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PARIS III - Solvent Substitution Software Tool
(Program for Assisting the Replacement of Industrial Solvents)

Solvent Substitution Software Tool, PARIS III, is a desktop/laptop application that allows users to find mixtures of solvents with specific physical and chemical properties, but also have relatively low environmental impacts. The purpose of this software is to help users find replacements for solvent mixtures that are currently being used in industrial processes, but have dangerous environmental side effects. It is also intended that this software be used to find solvents with less environmental impact when designing new industrial processes, and be used to find more benign solvents that can be added to harmful solvents favored by industry to help reduce the overall impact of their environmentally harmful processes.

These replacement solvent mixtures found may be used by companies interested in reducing the impact on the environment that their industrial processes have. The individuals finding these replacements for the interested companies might be:

  • solvent technicians
  • solvent engineers
  • environmental engineers
  • environmental consultants

The theoretical basis for the PARIS III program is the observation that the properties governing solvent behavior are universal, and that the performance of each solvent is quantified by coefficients representing various physical and chemical properties (e.g., viscosity, diffusivity, activity coefficients, etc.). The solvent's features used by PARIS III include dynamic and equilibrium properties, environmental behavior (air index and environmental index), and performance and safety requirements.

By applying this representation to solvent design, PARIS III can rank alternative solvents by choosing those solvents that come as close as possible to the coefficients of the original solvent. A ranked list of replacement solvents can be created within minutes. PARIS III provides a cost-effective approach to pollution prevention because users do not have to change equipment or modify their chemical processes in order to adopt safer, "greener" solvents.

Additional Information

The PARIS III solvent substitution software can be used with Windows XP, Windows 7.0 32-bit and 64-bit, UNIX, and MacOS operating systems.

To Install PARIS III on Your Computer:
  1. Download the latest official release of PARIS III for your computer
  2. If your browser offers the option to run the setup program then do so.
  3. Otherwise have your browser display its list of recent downloads and select the setup file to run it.
  4. If you have problems installing the calculator contact your system administrator.
To learn more about how to run PARIS III and how to interpret its output:
Progress through the PARIS III User's Guide (PDF) (21 pp, 1.13M) (EPA/600/R-13/277) February 2014



Cabezas, H., P.F. Harten, and M.R. Green, "Designing Greener Solvents," Chemical Engineering, Vol. 107, No. 3, 109 (2000).

Li, M., P.F. Harten, and H. Cabezas, "Experiences in Designing Solvents for the Environment," Industrial and Engineering Chemistry Research, 41, 5867 (2002).

Harten, P.F., and G. Salama, "PARIS II, the Search for Cleaner Solvent Replacements for RCRA Chemicals," CleanTech, Vol. 4, Number 11, 20(2004).


Harten, P.F. "Finding Greener Solvent Mixtures to Replace Solvent Mixtures Used in Manufacturing Processes," 3rd International Congress on Sustainability Science & Engineering (ICOSSE ‘13), Cincinnati OH, August 11-15 (2013).

Harten, P.F. "Program for Assisting the Replacement of Industrial Solvents (PARIS III)," 18th Annual Green Chemistry & Engineering Conference, North Bethesda MD, June 17-19 (2014).

Helpful Resources

PARIS III User's Guide (PDF) (21 pp, 1.13M): Provides Information, Guidance, and Tutorial

PARIS III Video by ACS Green Chemistry Institute Exit EPA Disclaimer



Paul Harten


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