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EPA Solicits Public Review and Comment on Draft Information Collection Request for Tier 2 Data for Pesticide Chemicals for Endocrine Disruptor Screening

For Release: June 24, 2013

The U.S. Environmental Protection Agency (EPA) is initiating a 60-day public review and comment on a draft Information Collection Request (ICR) for collecting Tier 2 test data for a subset of pesticides (referred to by the Agency as List 1 chemicals) that have the potential to interact with the endocrine system. The ICR estimates the paperwork burden imposed by requesting data on these chemicals.

The EPA’s Endocrine Disruptor Screening Program (EDSP) consists of a two-tiered approach to screen and test chemicals for endocrine disrupting effects. Tier 1 screening tests identify substances that have the potential to interact with the estrogen, androgen, or thyroid hormone systems. Substances identified as having the potential to interact with these systems may require additional Tier 2 tests which identify any adverse endocrine-related effects caused by the substance and establish a quantitative relationship between the dose and that endocrine effect.

The ICR request is an initial step in a multi-step process that will culminate in the issuance of test orders for a subset of the chemicals that have undergone Tier 1 screening. Tier 2 test order requests would begin only after: 1) the agency has determined which chemicals warrant additional Tier 2 data, 2) the EPA receives and considers public comments on the draft ICR, 3) EPA submits a final ICR to OMB, providing a subsequent 30-day public comment period, and 4) OMB reviews the ICR.

Last week, in a separate activity, the EPA initiated a final 30-day public review and comment on an ICR for collecting Tier 1 data for a second list of chemicals (referred to as List 2 chemicals) to be screened for the potential to interact with the endocrine system.

The EPA is committed to more fully understanding the potential risks of chemicals that may affect endocrine systems by screening pesticides and other chemicals for their potential effects on estrogen, androgen and thyroid hormone systems.  In 1996, Congress passed the Food Quality Protection Act and the Safe Drinking Water Act Amendments requiring the EPA to screen pesticide chemicals and drinking water contaminants for their potential to produce effects similar to those produced by the female hormones (estrogen) in humans. The EPA also has authority to screen certain other chemicals to identify other endocrine effects. The Endocrine Disruptor Screening Program (EDSP) also evaluates chemical effects on male hormones (androgens) in the human thyroid system and effects on wildlife.

More information on the Endocrine Disruptor Screening Program: http://www.epa.gov/endo/.

The Agency’s draft ICR for Tier 2 collection activities is available under docket identification number EPA-HQ-OPPT-2013-0171 at http://www.regulations.gov.

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