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Muscodor albus QST 20799 (006503) Fact Sheet

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Issued: 09/17/05

On This Page

  1. Description of the Active Ingredient
  2. Use Sites, Target Pests, and Application Methods
  3. Assessing Risks to Human Health
  4. Assessing Risks to the Environment
  5. Regulatory Information
  6. Registrant Information
  7. Additional Contact Information

Summary

Muscodor albus QST 20799 is a naturally-occurring fungus which was originally isolated from the bark of a cinnamon tree in Honduras. It was imported into the US with appropriate permits issued by the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Services (APHIS). It grows as a white sterile mycelium and does not produce asexual or sexual spores or other reproductive structures such as chlamydospores or sclerotia. When hydrated, M. albus Strain QST 20799 produces a number of volatiles, mainly alcohols, acids, and esters, that are claimed to inhibit and kill certain bacteria and other organisms that cause soil-borne and post harvest diseases. It is proposed as a methyl bromide replacement for seed, propagule, soil and post harvest treatments of all food or feed commodities, as well as ornamentals and cut flowers. Products containing this active ingredient can be used in the field, greenhouses, and warehouses.

  1. Description of the Active Ingredient

    2. Muscodor albus QST 20799 is fungus which does not survive after it uses up its food sources, because it does not produce reproductive bodies. The volatiles the pesticide products produce after rehydration occur naturally as flavors and fragrances in food and beverages. In addition, soil and other application methods are not likely to leave residues of the pesticide on treated food or feed. This pesticide, which disappears rapidly, controls bacteria, fungi and nematodes which cause diseases in the roots of plants, or on seeds, propagules, food, feed and cut flowers after they are harvested.

  2. Use Sites, Target Pests, and Application Methods

    3. - Whether or not a substance poses a risk to humans or other organisms depends on two factors: how toxic the substance is, and how much of it an organism is exposed to. Therefore, the EPA considers both toxicity and exposure data in determining whether to approve a pesticide for use.

  3. Assessing Risks to Human Health

    4. No harmful effects are likely to occur to workers or the public from use of Muscodor albus on crops . Laboratory studies indicate that the active ingredient is not toxic or infective following lung, oral, eye or skin exposure in rats. In these studies, the microbe did not survive in rat tissues, indicating that the microbe is unlikely to cause infections in mammals. During laboratory research and field trials, no workers reported adverse effects.

    Human exposure to Muscodor albus QST 20799 used as a pesticide active ingredient will be minimal with no expected adverse effects. Dietary exposure to the microbe and its volatiles is not expected, because residues of neither remain on treated food or feed. Even if the pesticides remain on the food, the studies done with rats indicate that there is a reasonable certainty that they will not harm mammals. When this granular pesticide product is applied to soils of commercial fields, its low potential for drift minimizes residential and worker exposure. Exposure to workers is further minimized because they are required to wear appropriate personal protective equipment (PPE).

  4. Assessing Risks to the Environment

    5. No harmful environmental effects are expected from pesticidal uses of this microbial active ingredient. Published literature and submitted studies indicate that the active ingredient will not cause adverse effects to mammals, birds, honeybees, other non-target insects, or plants. Studies show that Muscodor albus QST 20799 does not produce spores, and does not survive in the environment after it uses up its food sources. The volatile compounds also dissipate rapidly. Thus, runoff is not expected. Moreover, the pesticide product will not be applied to bodies of water, minimizing adverse effects to aquatic organisms.

    Endangered Species: There is no evidence of toxicity or pathogenicity for this active ingredient in the literature or in submitted studies on mammals, birds, insects, aquatic organisms, and plants. Consequently, Muscodor albus QST 20799 is not expected to harm endangered or threatened species.

  5. Regulatory Information

    6. Between July 15, 2003 and January 13, 2004 , the registrant applied for registration of four new products containing Muscodor albus QST 20799 as the active ingredient. On September, 2005 EPA registered the concentrated technical product QST 20799 (EPA Registration # 69592-14), which is used for the manufacture of three end-use products, Arabesque J (EPA Reg. No. 69592-15), Andante J (EPA Reg. No. 69592-17), and Glissade J (EPA Reg. No. 69592-18). The registrant must produce the standard 5 batch analyses required to show that quality control is adequate during production. These registrations will expire in March, 2008 (30 months after registration) unless the registrant meets certain conditions. These conditions require the registrant to submit data on 1) inhalation of the volatiles to confirm that it will not harm workers, and 2) the storage stability data which supports the claim of one year stability in storage. After reviewing the submitted information, EPA will decide whether to register these products without special conditions.

  6. Registrant Information

    7. AgraQuest, Inc.
    1530 Drew Avenue
    Davis, CA 95616

  7. Additional Contact Information

    8. Ombudsman, Biopesticides and Pollution Prevention Division (7511P)
    Office of Pesticide Programs
    Environmental Protection Agency
    1200 Pennsylvania Avenue, NW
    Washington, D.C. 20460

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