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PFAA III

Agenda

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June 8-10, 2010
U.S. EPA, Research Triangle Park, NC
Auditorium C-111

June 8, Tuesday

11:00 AM Registration
1:00 - 1:10 PM Introduction – Chris Lau, TAD, NHEERL, ORD
1:10 - 1:20 Welcoming Remarks – Kevin Teichman, ORD
1:20 - 1:30 Charges of Conference – Elaine Francis, US EPA
1:30 - 5:20 PFAAs in the environmentSession Leaders: Andy Lindstrom (US EPA) and Derek Muir (Environment Canada)
1:30 - 2:15          What's new with PFAAs in the environment? – Scott Mabury (University of Toronto)
2:15 - 2:45           NHANES: PFAAs in US general population – Antonia Calafat (CDC)
2:45 - 3:05           Break
3:05 – 3:35           PFAA distribution in source water and their effective treatment technologies – Shuhei Tanaka
          (Kyoto University)
3:35 – 4:05           PFAAs in wildlife worldwide – Robert Letcher (Environment Canada)
4:05 – 5:30           Open Discussion
5:30 - 6:45 Reception in Atrium, and/or Focus Group I meeting in Auditorium Focus Group I: PFAA Analytical Chemistry Group Leaders: Mark Strynar (US EPA), Shoji Nakayama (US EPA), David Ehresman (3M), Mary Kaiser (DuPont)
To discuss issues concerning the analysis of perfluorinated compounds: minimum requirements of quality assurance and quality control that make data acceptable. Topics will include assessment of accuracy and precision of a method, demonstration of data reliability at low quantitation levels, inclusion of method/matrix blanks, blank matrix spike recovery, use of common reference materials or standards for standardization of methods, potential sources of PFC contamination, and interlaboratory precision. In addition, other issues such as strengths and pitfalls of new analytical techniques (TOF/MS, ion chromatography, total fluorine measurement), ability to analyze a growing number of perfluorinated compounds (on-line SPE, high though-put), modification of analytical equipment for the application to PFC analysis (trap column, removal of LC components) will be addressed.
7:00 Dinner I (optional) at local restaurant

June 9, Wednesday

7:45 - 8:20 AM Light breakfast and coffee
8:20 - 8:30 House-keeping – Lau
8:30 - noon PFAA exposureSession Leaders: Laurence Libelo (US EPA) and Kerry Dearfield (USDA)
8:30 – 8:50      PFAAs in various environmental media – Mark Strynar (US EPA)
8:50 – 9:10      Environmental-Fate Patterns for PFAAs and their Precursors – John Washington (US EPA)
9:10 – 9:30      PFCs in Consumer Articles -- Monitoring the Market Trends – Heidi Hubbard (US EPA)
9:30 – 9:50      Break
9:50 – 10:10      PFAAs in waste water treatment plants and sludge – James Kelly (Minnesota Department of Health)
10:10 – 10:30      PFAA exposure to farm cattle – Kerry Dearfield (USDA)
10:30 – 10:50      PFAAs in food and migration from food and packaging – Tim Begley (FDA)
10:50 – 12:00      Open Discussion
Noon - 1:45 PM Poster Session I in Atrium – Environmental PFAAs and Exposure
(boxed lunch provided)
1:45 - 5:30 PFAA epidemiologySession Leaders: Andrea Pfahles-Hutchens (US EPA) and Geary Olsen (3M)
1:45 – 2:00       A brief overview of PFAA epidemiology – Geary Olsen (3M)
2:00 – 2:25       The C8 Science Panel Program and findings from cross sectional analyses of C8 and clinical
      markers in the Mid-Ohio Valley population
– Tony Fletcher (London School of Hygiene and
      Tropical Medicine)
2:25 – 2:45       Retrospective Exposure Analysis and Predicted Serum Concentrations of PFOA in the Ohio River
      Valley
– P. Barry Ryan (Emory University)
2:45 – 3:00       Open Discussion
3:00 – 3:20       Break
3:20 – 3:40       PFAAs and C8 study with Type II diabetes, uric acid, and lipids – Kyle Steenland (Emory University)
3:40 – 4:00       PFOA And Heart Disease: Epidemiologic Studies of Occupationally Exposed Populations – J. Morel Symons
      (DuPont)
4:00 – 4:25       Open Discussion on toxicological findings vs. epidemiological reports
4:25 – 4:45      PFAAs and reproductive/developmental endpoints, pregnancy outcomes in C8 and other
     community health studies, methodological considerations and future research
– Cheryl Stein
      (Mount Sinai School of Medicine)
4:45 – 5:05       PFAAs and pregnancy outcomes in general population studies, methodological considerations,
      physiology of pregnancy considerations and future research
– Matthew Longnecker (NIEHS)
5:05 – 5:30       Open Discussion
5:30 - 6:45 Social Hour in Atrium, and/or Focus Group II meeting in Auditorium Focus Group II: PFAA Issues Among Governmental Agencies – Group Leaders: Andy Lindstrom (US EPA), Tony Krasnic (US EPA), Gail Mitchell (US EPA), Graham White (Health Canada) To provide an informal venue for networking among risk assessors and other specialists from various regulatory agencies in US (Regions, States, local) and other countries concerning issues they currently face with PFAAs. Participants are invited to share their experience, questions and research needs relating to: PFAA sources, presence in environmental media, transport between and within media, relationships between various media (e.g. soil to water, surface water to drinking water); organizing environmental monitoring surveys; laboratory analysis options; commercial analytical services; development of toxicological end points for regulation and remediation, remediation approaches, health advisory levels; organizing comprehensive management policies; and emerging issues of interest.
7:00 Dinner II (optional) at local restaurant

June 10, Thursday

7:45 - 8:20 AM Light breakfast and coffee
8:20 - 8:30 House-keeping – Lau
8:30 - Noon PFAA toxicitiesSession Leaders: Jennifer Seed (US EPA) and John Butenhoff (3M)
8:30 – 9:00      An overview of PFAA pharmacokinetics – Harvey Clewell (Hamner Institute)
9:00 – 9:30      Organic anion transporters and PFAA tissue distribution – Bruno Hagenbuch (Univeristy of Kansas)
9:30 – 9:50      Break
9:50 – 10:20      An overview of PFAA toxicity – John Butenhoff (3M)
10:20 – 10:50      PFAA ecotoxicity – John Newsted (Michigan Sate University)
10:50 – 12:00      Open Discussion
Noon - 1:45 PM      Poster Session II in Atrium – PFAA Toxicity, Modes of Action and Epidemiology
      (boxed lunch provided)
2:00 - 5:15 Nuclear receptor involvement in PFAA actions – Session Leaders: Chris Corton (US EPA), Cliff Elcombe (CXR Biosciences)
1:45 – 2:00      A brief overview of PFAA modes of action – Chris Corton (US EPA)
2:00 – 2:30      PPAR involvement in PFAA development toxicity – Barbara Abbott (US EPA)
2:30 – 3:00      Nuclear receptor involvement in PFAA-induced metabolic changes – Mitch Rosen (US EPA)
3:00 – 3:20      Break
3:20 – 3:50      PPAR involvement in PFAA immunotoxicity – Jaime DeWitt (East Carolina University)
3:50 – 5:15      Open Discussion on PFAA toxicity and Modes of action, and their relevance to
      epidemiological findings
5:15 - 5:30 Closing remarks – Elaine Francis (US EPA)
5:30 Conference adjourned

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