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D   FundingOpportunityNumber: EPAORD_NHEERL_ԄIO001    CatalogofFederalDomesticAssistance(_CFDA_)Number:    0  0`  $ $66.511OfficeofResearchandDevelopmentConsolidatedResearch/Training` $` $   SolicitationOpeningDate:0  November23,2005p $ $ SolicitationClosingDate:0  January6,2006\ $ $  ActionDates: 0 ` (_RFA_Ԁissued)4` $` $ Finaldatetosubmittechnicalquestions:January6,2006 $t Proposalsdue:0 ` January23,2006`` $` $  SUMMARYOFPROGRAMREQUIREMENTS  $  SynopsisofProgram   TheU.S.EnvironmentalProtectionAgency's(EPA)NationalHealthandEnvironmentalEffects   ResearchLaboratory(_NHEERL_)conductsmissionrelatedresearchtobetterdetermine p! toxicologicalhazards,definedoseresponserelationships,andestimatehumanexposure \" characteristicsinsupportoftheAgency'soverallriskassessmentandguidelinedevelopment.We H#  areseekingtoenterintothesecooperativeagreementswhichwillprovidetrainingopportunitiesfor 4$! undergraduates,graduates,andpostdoctoralfellowsonsiteatEPA'sResearchTriangleParkand/or  %p " ChapelHill,NorthCarolinafacilities.Thepurposeoftheseassistanceagreementsistoidentify  &\!# andprovidetrainingforcandidatesintheenvironmentalhealthsciencescurriculumwhoseareasof &H"$ interestscoincidewiththeareasofongoingresearchat_NHEERL_Ԁ(i.e.,_Neurotoxicology_, '4#% _Pharmacokinetics_,Toxicology,_Carcinogenesis_,PulmonaryToxicology,Developmental ( $& Toxicology,ReproductiveToxicology,_Immunotoxicology_,EnvironmentalEpidemiology, ) %' ComputationalToxicology,and_Biostatistics_/Modeling). *%(  ,'* _ԇ  I.FUNDINGOPPORTUNITYDESCRIPTION    Introduction  t TheU.S.EnvironmentalProtectionAgency's(EPA)NationalHealthandEnvironmentalEffects L  ResearchLaboratory(NHEERL)conductsmissionrelatedresearchtobetterdetermine 8  toxicologicalhazards,definedoseresponserelationships,andestimatehumanexposure $ t characteristicsinsupportoftheAgency'soverallriskassessmentandguidelinedevelopment.We  ` areseekingtoenterintoacooperativeagreement(s)whichwillprovidetrainingopportunitiesfor  L  undergraduates,graduates,andpostdoctoralfellowsonsiteatEPA'sResearchTriangleParkand/or  8  ChapelHill,NorthCarolinafacilities. $   XBackground    Thepurposeofthisassistanceagreement(s)istoidentifyandprovidetrainingforcandidatesinthe   environmentalhealthsciencescurriculumwhoseareasofinterestscoincidewiththeareasofongoing p researchatNHEERL(i.e.,Neurotoxicology,Pharmacokinetics,Toxicology,Carcinogenesis,Pulmonary \ Toxicology,DevelopmentalToxicology,ReproductiveToxicology,Immunotoxicology,Environmental H Epidemiology,ComputationalToxicology,andBiostatistics/Modeling).EPAwillhavesignificant 4 involvementinthisprojectbyprovidingscientificmentorsandfacilitiesforselectedcandidates.  p ̀Thissolicitationissubjectto40CFR,Part45oftheEPAgrantregulations.Inaddition,theprojectwill H besubjecttothegeneralregulations(Part31forState,localandIndiantribalgovernments;Part30for 4 otherrecipients).Profitmakingorganizationsareineligibletoapplyunderthelegislationauthorizing   EPA'sassistanceprograms.    =(Uh83K ThespecificGovernmentPerformanceResultsAct(GPRA)Goals,ObjectivesandSubobjectivesthat  relatetothissolicitationinclude:  0  GPRAGoal1CleanAirX %%   ATAirToxics D!    `  0  PMParticulateMatter0" %%    `  Objective6:Science/Research #l! Ѐ   ` 0 Subobjective1.6.1SciencetoSupportAirPrograms$X" % %   GPRAGoal2CleanandSafeWater %0!$    `  0  DWDrinkingWater&"%%% ЀWQWaterQuality   '#& ЀObjective2.3:EnhanceScienceandResearch (#' ЀSubobjective2.3.1ApplytheBestAvailableScience )$(    ` Subobjective2.3.2ConductLeadingEdgeResearch |*%)     GPRAGoal4HealthyCommunitiesandEcosystems T,'+    `  0  SafeCommunities%%    `  0  EndocrineDisruptors%%    `  0  ResearchHumanHealthandEcosystems%%    `  0  ResearchPesticidesandToxics     x t%% ЀObjective4.5ScienceandResearch ` ЀSubobjective4.5.1Science L  ЀSubobjective4.5.2Research 8  RXJXX XJTheEPAsStrategicPlancanbefoundat4ust0CO  5  CO  http://www.epa.gov/ocfo/plan/2003sp.pdfC   CO  .C   6 C   7K# XJXXRXJ#  `  FundingPriorities/Focus   8  Thepurposeofthisassistanceagreement(s)istoidentifyandprovidetrainingforcandidatesinthe   environmentalhealthsciencescurriculumwhoseareasofinterestscoincidewiththeareasofongoing   researchatNHEERL(i.e.,Neurotoxicology,Pharmacokinetics,Toxicology,Carcinogenesis,Pulmonary   Toxicology,DevelopmentalToxicology,ReproductiveToxicology,Immunotoxicology,Environmental   Epidemiology,ComputationalToxicology,andBiostatistics/Modeling). p  AuthorityandRegulations  H ThisresearchisauthorizedunderFederalInsecticide,Fungicide,andRodenticideAct,PublicLaw92  p 516,Section20,asamended;ToxicSubstancesControlAct,Section10,asamended;CleanWaterAct,  \ asamended,Sec.104;SafeDrinkingWaterAct,asamended,Sec1442;ComprehensiveEnvironmental H Response,Compensation,andLiabilityAct,Sec311;CleanAirAct,asamended,Sec103;andSolid 4 WasteDisposalAct,asamended,Sec8001.    EnvironmentalOutputsandOutcomes   Theoutcomeofthesetrainingcooperativeagreementswillbeadditionalopportunitiesforassistanceand  trainingforundergraduates,graduates,andpostdoctoralcandidatesintheenvironmentalhealthsciences. l TheseresearchopportunitiesareofinteresttoEPAbecausethetraineesresearchworkisrelevantto X  NHEERLresearchprogramsandwillresultinabetterunderstandingoftoxicologicalhazards,dose D! responserelationships,andestimationofhumanexposurecharacteristicsinsupportoftheAgency's 0"  overallriskassessmentandguidelinedevelopment #l! Outputsfromthesetrainingcooperativeagreementswillbeopportunitiesfortrainingofcandidates $D # affiliatedwithvariousuniversitiesbyprovidingthecandidatesfinancialassistanceduringtheirtraining %0!$ andaffordingthemtheuseofhighlyspecializedlaboratoryfacilitiesandequipment.Additionally,the &"% traineesareprovidedtheopportunityforspecificmentoring/guidancebynationally/internationally '#& recognizedseniorscientistsatNHEERL. $  (#'  GeospatialInformation.  |*%)   RXJXX XJTheseawardsmayinvolvethecollectionof GeospatialInformation,whichincludeinformation T,'+ thatidentifiesthegeographiclocationandcharacteristicsofnaturalorconstructedfeaturesorboundaries  ontheEarthorapplications,tools,andhardwareassociatedwiththegeneration,maintenance,or  distributionofsuchinformation.Thisinformationmaybederivedfrom,amongotherthings,  GeographicPositioningSystem(GPS),remotesensing,mapping,charting,andsurveyingtechnologies, t orstatisticaldata.# XJXXRXJ-+#* `  II.0  AWARDINFORMATION $ t%%     EstimatedTotalDollarAmountofAnnouncement: $12,000,000.00  L  0  AmountandRangeofIndividualAward(s): $300,000.00$5,000,000.00( %% 0  NumberofAwards: Approximatelyfive %%    0  Funding: TheEPAisexpectedtofundthisawardoveraperiodof5years.Fundingforthefirst   yearoftheawardisexpectedtobearangeof$60,000to$1,000,000.00peraward,depending  uponthenumberoftraineesprovidedundereachaward.Additionalfundingduringthesecond l yearwillbecontingentuponavailabilityoffundsandsatisfactoryprogressbytheselected X recipients.Incrementalfundingoftheagreement(s)islikely,dependingontheavailabilityof D funds,thenumberoftrainees,andwhentheybegintheirtrainingprogram.0%% 0  ProjectPeriod: September1,2006throughAugust31,2011X%% 0  SupplementalApplications: ApplicationsforsupplementalawardsofexistingEPAassistance 4 agreementswillnotbeeligibletocompeteforthisassistanceopportunity.$%% 0  TypeofAward: Approximatelyfivecooperativeagreements.%% 0  AnticipatedFederalInvolvement: EPAandtheProjectOfficerforthisassistanceagreement  anticipatesubstantialinvolvementintheimplementationoftheresearchasfollows:x %%    (5h08=  1. ` Providementorshipandfacilitiesfortrainees;and P"  5! !  2.0 ` Participateinthedevelopmentandpreparationofjournalarticlesontheseactivities. #"` %` %  0  EPAreservestherighttorejectallproposalsandmakenoawards.% $%%  ! ! I(uh80III.ELIGIBILITYINFORMATION  :)$(  EligibleApplicants +b&*  ForcertaincompetitivefundingopportunitiesunderthisCFDAprogramdescription,theAgencymay ,:(, limitelegibilitytocompetetoanumberorsubsetofeligibleapplicantsconsistentwiththeAgencys  AssistanceAgreementCompetitionPolicy.Institutionsofhighereducationandnotforprofit  institutionslocatedintheU.S.;andTribal,stateandlocalgovernmentsareelegibletoapply.    ! !EligiblenonprofitorganizationsincludeanyorganizationsthatmeetthedefinitionofnonprofitinOMB ` CircularA122.However,nonprofitorganizationsdescribedinSection501(c)(4)oftheInternal L  RevenueCodethatengageinlobbyingactivitiesasdefinedinSection3oftheLobbyingDisclosureAct 8  of1995arenoteligibletoapply.UniversitiesandeducationalinstitutionsmustbesubjecttoOMB $ t CircularA21.-v>  `  CostSharing   8  Costsharingisnotrequired.    SpecialRequirements    Thecriteriausedtoevaluateproposalsinclude: p 0  AdministrativeReview:Allapplicationpackageswillbesubjecttoanadministrativereviewto H ensurethattheyconformwiththerequirementsofthisRFA.EPAmayrejectanyapplications 4 thatfailtoconformsubstantiallywiththerequirementsofthisRFA. p%% 0  RelevanceReview:Applicationpackagesthatarefoundadministrativelyacceptablewillbe H subjectedtoareviewforrelevancytoEPAsmissiontosupportadvancementofenvironmental 4 science.Applicationpackageswillberejectediftheyarefoundtolackrelevance. %% <v>ClosecollaborationwithEPApreceptorsisessentialtothesetrainingagreements;therefore,  demonstratedabilitytoperformtheworkatEPAfacilitiesinResearchTriangleParkandChapelHill,  NorthCarolinaisrequired.@v>  RXJXX XJApplicationsthatdonotsubstantiallycomplywiththeapplicationsubmissioninstructionsand X  requirementssetforthinthissectionwillberejected.Inaddition,whereapagelimitisexpressedinthis D! sectionwithrespecttopartsoftheapplication,pagesinexcessofthepagelimitationwillnotbe 0"  reviewed.ApplicationsmustbereceivedbytheEPAonorbeforethesolicitationclosingdatepublished #l! inthisannouncement.Applicationsreceivedafterthepublishedclosingdatewillbereturnedtothe $X" senderwithoutfurtherconsideration.Also,applicationsexceedingthefundinglimitsdescribedherein $D # willbereturnedwithoutreview.# XJXXRXJA#Av> %0!$ Groupsoftwoormoreeligibleapplicantsmaychoosetoformacoalitionandsubmitasingleapplication '#& forthisassistanceagreement.Coalitionsmustidentifywhicheligibleorganizationwillbetherecipient (#' oftheassistanceagreement,andwhicheligibleorganizations(s)willbesubawardeesoftherecipient. )$( Subawardsmustbeconsistentwiththedefinitionofthattermin40CFR30.2(ff).Therecipientmust |*%) administertheassistanceagreement,isaccountabletoEPAforproperexpenditureofthefunds,andwill h+&* bethepointofcontactforthecoalition.Asprovidedin40CFR30.2(gg),subrecipientsareaccountable T,'+ totherecipientforproperuseofEPAfunding.  Coalitionsmaynotincludeforprofitorganizationsthatwillprovideservicesorproductstothe  successfulapplicant.Forprofitorganizationsarenoteligibleforsubawards.Anycontractsforservices t orproductsfundedwithEPAfinancialassistancemustbeawardedunderthecompetitiveprocurement ` proceduresof40CFRPart30.Theregulationsalsocontainlimitationsonconsultantcompensation. L  Applicantsarenotrequiredtoidentifycontractorsorconsultantsintheproposal.Moreover,thefacta 8  successfulapplicanthasnamedaspecificcontractororconsultantintheproposalEPAapprovesdoes $ t notrelieveitofitsobligationstocomplywithcompetitiveprocurementrequirementsorconsultant  ` compensationlimitations.  L  RXJXX XJ# XJXXRXJL# RXJXX XJIV.APPLICATIONANDSUBMISSIONINFORMATION     Youmaysubmiteitherapaperapplicationpackageoranelectronicapplicationpackage(butnot   both)forthisannouncement.Instructionsforbothformsofsubmissionfollow.   # XJXXRXJbL#RXJXX XJ9Ev># XJXXRXJM#Forapaperapplicationpackage,youmayrequestanapplicationpackagefrom: BarryHoward, \ MD10501,U.S.EnvironmentalProtectionAgency,OfficeofResearchandDevelopment,National L HealthandEnvironmentalEffectsResearchLaboratory,OfficeoftheAssociateDirectorofHealth,109 8 T.W.AlexanderDrive,ResearchTrianglePark,NorthCarolina27711,or4t CO  5  howard.barry@epa.gov.6OCOOsear  7V&PԀ $t ApplicationinformationisalsoavailablefromtheEPA/ORD/NHEERLwebsiteat ` M4relCO  5  http://www.epa.gov/nheerl/about/researchopportunities.html69QCOMQicat  7ApH{Q{WԀR4pApzCO  5  6ARCOURicat  7ApzR{WԀundertheheadingAssistance L Opportunities.Thisdocument,andanysubsequentamendments,constitutestheentireRequestfor 8 Applications.Theapplicationpackagemustbesubmittedintheoriginalwith3copiesandmustbe $ doublesided,consecutivelynumbered(bottomcenter),minimumfontsizeof12,singlespaced,with1  inchmargins.   ForsubmissionofanelectronicapplicationpackagethruGrants.gov,seeSectionH:Guidelines,  Limitations,andAdditionalRequirementsR{W:OtherSubmissionRequirements.Electronic p submissionsthruGrants.govmustalsocomplywiththepagelimitationsandfontrequirements \  above. RXJXX XJ  H!  ContentandFormofApplicationSubmission   #p! Theapplicationpackageismadebysubmittingthematerialsdescribedbelow.Itisessentialthatthe $H # applicationpackagecontainallinformationrequestedandbesubmittedintheformatsdescribed.# XJXXRXJ:V#RXJXX XJ %4!$ ApplicationsthatdonotcomplywiththesubstantialcompliancelanguageinSectionIIIwillberejected. & "% # XJXXRXJW#iU{W A.StandardForm424  (#' TheapplicantmustcompleteformSF424(4T`CO  5  http://www.epa.gov/ogd/forms/forms.htm6YCO'YX  7XeY.Thisformwillbe *%) thefirstpageoftheapplication.InstructionsforcompletionoftheSF424areincludedwiththeform. l+&* Theformmustcontaintheoriginalsignatureofanauthorizedrepresentativeoftheapplyinginstitution. X,'+ PleasenotethatboththePrincipalInvestigatorandanadministrativecontactmustbeidentifiedinItem5  oftheSF424.  Applicantsarerequiredtoprovidea DunandBradstreetDataUniversalNumberingSystem(DUNS) t numberinItem5whenapplyingforfederalgrantsorcooperativeagreements.Organizationsmay ` receiveaDUNSnumberbycalling18667055711orbyvisitingthewebsiteat4QbyCO  5  CO  C ]  CO  Xhttp://www.dnb.comC]  6 ]C  7by( ^]. L  SomestateshaveanintergovernmentalreviewrequirementunderExecutiveOrder12372, $ t  IntergovernmentalReviewofFederalPrograms.Item16oftheSF424referstothisrequirement.  ` Applicantsshouldconsulthttp://www.whitehouse.gov/omb/grants/spoc.htmltodeterminewhethertheir  L  stateparticipatesinthisprocessandhowtocomply.4^  8   RXJXX XJB.KeyContacts    Theapplicantmustcompletethe KeyContactsformasthesecondpageoftheapplication;theKey   Contactscontinuationpageisalsoavailableat`4s00CO  5  http://www.epa.gov/ogd/forms/forms.htm6aCOatha  7nob.ԀTheKey   Contactsformmustalsobecompletedformajorsubagreements(i.e.,contactsattheinstitutionsfor p primarycoinvestigators).Pleasemakecertainthatallcontactinformationisaccurate.Anemailwillbe \ sentfromtheNHEERLcontacttothePrincipalInvestigatorandtheAdministrativeContactto H acknowledgereceiptoftheapplicationandtransmitotherimportantinformation.Iftheapplicantdoes 4 notreceiveanemailacknowledgmentwithin30daysofthesubmissionclosingdate,theapplicantshall  p immediatelycontacttheTechnicalContactlistedunder"AgencyContacts"inthissolicitationtoensure  \ thattheirsubmissionhasbeenreceived.See SubmissionInstructionsforElectronicApplicationsfor H additionalinformationregardingacknowledgmentofreceiptofelectronicallysubmittedapplications. 4 # XJXXRXJ`#  RXJXX XJ C.TableofContents    Providealistofthemajorsubdivisionsoftheapplicationindicatingthepagenumberonwhicheach  sectionbegins.(ATableofContentsisnotrequiredforelectronicsubmissions.)   D.TechnicalProposal  X  # XJXXRXJf#Provideatechnicalproposalthatdiscussestheapproachtoaccomplishingthegoalsstatedunder 0"  FundingPriorities/Focus,theenvironmentaloutputsandoutcomes,theprogrammaticcapability, #l! includingpersonnelandfacilitiesoftheapplicanttocompletetheresearch,theexpectedresultsfromthis $X" research,howtheresearchwilladvanceandstimulatethepublicneed,andhowtheresultswillbemade $D # availabletothepublicandgovernment.RXJXX XJApplicantsmustsubmitaplanfortrackingandmeasuring %0!$ progresstowardachievingtheexpectedoutputsandoutcomes# XJXXRXJhj#ԀincludedinSectionIofthis &"% announcement.Indevelopingthetechnicalproposal,theapplicantmustfocusontheevaluationcriteria '#& setforthinSectionVandstructuretheproposaltoaddresseachofthecriteriaintheorderlisted.In (#' addition,EPAwillconsiderinformationprovidedbytheapplicantandmayconsiderinformationfrom )$( othersources,suchasAgencyfiles. |*%) Thepagelimitationofthetechnicalproposalis158.5x11inchdoublesidedpages(30pagestotal), T,'+ consecutivelynumbered(bottomcenter),withaminimumfontsizeof12pointtype,singlespaced,with  1inchmargins.Thispagelimitationmustincludealltext,tables,figures,references,attachments,and  appendiceswhichcomprisethetechnicalproposal.   E.QualityAssuranceStatement `  RXJXX XJProvideaQualityManagementPlanthatdescribestheapplicant# XJXXRXJo#SX / XX XJ*# XJX XSX /o#RXJXX XJsqualitysystemforitsorganization. 8  ThePlanmustbepreparedinaccordancewiththespecificationsprovidedin# XJXXRXJo#RXJXX XJEPARequirementsfor $ t QualityManagementPlans# XJXXRXJp#RXJXX XJԀ# XJXXRXJ%q#RXJXX XJ(QA/R2)# XJXXRXJkq#RXJXX XJoraddressthesametopicsasrequiredbyQA/R2.# XJXXRXJq#RXJXX XJԀQA/R2# XJXXRXJ/r#RXJXX XJmaybe  ` downloadedfromtheInternetat# XJXXRXJ|r#RXJXX XJԀ# XJXXRXJr#RXJXX XJhttp://www.epa.gov/quality/qa_docs.html# XJXXRXJDs#RXJXX XJԀ# XJXXRXJs#.RXJXX XJThePlanmustnotexceed  L  twoconsecutivelynumbered(bottomcenter),8.5x11inchpagesofsinglespaced,standard12ponttype  8  with1inchmargins.# XJXXRXJs#ԀThisinformationisseparatefromthetechnicalproposal. $   F.BudgetandBudgetJustification    Budget   Provideabudgetestimatefortheprojectthatisbrokendownintodirectlabor,fringebenefits, \ equipment,travel,otherdirectcostsandoverheadwithsummariesforeachyearandthetotalforthe H entireproject.FormsareavailableatRXJXX XJԀ4N00 CO  5  http://www.epa.gov/ogd/forms/forms.htm6vCOvtha  7no!w# XJXXRXJv#. 4 BudgetJustification  \ RXJXX XJDescribethebasisforcalculatingthepersonnel,fringebenefits,travel,equipment,supplies,contractual 4 support,andothercostsidentifiedintheitemizedbudget.Thebudgetjustificationmustnotexceedtwo   consecutivelynumbered(bottomcenter),8.5x11inchpagesofsinglespaced,standard12ponttypewith   1inchmargins.# XJXXRXJx#  Thisinformationisseparatefromthetechnicalproposal.   G.ResumesandCurrentandPendingSupport  l ̀Provideresumesfortheprincipalinvestigatorandanyotherkeypersonnelidentifiedintheproposal. D! TheresumeforeachindividualmustnotexceedtwoRXJXX XJԀconsecutivelynumbered(bottomcenter),8.5x11 0"  inchpagesofsinglespaced,standard12ponttypewith1inchmargins.# XJXXRXJ={#ԀThisinformationisseparate #l! fromthetechnicalproposal. $X"  H.Guidelines,Limitations,andAdditionalRequirements  %0!$ Confidentiality '#& RXJXX XJBysubmittinganapplicationinresponsetothissolicitation,theapplicantgrantstheEPApermissionto )$( makelimiteddisclosuresoftheapplicationtotechnicalreviewersbothwithinandoutsidetheAgency |*%) fortheexpresspurposeofassistingtheAgencywithevaluatingtheapplication.Informationfroma h+&* pendingorunsuccessfulapplicationwillbekeptconfidentialtothefullestextentallowedunderlaw; T,'+ informationfromasuccessfulapplicationmaybepubliclydisclosedtotheextentpermittedbylaw.  Inaccordancewith40CFR2.203,applicantsmayclaimalloraportionoftheapplication/proposalas  confidentialbusinessinformation(e.g.,intellectualproperty).EPAwillevaluateconfidentialityclaims t inaccordancewith40CFRPart2.Applicantsmustclearlymarkapplications/proposalsorportionsof ` applications/proposalstheyclaimasconfidential.Ifnoclaimofconfidentialityismade,theEPAisnot L  requiredtomakeaninquirytotheapplicantotherwiserequiredby40CFR2.204(c)(2)priorto 8  disclosure.# XJXXRXJ|# $ t  SubmissionDatesandTimes   L   MXJXX XJTobeconsideredtimely,paperapplicationpackages(oneoriginalandthree(3)copies)mustbe $  receivedbytheProjectOfficernolaterthan4:00pmlocaltimeonԀMonday,January23,20060Ԁfromthe   U.S.PostalServiceorothercommercialdeliveryservice.# XJXXMXJX#ԀPackagesshallbesubmittedtoBarryHoward,   ProjectOfficer,U.S.EnvironmentalProtectionAgency,OfficeofResearchandDevelopment,National   HealthandEnvironmentalEffectsResearchLaboratory,OfficeoftheAssociateDirectorofHealth,MD   B10501,109T.W.AlexanderDrive,ResearchTrianglePark,NorthCarolina27711.MXJXX XJPackagesreceived p afterthedeadlinewillnotbeconsideredandwillbereturnedtothesubmitter.Applicantsthatsubmit \ packagesbyhandmayrequestareceiptfromthesecurityguardatthemainentranceoftheU.S.EPA H facilityat109T.W.AlexanderDrive,ResearchTrianglePark,NC.# XJXXMXJn#ԀElectronicsubmissionsmayalsobe 4 acceptedinthemannerdescribedbelow.  p Ѐ Amendments H  Amendmentswillbepostedonthiswebsiteandtheduedateforapplicationpackageswillbeextended   ifdeemedappropriate.    OtherSubmissionRequirements   RXJXX XJSubmissionInstructionsforElectronicApplicationPackagesUsingGrants.gov l Theelectronicapplicationpackageavailablethroughthe4{de]CO  5  CO  http://www.grants.govCd  6PCicer  7de/websitemustbeused D! forelectronicsubmissions.Inordertoviewtheapplicationpackage,downloadthePureEdgeviewer 0"  (hyperlinkavailableunder GetStartedthen GetStartedStep2").Theapplicationpackagemaybe #l! quicklyaccessedfrom4|deACO  5  CO  https://apply.grants.gov/forms_apps_idx.htmlCicer  6Cicer  7demԀusingeithertheCFDAnumberof $X" 66.511orFundingOpportunityNumber # XJXXRXJ#MXJXX XJ EPAORDNHEERLIO001# XJXXMXJ[#RXJXX XJ.Itisrecommendedthatyou $D #  RegistertoReceiveNotificationofannouncementupdates. %0!$ Theactualsubmissionofanelectronicapplicationmustbemadebyanauthorizedorganizational '#& representative(AOR)ofthesubmittinginstitutionwhoisregisteredwithGrants.gov(mostindividual (#' investigatorswillnotbeeligibletosubmittheapplication).Pleasesee4}+CO  5  CO  http://www.grants.gov/Cicer  6Cicer  7ڏ, Get )$( Startedforfurtherinformation. Theregistrationprocessmaytakeaweekorlongertocomplete.  |*%) PleasecheckwithyourSponsoredProgramsorequivalentofficetolocateyourAORandseeifyour h+&* institutionisregistered.Ifyourinstitutionisnotcurrentlyregistered,encourageyourAORtobeginthe T,'+ processimmediately.  Thecompleteapplicationpackage mustbetransferredthroughGrants.govnolaterthan4:00pm  EasternTime onthesolicitationclosingdate(see SubmissionDatesandTimesabove).Anemail t willbesentbytheNHEERLProjectOfficertothePrincipalInvestigatorandtheAdministrativeContact ` toacknowledgereceiptoftheapplicationandtotransmitotherimportantinformation.Ifanemail L  acknowledgmentfromNHEERL(notsupport@grants.gov)hasnotbeenreceivedwithin30daysofthe 8  submissionclosingdate,immediatelycontactthetechnicalcontactlistedunder"AgencyContacts"in $ t thissolicitation.Failuretodosomayresultinyourapplicationnotbeingreviewed.  ` DocumentsmustbesubmittedinAdobeAcrobatPDFformattomaintainformatintegrity.Please  8  submittherequireddocumentsasdescribedbelow.ATableofContentsisnotrequiredforelectronic $  submissions.   OntheelectronicGrantApplicationPackagepage,enterthePrincipalInvestigatorsname,startingwith   thelastname,inthe ApplicationFilingNamefield.   ua,X4` hp x %#%'0*,.8135@8:<H?AXuA.  ApplicationforFederalAssistance(SF424) \   Completetheform.Therearenoattachments. H B.  EPAKeyContactsForm570054  p   1.  Completetheform.  \   2.  Ifadditionalpagesareneeded,see F.OtherAttachmentsFormbelow. H Whataboutthetableofcontentsthatisrequiredforhardcopy 4 C.  TechnicalProposalandQualityAssuranceStatement     CompiletheTechnicalProposalfollowedbytheQualityAssuranceStatementintoonedocument   labeled 4 TechnicalProposalQAandsubmititasthe AddMandatoryProjectNarrativeFile.See  Section4oftheannouncementforfurtherinformationregardingthecontentofthetechnicalproposal  andQualityAssuranceStatement.  D.BudgetNarrativeAttachmentForm X    1.  Wherepossible,prepareonedocumentforyourBudgetandBudgetJustification,labelthis D! document 4 BudgetAndJustification,andsubmititasthe AddMandatoryBudgetNarrative. 0"  0  2.  IfyoucannotcompileyourBudgetandBudgetJustificationintoonedocument,prepareone #l! documentforeach.$X"%%     a. 4 LabelyourBudgetdocumentBudgetandsubmititasthe AddMandatoryBudget $D # Narrative. %0!$ 0  0%%04%%  b. 4 LabeltheBudgetJustificationdocumentBudgetJustificationandsubmititasan Add &"% OptionalBudgetNarrativedocument.'#&4%4% a,X4` hp x %#%'0*,.8135@8:<H?A ,X, X%#%X zwwwwwwwww(88I! !E.ResumesandCurrentandPendingSupport )$( 0  0%%  PrepareonedocumentcontainingallResumesfollowedbyCurrentandPendingSupport,labelit |*%) Resumes,andsubmititasan AddOptionalProjectNarrativeFile.h+&*%%  I(uh88zwwwwwwwww[# XJXXRXJ#RXJXX XJ T,'+ F.  OtherAttachmentsForm  0  1.  IfKeyContactsContinuationpagesareneededfortheKeyContactsForm570054,compile  themintoonedocumentlabeledContactsContinuationandsubmitthedocument.%%   2.  Otherappropriatedocumentsmayalsobesubmittedhere. t Oncetheapplicationpackagehasbeencompleted,the Submitbuttonwillbecomeactive.Saveyour L  completedapplicationpackagewithtwodifferentfilenamesbeforeprovidingittoyourAORtoavoid 8  havingtorecreatethepackageshouldsubmissionproblemsbeexperienced.Submissionofthe $ t applicationpackagemustbecompletedbyyourAOR.  ` Pleasecloseallothersoftwarebeforeattemptingtosubmittheapplicationpackage.Ifyouexperience  8  submissionproblems,pleaserebootyourcomputer(turningthepoweroffmaybenecessary)andre $  attemptthesubmission.Ifyoucontinuetoexperiencesubmissionproblems,contactGrants.govfor   assistance(Phone:18005184726,Email:48 CO  5  CO  support@grants.govCicer  6Cicer  7.>C).Ifsubmissionproblemsarenot   quicklyresolved,contacttheNHEERLProjectOfficer,BarryHoward(Phone:9195412729,Email:4.CO  5  CO  CƩicer  6Cicer  7.# XJXXRXJ#    howard.barry@epa.gov.    RXJXX XJV.APPLICATIONREVIEWINFORMATION  \  # XJXXRXJ%#MXJXX XJOnlyapplicationpackagesthatmeettheadministrativereviewandrelevancereviewwillbesubjectto 4 thetechnicalreviewdescribedbelowandbeeligibleforaward.Packagesfromeligibleapplicantsthat  p aredeemedineligibleforawardorthatfailtomeeteithertheadministrativerevieworrelevancereview  \ willbereturnedwithoutfurtherreview. H # XJXXMXJ#    0  RXJXX XJCriteriaforTechnicalReview: # XJXXRXJȭ# %% 0  1.Competencyoftheproposedfacultytoaccomplishtheprojectobjectives,includingthetechnical  capabilityoftheapplicantorrecipienttosuccessfullycarryoutprojectobjectivestakingintoaccount  suchfactorsastheapplicants:(i)pastperformanceinsuccessfullycompletingfederallyand/ornon  federallyfundedprojectssimilarinsize,scope,andrelevancetotheprojectobjectives,(ii)historyof l meetingreportingrequirementsonpriororcurrentassistanceagreementswithfederaland/ornon X  federalorganizationsandsubmittingacceptablefinaltechnicalreports,(iii)organizational D! experienceandplanfortimelyandsuccessfullyachievingtheobjectivesoftheproject,and(iv)staff 0"  expertise/qualifications,staffknowledge,andresourcesortheabilitytoobtainthem,tosuccessfully #l! achievethegoalsoftheproject.(30%)$X"%% 0  2.Adequacyandrelevanceoftheuniversitycurriculumtotheobjectivesofthetrainingexperienceat %0!$ NHEERL.(30%)&"%%% 0  3.Theproposedmeritbasedcompetitiveprocedurestobeutilizedintheselectionoftrainees(10%)(#'%% 0  4.Costeffectivenessofbudgetrelativetoaccomplishingthetrainingobjectives.(10%)|*%)%% 0  5.Understandingofenvironmentalsciences,astheyrelatetoresearchtraining(10%)T,'+%% POY  P P    0  6.Applicantsplanformeasuringandtrackingitsprogresstowardachievingtheexpectedoutput  andoutcomesdescribedinSectionI(10%).%%   0   %%  ReviewandSelectionProcess  ` EvaluationProcess:TheadministrativeandrelevancyreviewswillbeconductedbyEPApersonnelwho 8  arenotpartofthetechnicalreviewpanel.Thereviewofthetechnicalreviewcriteriawillbeconducted $ t byatechnicalreviewpanel;thetechnicalreviewpanelshallconsistofatleastoneinternalEPA  ` reviewer(outsideofNHEERL)andatleasttwononEPAreviewerswhoareabletodemonstrate  L  technicalexpertiseintheareasrelatedtotheRFAandDONOTHAVEanyconflictsofinterest.  8  SourceSelection:EPAwillmakeaselectionoftheapplicant(s)foraward(s)basedupontherankings   ofthetechnicalreviewpanel.TheDecisionOfficialisanOfficeofResearchandDevelopment(ORD)   managerwhowilldeterminewhichapplicant(s)shouldreceivetheaward(s)basedonthetechnicalpanel   recommendation.        4 RXJXX XJVI.AWARDADMINISTRATIONINFORMATION  H  AwardNotices # XJXXRXJr#  p   NoticeofawardwillbemadeinwritingbyanofficialintheEPAGrantsAdministrationDivision. H PreliminaryselectionbytheDecisionOfficialintheOfficeofResearchandDevelopmentdoesnot 4 guaranteeanawardwillbemade.Applicantsarecautionedthatonlyagrantsofficercanbindthe   Governmenttotheexpenditureoffunds.NocommitmentԀonthepartofEPAshouldbeinferredfrom   technicalorbudgetarydiscussionswithanEPAProgramOfficial.APrincipalInvestigatoror  organizationthatmakesfinancialorpersonnelcommitmentsintheabsenceofagrantorcooperative  agreementsignedbytheEPAGrantsAwardOfficialdoessoattheirownrisk.EPAwillpromptlynotify  inwriting(postaloremail)thoseapplicantswhoseproposalisrejected. l  RXJXX XJDisputes  D! Disputesrelatedtothisassistanceagreementcompetitionwillberesolvedinaccordancewiththedispute #l! resolutionproceduressetforthin70FR3629,3630(January26,2005)whichcanbefoundat $X" 4v(CO  5  CO  http://www.epa.gov/ogd/competition/resolution.htmC/icer  6Cicer  7(].Questionsregardingdisputesmaybereferredto $D # theAgencyContactidentifiedinsectionVII. %0!$ # XJXXRXJ# AdministrativeandNationalPolicyRequirements  '#& RegulationsandOMBCoverage: )$( Grantsandagreementswithinstitutionsofhighereducation,hospitals,andothernonprofitorganizations l+&* aresubjectto40CFRParts30and40andOMBCircularA122fornonprofitsandA21forinstitutions X,'+ ofhigherlearning.  Grantsandagreementswithstate,local,andtribalgovernmentsaresubjectto40CFRParts31and40  andOMBCircularA87. t ProgrammaticTermsandConditions:Termsandconditionswillbenegotiatedwiththeselected L  recipientcoveringthefollowingrequirements: 8       4  ` Anacceptablequalityassurancedocument,i.e.,QualityAssuranceProjectPlan(QAPP),shallbedue  ` within45calendardaysofaward.  L  Tofurthertheassistanceagreementobjectivesofpublicsupportandstimulation,applicantsmustagree $  tomakemethods,models,anddataresultingfromthisagreementaccessibletothepublicandtoEPA   researchers.   ThenatureandextentofcollaborationbetweenEPAandtherecipient.   Allnonprofitapplicantswhichqualifyforfundingunderthisannouncmentmay,dependingonthesize \ oftheaward,berequiredtofilloutandsubmittotheEPAGrantsAdministrationDivision,with H supportingdocuments,theAdministrativeCapabilityFormcontainedinAppendixAofEPAOrder 4 5700.8.  p  Reporting  H QuarterlyProgressReports:Theselectedrecipientshallsubmitquarterlyprogressreports(hardand   electroniccopies)summarizingtechnicalprogress,difficultiesencountered,andplannedactivitiesfor   thenextquarter.Eachreportshallincludeasummaryofexpendituresandprojections.Theselected  recipientshallsubmitthesequarterlyprogressreportswithinfourteen(14)calendardaysoftheendof  therespectivequarter.  FinalReport:Theselectedrecipientsshallsubmitafinalreport(hardandelectronic)within90calendar X  daysofthecompletionoftheperiodofperformance. D!  RXJXX XJVII.AGENCYCONTACT # XJXXRXJ#0  #l!%%   TheprimaryagencycontactforthisRFAisBarryHowardat: $D # {0  U.S.EnvironmentalProtectionAgency&"%%%   OfficeofResearchandDevelopment '#&   NationalHealthandEnvironmentalEffectsResearchLaboratory (#'   OfficeoftheAssociateDirectorofHealth,MDB10501 )$(   109T.W.AlexanderDrive |*%)   ResearchTrianglePark,NorthCarolina27711 h+&* 0  Telephone:(919)5412729T,'+%%   Telefax:(919)5412729      Email:howard.barry@epa.gov  0  MXJXX XJIfunabletoreachBarryHoward,pleasecontactMs.MargaretMannat:t%% <X(#'X ,X, X%#%X<   ` Telephone:(919)5414896 `    ` Telefax::(919)5412581 L     ` Email:mann.margaret@epa.gov 8  @ ,X, X%#%XX(#'Xq@# XJXXMXJ# VIII. OTHERINFORMATION   L   Questions (   QuestionsmustbesubmittedinwritingtoBarryHoward.MXJXX XJԀDonotattempttoseekinformation   regardingthisRFAfromanysourceotherthanthoseidentifiedinSectionVIIastheinformation   providedmaybeerroneous.Answerstosignificantclarifyingquestionswillbepostedonawebsite.If   thereisamaterialchangetotheRFA(i.e.,anextensionoftheduedate,increaseordecreaseinfunding, t changeincriteria),thenanamendmentwillbemadetothisRFAandpostedonthewebsite.# XJXXMXJ# `      4  ` W.` hp x (# ,X, X%#%XW0