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Tirumuru V. Reddy

My skills lie in the areas of gene transcription and general molecular biology. I have investigated the up-regulation of numerous genes in teleosts, induced by estrogenic chemicals and other xenobiotics known to be present in the Nation’s surface waters. These laboratory studies include: (1) vitellogenin gene regulation in male adult fathead minnow exposed to endocrine disrupting chemicals (EDCs) [i.e., nonylphenol (NP), 17α-ethynylestradiol (EE2), 17β-estradiol (E2), and estrone (E1)] and plastisizers, such as 2-diethyl-hexyl phthalate, and (2) metallothionein gene induction in fathead minnow exposed to metals,such as copper, cadmium and zinc. Gene expression data for these studies is generated by employing state-of-the-art techniques, such as reverse transcription polymerase chain reaction (RT-PCR) and real time quantitative PCR. I have developed method for the isolation of RNA from a
single 24 to 48 hour old fathead minnow larvae for use in gene expression studies.

Biographical Information

Name: Tirumuru V. Reddy
Title: Research Chemist

Contact Info:

Ecological Exposure Research Division
National Exposure Research Laboratory
Environmental Protection Agency
26 W. Martin Luther King Jr. Dr. (MD579)
Cincinnati, OH 45268

Phone: 513-569-7295
Email: reddy.tirumuru@epa.gov

Education:

  • Ph.D. in Biochemistry, 1974, Delhi University of Delhi, India
  • M.S. in Biochemistry, 1967, Punjab University, India
  • B.S. in Biochemistry, 1965, Punjab University, India

Professional Experience

  • Research Chemist, USEPA, ORD, 1987 to Present
  • NRC Senior Fellow, USEPA, HERL, 1985 to 1987
  • Research Asst. Professor, University of Pittsburgh School of Medicine, Dept. of Pathology, 1980 to 1985
  • Post Doctoral Fellow, National Institutes of Health, National Cancer Institute, 1977 to 1980
  • Assistant Research Officer, National Institute of Nutrition, 1974 to 1977

Selected Awards and Honors

  • USEPA, Scientific and Technical Achievement Honorable Mention, 2005
  • USEPA/ORD/NERL, Research Grant, 1996 to 1999
  • Strategic Environmental Research and Development Program, Research Grant, 1993 to 1997
  • USEPA, Scientific and Technological Achievement Award, 1992
  • US Army, Research Grants, 1990 to 1995

Publications and Presentations

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