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Health and Environmental Effects Research

NTD Research Article Recognized as One of Neurotoxicology's Top 10 Downloaded Articles

A paper published by William Mundy and EPA postdoctoral fellow Nick Radio, both of NHEERL's Neurotoxicology Division (NTD), has attracted extensive attention within the toxicology research community and has been recognized by the journal Neurotoxicology as one of its top 10 most downloaded articles. The paper is titled "Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth," and it reviews the use of in vitro techniques suitable for detecting and characterizing the effects of xenobiotics on the extension of neurons, a critical process in the developing nervous system. The techniques reviewed in the article have the potential to facilitate the development of high-throughput predictive assays for initial screening of chemicals to prioritize them for further characterization in more complex and labor intensive systems.

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