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Microbiological and Chemical Exposure Assessment

Drinking Water Methods Developed by EPA's Exposure Research Program

EPA's Exposure Research Program has historically been one of the most active EPA programs conducting drinking water methods research. Numerous analytical methods have been written and are available through the NTIS and NEMI.

EPA recommends that programs interested in using these methods for compliance monitoring check the Federal Register to determine if and when these methods are approved.

The methods are presented in Adobe Acrobat ® PDF format. You will need Adobe Acrobat Reader to view PDF files. See EPA's PDF page for more information about getting and using the free Acrobat Reader

Questions or comments about these methods can be addressed to NERL (DWmethods.help@epa.gov) or faxed to 513-569-7757. Additional assistance can be found by contacting the Safe Drinking Water Hotline (hotline-sdwa@epa.gov) or by phone at 1 (800) 426-4791.

  • EPA Method 200.5 (PDF) (36 pp, 468K) - Determination of Trace Elements in Drinking Water by Axially Viewed Inductively Coupled Plasma - Atomic Emission Spectrometery.
  • EPA Method 321.8 (PDF) (25 pp, 171K) - Determination of Bromate in Drinking Waters by Ion Chromatography Inductively Coupled Plasma - Mass Spectrometry.
  • EPA Method 332.0 (PDF) (48 pp, 3.9MB) - Determination of Perchlorate in Drinking Water by Ion Chromatography with Suppressed Conductivity and Electrospray Ionization Mass Spectrometry.
  • EPA Method 415.3 Rev 1.1 (PDF) (56 pp, 1.8MB) - Determination of Total Organic Carbon and Specific UV Absorbance at 254 nm in Source Water and Drinking Water. Revision 1.1, issued in February 2005, reflects a minor change in Section 8.2.
  • EPA Method 415.3 Rev 1.2 (PDF) (56 pp, 368K) - Determination of Total Organic Carbon and Specific UV Absorbance at 254 nm in Source Water and Drinking Water. Revision 1.2, issued in September 2009.
  • EPA Method 521 (PDF) (47 pp, 459K) - Determination of Nitrosamines in Drinking Water by Solid Phase Extraction and Capillary Column Gas Chromatography with Large Volume Injection and Chemical Ionization Tandem Mass Spectrometry (MS/MS).
  • EPA Method 522 (PDF) (41 pp, 302K) - Determination of 1,4-Dioxane in Drinking Water by Solid Phase Extraction (SPE) and Gas Chromatography/Mass Spectrometry (GC/MS) with Selected Ion Monitoring (SIM).
  • EPA Method 525.3 (PDF) (161 pp, 3.40MB) - Determination of Semivolatile Organic Chemicals in Drinking Water by Solid Phase Extraction and Capillary Column Gas Chromatography/Mass Spectrometry (GC/MS)
  • EPA Method 528 (PDF) (46 pp, 118K) - Determination of Phenols in Drinking Water by Solid Phase Extraction and Capillary Column Gas Chromatography/Mass Spectrometry (GC/MS).
  • EPA Method 529 (PDF) (60 pp, 274K) - Determination of Explosives and Related Compounds in Drinking Water by Solid Phase Extraction and Capillary Column Gas Chromatography/Mass Spectrometry (GC/MS).
  • EPA Method 535 Rev. 1.1 (PDF) (61 pp, 633K) - Measurement of Chloroacetanilide and Other Acetamide Herbicide Degradates in Drinking Water by Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS). Revision 1.1, issued in April 2005, reflects a minor change in Section 7.2 and Section 17, Table 4.
  • EPA Method 537 Rev. 1.1. (PDF) (50 pp, 299K) - Determination of Selected Perfluorinated Alkyl Acids in Drinking Water by Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS). Revision 1.1, issued in September 2009, reflects minor changes in Sections 3.1, 9.3, 6.1, 9.3.7 and 10.2.6.
  • EPA Method 538 (PDF) (40 pp, 426K) - Determination of Selected Organic Contaminants in Drinking Water by Direct Aqueous Injection-Liquid Chromatography/Tandem Mass Spectrometry (DAI-LC/MS/MS)
  • EPA Method 540 (PDF) (44 pp, 380K) - Determination of Selected Organic Chemicals in Drinking Water by Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
  • EPA Method 549.2 (PDF) (21 pp, 461K) - Determination of Diquat and Paraquat in Drinking Water by Liquid-Solid Extraction and High Performance Liquid Chromatography with Ultraviolet Detection.
  • EPA Method 556 (PDF) (37 pp, 139K) (jointly developed with OGWDW) - Determination of Carbonyl Compounds in Drinking Water by Pentafluorobenzylhydroxylamine Derivatization and Capillary Gas Chromatography with Electron Capture Detection.

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