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Toxicity Assessment Division
Toxicity Assement Division
The Toxicity Assessment Division addresses toxicological mechanisms and responses for target organ systems using multiple strategies related to
- chemical screening and prioritization including assessing in vivo predictive value of in vitro tests and test methods development and interpretation,
- chemical-specific and mixtures toxicity assessment, including hazard identification/dose-response characterization,
- development/use of animal models of disease, and
- evaluation of specific assumptions/hypotheses generated by systems biology models in collaboration with the Integrative Systems Biology Division.
- NEUROTOXICOLOGY BRANCH
The Neurotoxicology Branch provides expertise for the conduct of research related to the impact of environmental chemicals on the nervous system using measures of function (e.g., physiological, behavioral). The emphasis will be on the determination of the onset, progression, duration and reveribility of neurotoxic injury.
- REPRODUCTIVE TOXICOLOGY BRANCH
The Reproductive Toxicology Branch provides expertise for the conduct of research related to the impact of environmental chemical on the reproductive competence in both males and females and subsequent generations. The emphasis will be gametogenesis and gamete function.
- DEVELOPMENTAL TOXICOLOGY BRANCH
The Developmental Toxicology Branch provides expertise for the conduct of research related to the impact of environmental chemicals on the developing organism, with a special emphasis on developmental deficits stemming from in utero exposures, including the impact later in life. The emphasis will be on all manifestations of developmental toxicity, including structural malformations, growth retardation, and functional impairment, with linkage to the underlying mechanisms, including differentiation pathways and potential epigenetic modifications.
- ENDOCRINE TOXICOLOGY BRANCH
The Endocrine Toxicology Branch provides expertise for the conduct of research related to the impact of environmental chemicals on the endocrine system, including reproductive, developmental and adult functioning of the hypothalmic pituitary-gonadal, thyroid, and adrenal axes.