’WPCU “1ń¼ą<6Æ1€«ÜI¬ĻnĢh‰™—Bā¾|£‹nż?ŗŲÖµ‹1Ą{åpĮq»UBu„{Sų ]Ąé*Ē’L’'Ź;$x&(v?XwGjatĘtI˜8,\Å­YMg$dxÄG¦…ÖĢÅŪČXP?ļF‚FĮÊ޾²®č+ y 2ōzeä÷”KLØĮ#Öš ­ėaybnl`–‹¾z7 Š¢ĄĢ…„Ų›¹Ģ‚ÕŪÕŪŁł] qnEøøp¶{ņČŪ°Ń@]¦G•$%B^0įoYĮ‰®ü‚ŪĖq)”•ÉÜĀŃÆōĆæg - 5ą¤Ÿ57‹õŪ‹,LŻLYō$Qų|]Tė]ōM}ß>J»²šDSUkeŽČp6ÆmZČŲ+A:ØOŻčHł”¼bz?¹×øņķ†7“ö Œõ@]ē­Õ0źU9 UĻĆ q Ķ…ä±Ģ–až- Ń=ޚ¬@†ŻĢ ŹÄ£³=,xžŠK'¼ĆjŠ»€P§ē!ČWi«œ ųcsĶī–wŪi‹oŽ) —ÓH ųŲqĒE=²ö§VÜ詚Yš4°7Į6É#—`Rš3Wk6g™ ^cōZ]ū Ś8ruiÓ/×mfi;Ņ%}6#ĮŅUF“ %Ł 0(ßw4 N....^ 0< m>˜\\DCRROAM\HPOD3_RRB71232_HPLJ5SI.OAM.OARM.RR.HQ.EPAČČ,,,,ČČ0<L4Ä 9Z ‹.Courier New Regularō($””.‚¦83|x³­¶8s ’U‹’ĄĄĄŻ ƒ!ŻŻ  ŻŌ_ŌSTATEMENT€OF€WORKŠ ° ŠĢExposure€Assessments€for€Toxic€SubstancesŠ ` ŠĢBACKGROUNDŠ pĄ ŠĢą  ąThe€purpose€of€this€requirement€is€to€provide€for€the€performance€ofŠ Š  Šexposure€assessments,€utilizing€existing€procedures,€and€for€the€developmentŠ € Š Šof€relevant€information€necessary€for€EPA€to€develop€new€exposure€assessmentŠ 0 € Šprocedures€in€order€to€fulfill€the€requirements€of€the€Toxic€Substance€ControlŠ ą 0  ŠAct€(Ō_ŌTSCAŌ_Ō),€the€Pollution€Prevention€Act,€and€any€Executive€Order€or€otherŠ  ą  Šlegislative€requirements€made€of€the€Office€of€Pollution€Prevention€and€Ō_ŌToxicsŌ_ŌŠ @   Š(Ō_ŌOPPTŌ_Ō).€€This€requirement€also€provides€support€for€the€performance€of€Š š @  Šexposure€assessments€and€support€for€the€development€of€new€exposureŠ   š  Šassessment€procedures€to€other€Agency€offices€under€other€statutes.€€SimplyŠ P   Šstated,€an€exposure€assessment€is€the€combination€of€data€on€the€source,Š P  Šlocation,€and€characteristics€of€the€chemical€or€biological€agent€withŠ °  Šinformation€on€the€location€and€habits€of€populations.€€An€exposure€assessmentŠ `°  Šdeveloped€to€support€Ō_ŌOPPTŌ_Ō€activities€may€range€from€a€streamlined,€integratedŠ `  Šprocess€for€ranking€and€prioritizing€chemical€and€biological€agents€on€theŠ Ą  Šbasis€of€relative€risk€to€a€very€comprehensive,€complex€and€detailed€analysis.€Š pĄ  ŠIt€may€include€the€development€and€refinement€of€models€which€are€then€used€toŠ  p Špredict€exposure€of€defined€populations€to€a€variety€of€chemicals.€€It€mayŠ Š  Šrequire€monitoring€studies€to€collect€much-needed€field€data€to€defineŠ €Š Šexposure€with€more€certainty.€€It€involves€the€constant€study€and€search€forŠ 0€ Šinformation€on€the€fate€and€transport€properties€of€chemicals€and€theirŠ ą0 Šphysical,€chemical€and€biological€properties.€€Š ą ŠĢOBJECTIVESŠ š@ ŠĢą  ąThe€contractor€shall€submit€a€quality€assurance€project€plan€to€EPA€forŠ P  Šapproval€for€any€work€assignments€involving€environmental€activities.Š P ŠĢ(A)ą  ąWhen€exposure€assessments€are€developed,€EPA€and/or€Ō_ŌOPPTŌ_Ō€exposure€andŠ `°! Šrisk€assessment€policies€and€practices€must€be€followed,€and€the€assessmentŠ `" Šmust€be€tailored€to€the€particular€needs€of€the€EPA.€€The€results€of€theŠ Ą# Šassessment,€including€all€assumptions€made€and€limitations€of€the€assessment,Š pĄ$ Šreferences€used,€populations€and€exposure€scenarios€included€within€theŠ  p% Šassessment,€and€recommendations€based€on€the€assessment€must€be€clearlyŠ Š & Šcommunicated€within€the€report.€€To€fulfill€this€requirement,€the€contractorŠ €Š' Šshall:€develop€the€assessment€in€accordance€with€established€exposure€and€riskŠ 0 €( Šassessment€methods€and€peer€review€procedures,€provide€information€andŠ ą 0) Šdocumentation€to€support€the€assessment,€and€tailor€the€assessment€to€theŠ !ą* Šspecific€needs€of€the€EPA.€€The€assessment€shall€include€reasonableŠ @"+ Šassumptions€and€be€based€on€scientifically€sound€methods€which€shall€beŠ š"@, Šconsistent€with€similar€assessments€where€possible€and€shall€be€based€onŠ  #š- Šcurrent€and€reliable€data€and€information.€€The€report€shall€be€developedŠ P$ . Šusing€plain€language€where€possible.Š %P / ŠĢB)ą  ąWhen€models€are€used€to€predict€exposure,€assumptions€are€often€neededŠ `&°!1 Što€define€the€scenario€to€be€modeled€and€data€are€needed€to€characterize€theŠ '`"2 Šscenario€and€the€chemical€or€biological€agent€of€interest.€€€The€more€credibleŠ Ą'#3 Šthe€assumptions€and€the€more€complete€and€current€the€supporting€data,€theŠ p(Ą#4 Šbetter€the€exposure€assessment.€€Consequently,€to€fulfill€this€requirement€theŠ  )p$5 Šcontractor€shall:€€provide€information€to€the€Government€sufficient€to€supportŠ Š) %6 Šthese€modeling€exercises,€and€shall€refine€and€update€analytical€toolsŠ €*Š%7 Šnecessary€to€accomplish€this€objective.€€Electronic€deliverables€shall€beŠ 0+€&8 ŠSection€508€compliant€unless€EPA€determines€that€Section€508€compliance€willŠ ą+0'9 Šcreate€an€undue€burden€on€the€Agency.€€The€requirement€for€compliance€will€beŠ ,ą': Šdetermined€through€the€standard€work€assignment€process.Š @-(; ŠŠ š-@)< ŠŌ_Ō(C)ą  ąWhen€monitoring€or€laboratory€studies€are€required,€the€contractor€shallŠ ° Šfollow€EPA€and/or€OPPT€procedures€to€develop€a€sampling€plan.€€€The€contractorŠ `° Šshall€make€all€necessary€arrangements€to€assure€the€success€of€the€monitoringŠ ` Šstudy.€Š Ą ŠĢSCOPE€OF€WORKŠ  p ŠĢą  ąThe€contractor€shall€provide€information€to€the€Government€sufficient€toŠ € Š Šsupport€the€development€of€exposure€assessments€for€situations€that€are€notŠ 0 € Šnecessarily€specific€to€any€one€chemical.€€This€involves€the€development€ofŠ ą 0  Šinnovative€and€creative€procedures€to€assess€exposure€to€clusters€ofŠ  ą  Šchemicals,€chemicals€contained€in€marketable€products€and€geneticallyŠ @   Šengineered€microorganisms€defined€to€be€chemicals€for€the€purposes€of€theŠ š @  ŠToxic€Substance€Control€Act.€€Further,€the€contractor€shall€provideŠ   š  Šassessments€either€for€existing€chemicals€where€the€values€obtained€areŠ P   Šestimates€of€actual€exposure€or€for€new€chemicals€(or€projected€changes€inŠ P  Šproduction/use/disposal€patterns€of€existing€chemicals),€where€the€valuesŠ °  Šobtained€are€estimates€of€potential€future€exposures.€€€In€support€ofŠ `°  Šassessments,€the€contractor€shall€prepare€technical€materials,€€provideŠ `  Štechnical€representation,€and€compile€technical€proceedings€for€meetings€andŠ Ą  Šconferences.Š pĄ  ŠĢDELINEATION€OF€CONTRACTOR€TASKSŠ Š  ŠĢą  ąThe€contractor€shall€perform€work€on€a€work€assignment€basis.Š 0€ ŠĢTASK€1.ą ` ąThe€contractor€shall€complete€work€assignments€requiringŠ ą Šidentification€of€the€human€and€nonhuman€populations€exposed€to€chemicals,Š @ Šproducts€containing€chemicals,€genetically€engineered€microorganisms€and€microŠ š@ Šbiocides€under€scrutiny€by€the€Office€of€Prevention,€Pesticides€and€ToxicŠ  š ŠSubstances€and€shall€describe€and€quantify€these€exposures.€€This€exposureŠ P  Šassessment€report€shall€include€an€evaluation€of€the€chemical's€distributionŠ P Šin€the€environment€through€application€of€materials€balance€techniques€(e.g.,Š °  Štracking€the€chemical€through€production,€use,€transportation,€spills€andŠ `°! Šemissions€from€point€and€nonpoint€sources).€€€In€assessing€exposure,€theŠ `" Šcontractor€shall€for€each€chemical€or€predefined€cluster€of€chemicals,Š Ą# Šidentify€its€environmental€transport€and€transformation€(fate);€its€actual€orŠ pĄ$ Špotential€presences€in€air,€land,€water,€sediment,€food,€drinking€water,Š  p% Šsludge,€marketable€products€or€indoor€air.€€The€contractor€shall€useŠ Š & Šmonitoring€data€or€techniques€or€prediction€tools€to€accomplish€this.€€€TheŠ €Š' Šcontractor€shall€estimate€the€number€and€distribution€of€individualsŠ 0 €( Špotentially€or€actually€exposed.€€Finally,€the€contractor€shall€submit€aŠ ą 0) Šreport€that€details€all€data,€assumptions€and€results.€€Š !ą* ŠĢTASK€2.ą ` ąThe€contractor€shall€conduct€literature€searches,€compile€andŠ š"@, Šassimilate€research€findings€into€current€exposure€assessment€€methodologies,Š  #š- Šcollect€information€necessary€to€develop€scenarios€by€which€EPA€will€assessŠ P$ . Šexposure€(for€the€various€types€of€exposure€assessments€conducted€by€theŠ %P / ŠAgency),€collect€data€through€monitoring€or€laboratory€studies€and€conductŠ °%!0 Šmodeling€activities,€resulting€in€a€report€which€EPA€will€utilize€to€conductŠ `&°!1 Šexposure€assessments.€€The€contractor€shall€develop€all€or€part€of€theŠ '`"2 Šfollowing€information:€pertinent€physical,€chemical,€toxicological,€biologicalŠ Ą'#3 Šand€fate€properties€of€chemicals;€the€environmental€materials€balance€ofŠ p(Ą#4 Šchemicals;€monitoring€data;€laboratory€data;€estimates€of€concentrations€ofŠ  )p$5 Šchemicals€in€air,€land,€water,€ground€water,€sediment,€food,€drinking€water,Š Š) %6 Šsludge,€marketable€products€or€indoor€air;€environmental€pathways€forŠ €*Š%7 Šchemical;€population€studies;€exposure€factors€to€be€used€in€calculatingŠ 0+€&8 Šexposures,€especially€for€those€populations€that€may€have€exposures€differentŠ ą+0'9 Šfrom€those€of€the€general€population;€human€activity€patterns;€estimates€ofŠ ,ą': Šchemical€concentrations€discharged€from€industrial€facilities,€publicly-ownedŠ @-(; Štreatment€works,€households,€consumer€products,€building€materials,€hazardousŠ š-@)< Šwaste€sites€and€nonpoint€sources€of€pollution.Š ° ŠĢTASK€3.ą ` ąThe€contractor€shall€identify,€compile€and€develop€case€studiesŠ ` Šand€informational€materials€illustrating€how€actions€taken€by€EPA€and€othersŠ Ą Šhave€reduced€exposure€to€chemicals€or€clusters€of€chemicals.€€In€particular,Š pĄ Šthese€case€studies€shall€reflect€pollution€prevention€activities€and€thoseŠ  p Šmade€within€the€framework€of€the€Design€for€the€Environment€program.€€Š Š  ŠĢTASK€4.ą ` ąIn€support€of€tasks€1,€2,€and€3,€€the€contractor€shall€prepareŠ 0 € Štechnical€materials,€shall€provide€technical€representation,€and€shall€compileŠ ą 0  Štechnical€proceedings€for€meetings€and€conferences,€as€needed.€€€The€requiredŠ  ą  Šservices€shall€be€ordered€through€the€standard€work€assignment€process.€€WhenŠ @   Šattending€meetings€or€conferences,€contractor€employees€shall€be€required€toŠ š @  Šwear€name€tags€which€clearly€identify€their€names€and€the€companies€theyŠ   š  Šrepresent.€€They€shall€also€verbally€identify€themselves€and€the€companiesŠ P   Šthey€represent€before€meetings€begin.Š P  ŠĢĢą  ąą ` ąą ø ąą  ąą h ą€