WPC =*](ǧ5xL(Ot/zo6<!fpF6uZ~9+M (_22   &hhp x &23  ..  5+ ` hp x 5  *;+M (_21   #p x #23  ..  5+ ` hp x 5  *8+M (_20  h  p x 23  ..  5+ ` hp x 5  *5+M (_19   pp x 23  ..  5+ ` hp x 5  *2+M (_18    x 23  ..  5+ ` hp x 5  * (_1723  Ԁ*GM (_16   /%` ` hp x /23  Ԁ  5+ ` hp x 5  *DM (_15   ," hp x ,23  Ԁ  5+ ` hp x 5  *AM (_14  ` ) hp x )23  Ԁ  5+ ` hp x 5  *>M (_13   &hhp x &23  Ԁ  5+ ` hp x 5  *;M (_12   #p x #23  Ԁ  5+ ` hp x 5  *8M (_11  h  p x 23  Ԁ  5+ ` hp x 5  *5M (_10   pp x 23  Ԁ  5+ ` hp x 5  (2M &_9    x 23  Ԁ  5+ ` hp x 5  ( &_823  (GM &_7   /%` ` hp x /23   5+ ` hp x 5  (DM &_6   ," hp x ,23   5+ ` hp x 5  (AM &_5  ` ) hp x )23   5+ ` hp x 5  (>M &_4   &hhp x &23   5+ ` hp x 5  (;M &_3   #p x #23   5+ ` hp x 5  (8M &_2  h  p x 23   5+ ` hp x 5  (5M &_1   pp x 23   5+ ` hp x 5  &2M $_    x 23   5+ ` hp x 5  !USUS.,  _QuestionsforStudiestoDevelopScreeningToolsforYoungChildrenatRiskfor  EnvironmentallyMediatedNeurobehavioralDisorders  1.IsEPAinterestedintestingalternatehypothesesratherthanpursuingthecurrentapproach, k examinationofclinicalrecords,asdescribedintheRFIP? T Forthepurposesofthisstudy,EPAwillbesupportingresearchtoexpandadatabaseonpotential & v predictorsofbehavioraldisordersthroughtheexaminationofclinicalrecords.Alternate  _ hypotheseswillnotbetestedunderthisstudy.  H 2.ThefulltextannouncementcitestheDukeUniversitystudiesbutdoesnotidentifywhere(if   any)Icangetacopyoftheresults,especiallythescreeningquestionnaires.Canyouhelp?   DukestudiesarenotcitedintheRFIP.ThereisareferenceintheRFIPtoadatabasedeveloped n  bysearchingrecordsfromtheDukeADHDclinic.Theclinicalrecordsarenotavailabletothe W  EPA,norisinformationregardingspecifictestsorquestionnaires.Thedatabase,when @ completed,willbecomeEPApropertyandwillnotbepublicallyavailable. )y 3.Isthisthefirsttimethatthisprogramhasbeensolicitedcompetitively? 4 Yes.  4.Althoughnocostsharingisrequiredofapplicantsaccordingtotheprogramannouncement, q wouldapplicantswhoprovidedamatchbescoredhigherinthereviewprocess? Z ApplicantswillbeevaluatedandscoredbasedstrictlyonthecriterialistedundersectionV. ,| ApplicationsReviewInformationoftheRequestforInitialProposal(RFIP).Costsharingisnot e listedasoneoftheevaluationcriteria. N 5.Areapplicantsadvisedtocontactyoubeforeapplying,oronlyiftheyhavequestions? !   ApplicantsshouldcontacttheUSEnvironmentalProtectionAgencywithspecificquestions. #" 6.SincetheprojectistoexpandworkpreviouslyconductedbyDuke,whataccesswillwehave ]&!% totheDukedatabase,andwhattypeofinformationhasbeencollectedthere?Arethereany F'"& publicationsfromthisdatabasethatwecanreferencewhenwearewritingourproposal? /(#' ThedatabasecreatedbyDukefromrecordscollectedintheirADHDclinichasnotyetbeen *Q%) deliveredtoEPA.Therearenorelatedpublicationsatthistime. *:&* 7.ArethereareasofNCthathavebeenidentifiedasbeinghigherriskforenvironmental , (, exposuresforchildren?TherewasastudyinJohnstonCountythatindicatedarelativelyhigh -(- prevalenceofADHD,butisthisahighriskareaintermsofcontaminants?  EPAisnotawareofstudiesthatspecificallyidentifycertainNCgeographicareaswithhighrisk  forenvironmentalexposures. k 8.WhiletheRFIPappearstoconcentrateprimarilyonADHD,anditiscertainlypossibletodo & v earlyscreeningforADHD,itwouldalsobepossibletodosomeearlyscreeningforother  _ neurodevelopmentaldisordersinschool,suchaslearningdisordersormentalretardation,  H languagedelays,etc.inyoungerchildren.Earlyidentificationofthesechildrenbeforetheyreach  1  schoolagewoulddefinitelyassistinearlyinterventionandhopefullyimprovedoutcomes.This    iscertainlysomethingwecouldaddtothestudy,unlessthefundingagencywouldliketofocus   solelyonADHD.   ADHDistheprimaryfocusofthisresearch.Otherneurodevelopmentaldisordersareofinterest n  inaddition(but,notinplaceofADHD). W  Ѐ @ 9.Whatisthemechanismformonitoringthechildren'sbodyloadofvariouschemicalsand b metals?Isthissomethingwewouldhavetodoourselves,oristhispartofthecooperative K agreementthatyouallwoulddothis?Isthereaspecificlistofchemicalsandmetalsthatyouare 4 examining?  Thecurrentprojectdoesnotincludebiologicalmonitoring.  10.WillitbeofinteresttoDukeUniversityresearchersthatwehavedevelopedapredictive Z indicatorofexposuretoheavymetalsthatwouldpermitscreeningofyoungchildrentodevelop C interventionsofdamagingenvironmentalfactors? ,| ExposuretoheavymetalsisbeyondthescopeofthecurrentEPArequestforproposals.Wedo N notknowwhatwouldbeofinteresttoDukeUniversityresearchers.  7 11.Isourunderstandingthatthetotalof$120,000forthreeyearsisdirectandindirectcostsuch #" thatourresearchbudgetwillbeapproximately$26,000/yearforthreeyears? $# Thetotalbudgetis$120,000forthreeyears.Theexactresearchbudgetwillbedeterminedbyan ]&!% institution'spolicyonoverheadcosts. F'"& 12.Canspecialtissuesamplesbeobtainedretrospectivelyfromthestudygroup? *Q%) EPAhasnoaccesstothestudygroup. +#'+  -(- 13.WhatistheSES,age,gender,ethnicity,demographicdataofthestudy  population?  EPAdoesnothavethisinformation. k 14.Willtheproposedinterventionsbepsychological/behavioral,psychiatricorpharmacological & v innature?  _ Thisisnotknownatthistime.  1  15.WhatarethepsychometricorbehavioralcriteriaofADHDusedinclassificationofthe   subjects?AretheADHDsubjectssubclassifiedintomorethan2typesoristheresufficientdata   orinteresttosubclassifybeyondthetwo(ADD&HD)types? n  ThisinformationisnotcurrentlyavailabletoEPA. @ 16.HavethesubjectsbeentestedbyfunctionalMRIorPETorotherimagingtechniques? K EPAdoesnothaveanyinformationonthistopic.  17.Aretheregeneticorgenotypedataonthesesubjects?  NotthatEPAisawareof. Z 18.Aretherebirthingdata,alcoholuse,lifecoursedataavailableforthemomsandsubjects? e EPAdoesnothavesuchinformationatthistime.  7 19.IsthisanextensionofresearchdoneatDukethatislikelytoberestrictedtothatsample,and #" setting(essentiallybythoseresearchers)? $# <&!t% No,thegoalofthisprojectistoextendthedatabasebeyondtheinitialsample. <&!$ '=#%'u"20.MaywehaveaccesstothepreviousDukeresearchcitedintheRequestforInitialProposal? (&$& *%)%EPAisnotinpossessionofthedatacollectedbyDukeUniversityresearchersatthistime. *%' 8,'p+&21.Doesitseemfeasibleforthisstudytouserecordswewouldhaveavailableherewhich !-q() wouldincludechildrenidentifiedforschoolservicesbasedonADHDourentirestudent  populationis+96,000?  JEPAhasnowaytodeterminethefeasibilityofthisapproachbasedontheinformationprovided.