Flournoy (Non-EPA)

Philip Bromberg (Non-EPA)

Thomas Hofer (Non-EPA)

Evan W. Miller (Non-EPA)

Christopher Chang (Non-EPA)

James Remington (Non-EPA)

Tobias P. Dick (Non-EPA)

Jenna Currier (Non-EPA)

NHEERL, Research Triangle Park, NC Implementation of an Advanced Molecular-Imaging Approach to the Study of Environmental Oxidant Stress
S13HE0041 (1) Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles

BMC Systems Biology, 5(109): (2011)

(2) Simulating Microdosimetry in a Virtual Hepatic Lobule

PLoS Computational Biology, 6(4):e1000756 (2010)

(3) Virtual Tissues in Toxicology

Journal of Toxicology and Environmental Health B Crit Rev, 13:314-328 (2010)

Imran Shah

John F. Wambaugh

John Jack

NCCT, Research Triangle Park, NC Innovations Allowing the Creation of Virtual Liver Tissues for Predicting In Vivo Effects From In Vitro Data
S13HE0043 Benchmark Dose Analysis for Bacillus anthracis Inhalation Exposures in the Nonhuman Primate

Risk Analysis, An International Journal, 32(10):1750-1768 (2012)

Sarah C. Taft

Stephanie A. Hines (Non-EPA)

NHSRC, Cincinnati, OH Benchmark Dose Analysis for Bacillus Anthracis to Inform Clearance Goals
S13HE0044 Evaluation of Deltamethrin Kinetics and Dosimetry in the Maturing Rat using a PBPK Model

Toxicology and Applied Pharmacology, 244(2):208-217 (2010)

Rogelio Tornero-Velez

Ahmad Mirfazaelian (Non-EPA)

Jeffrey W. Fisher (Non-EPA)

James V. Bruckner (Non-EPA)

Kyu-Bong Kim (Non-EPA)

Sathanandam S. Anand (Non-EPA)

Hyo J. Kim (Non-EPA)

Wendy T. Haines (Non-EPA)

NERL, Research Triangle Park, NC Accounting for Age Dependence in Pyrethroid Pharmacokinetics
S13IE0050 Near-Real-Time Combustion Monitoring for PCDD/PCDF Indicators by GC-REMPI-TOFMS

Environmental Science & Technology (Sci. Journal), 46(2):923-928 (2012)

Lukas Oudejans

Brian Gullett

Dennis Tabor

Shawn Ryan

Abderrahmane Touati (Non-EPA)

NRMRL, Cincinnati, OH Advancing State-of-the-Art Technology to Measure Diox/Furan Emmissions from Combustion Sources in Near Time
S13IR0054 Direct Application of Biota-Sediment Accumulation Factors

Environmental Toxicology and Chemistry, 29(1):230-236 (2010)

Lawrence P. Burkhard

Philip M. Cook

Marta T. Lukasewycz

NHEERL, Duluth, MN Understanding the Uncertainties in Applying Biota-Sediment Accumulation Factors at Superfund Sites
S13MM0056 Development and Evaluation of EPA Method 1615 for Detection of Enterovirus and Norovirus in Water Applied and Environmental Microbiology, 79(1):215-223

Applied and Environmental Microbiology, 79(1):215-223 (2013)

Jennifer L. Cashdollar

Nichole E. Brinkman

Shannon M. Griffin

Brian R. McMinn

Eric R. Rhodes

Eunice A. Varughese

G. Shay Fout

Ann C. Grimm

Sandhya U. Parshionikar

Larry Wymer

NERL, Cincinnati, OH Development and Evaluation of EPA Method 1615
S13MM0059 (1) Metagenome Analyses of Corroded Concrete Wastewater Pipe Biofilms Reveal a Complex Microbial System

BioMed Central Microbiology, 12(122):1-14 (2012)

(2) Metagenomic Analyses of Drinking Water Receiving Different Disinfection Treatments

Applied and Environmental Microbiology, 78(17):6095-6102 (2012)

Jorge W. Santo Domingo

Randy P. Revetta

Vicente Gomez-Alvarez

NRMRL, Cincinnati, OH Characterization of Microbial Functional Networks of Drinking Water and Wastewater Systems via Metagenome Analysis
S13OR0063 Effects from Filtration, Capping Agents, and Presence/Absence of Food on the Toxicity of Silver Nanoparticles to Daphnia magna

Environmental Toxicology and Chemistry, 29(12):2742-2750 (2010)

H. Joel Allen

Christopher A. Impellitteri

Dana A. Macke

Deborah L. Roose

Helen C. Poynton

James M. Lazorchak

J. Lee Heckman (Non-EPA)

Shekar Govindaswamy (Non-EPA)

Mallikarjuna N. Nadagouda (Non-EPA)

NRMRL, Cincinnati, OH Research Regarding the Toxicity of Silver Nanoparticles
S13OR0065 Post-processing Method to Reduce Noise while Preserving High Time Resolution in Aethalometer Real-time Black Carbon Data

Aerosol and Air Quality Research (Scientific Journal, 11:539-546 (2011)

Gayle S.W. Hagler

Tiffany L.B. Yelverton

Ram Vedantham

Anthony D.A. Hansen (Non-EPA)

Jay R. Turner (Non-EPA)

NRMRL, Cincinnati, OH A Noise-Reduction Algorithm to Improve the Utility of Black-Carbon Data - a Key Pollutant of Concern for Health and Climate
S13OR0069 Human and Rat ABC Transporter Efflux of Bisphenol A and Bisphenol A Glucuronide: Interspecies Comparison and Implications for Pharmacokinetic Assessment

Toxicological Sciences, 128(2):317-325 (2012)

Christopher S. Mazur

Satori Marchitti

John Kenneke

Mira Dimova (Non-EPA)

Annie Lumen (Non-EPA)

Jeff Fisher (Non-EPA)

NERL, Athens, GA Providing Critical Pharmacokinetic Data Needed for Human-Health Risk Assessment of BPA
S13OR0072 Production and Consumption of Reactive Oxygen Species by Fullerenes

Environmental Toxicology & Chemistry, 31(1):136-143 (2012)

Richard G. Zepp

Lingjun Kong (Non-EPA)

NERL, Athens, GA Creative Research on Data and Relationships for Evaluating Environmental Production of ROS by Carbon Nanoparticles
S13RA0077 Active Pharmaceutical Ingredients and Aquatic Organisms

Environmental Contaminants in Biota: Interpreting Tissue Concentrations, W. Nelson Beyer and James P. Meador (Eds.), 2nd, ch. 8:287-347 (2011)

Christian G. Daughton

Bryan W. Brooks (Non-EPA)

NERL, Las Vegas, NV First Synoptic Review of Aquatic Biota Exposure to Pharmaceutical Residues: Tissue Levels and Bioconcentration
S13RA0079 (1) U.S. Environmental Protection Agency Radiogenic Risk Models and Projections for the U.S. Population

Health Physics / Print, : (2012)

(2) U.S. Environmental Protection Agency Radiogenic Risk Projections: Uncertainty Analysis

Health Physics / Print, : (2012)

David J. Pawel

Jerome S. Puskin

ORIA, Washington, DC Outstanding Papers on EPA's Radiogenic Cancer Risk Projections and Their Uncertainties
S13SI0088 Green Pharmacy and Pharm Ecovigilance: Prescribing and the Planet

Expert Review of Clinical Pharmacology, 4(2):211-232 (2011)

Christian G. Daughton

Ilene S. Ruhoy (Non-EPA)

NERL, Las Vegas, NV Sustainable Solutions in Healthcare to Prevent Medication Waste and Environmental Contamination by Pharmaceuticals
S13SI0090 (1) Ecological Periodic Tables for Benthic Macrofaunal Usage of Estuarine Habitats in the US Pacific Northwest

Estuarine, Coastal and Shelf Science, 94:36-47 (2011)

(2) Ecological Periodic Table for Benthic Macrofaunal Usage of Estuarine Habits: Insights from a Case study in Tillamook Bay, Oregon, USA

Estuarine, Coastal and Shelf Science, 102-103:70-83 (2012)

Steven P. Ferraro

Faith A. Cole

NHEERL, Corvallis, OR Groundbreaking Research and Development on Ecological Periodic Tables
S13TF0096 (1) Incremental Testing of the Community Multiscale Air Quality (CMAQ) Modeling System Version 4.7

Geoscientific Model Development, 3(1):205-226 (2010)

(2) Model Representation of Secondary Organic Aerosol in CMAQv4.7

Environmental Science and Technology, 44(22):8553-8560 (2010)

(3) Simulating Emission and Chemical Evolution of Coarse Sea-Salt Particles in Community Multiscale Air Quality (CMAQ) Model

Geoscientific Model Development, 3(1):257-273 (2010)

Kristen Foley

Shawn Roselle

Keith Wyat Appel

Prakash Bhave

Ann Marie Carlton

James Kelly

Jonathan Pleim

Golam Sarwar

Robert Gilliam

Christopher Nolte

Sergey Napelenok

Tanya Otte

Jeffrey Young

David Wong

Rohit Mathur

Alice Gilliland

Edward Edney

George Pouliot

William Hutzell

Jesse Bash

Robert Pinder

Deborah Luecken

Russell Bullock

Donna Schwede

Marc Houyoux

Uma Shankar (Non-EPA)

NERL, Research Triangle Park, NC The Development and Systematic Evaluation of a Substantially Upgraded Air-Quality Modeling System
S13TF0097 Use of Spatially Explicit Physicohemical Data to Measure Downstream Impacts of Headwater Stream Disturbance

Water Resources Research, 46(W09526): (2010)

Brent R. Johnson

Ken M. Fritz

Adam Haas (Non-EPA)

NERL, Cincinnati, OH Predicting Effects of Headwater Stream Disturbance on Downstream Water Quality
Key to Acronyms used in the above Table
OA Office of the Administrator
NERL National Exposure Research Laboratory
NHEERL National Health and Environmental Effects Laboratory
NRMRL National Risk Management Research Laboratory
OAQPS Office of Air Quality Planning and Standards
OPP Office of Pesticide Programs
ORIA Office of Radiation and Indoor Air
OSCP Office of Science Coordination and Policy
ORCR Office of Resource Conservation and Recovery
*Note: The percentages given after name represent the current percent of the total level of effort as documented in the EPA nomination.

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