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Exclamation Mark

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Symbol of exclamation mark in a red diamond-shaped warning borderThis is the symbol that will appear on chemicals with less severe toxicity. Depending on the health hazard, it can mean:

 



This chart summarizes the hazard criteria for the category(s) in each class for the exclamation mark pictogram to appear on a pesticide product label. It also lists the corresponding hazard statement and signal word that will accompany the pictogram. This information is for illustrative purposes only; please consult the official GHS text Exit EPA disclaimer for complete information.  

Hazard Category

Criteria

Hazard Communication Elements

Acute toxicity

4

LD50 between 300 and less than 2000 mg/kg
bodyweight (oral)

LD50 between 1000 and less than 2000 mg/kg
bodyweight (skin/dermal)

LC50 between 2500 and less than 5000 ppm (gas)

LC50 between 10.0 and less than 20.0 (mg/l) (vapour)

LC50 between 1.0 and less than 5.0 (mg/l)
(dust, mist)

Symbol

Symbol of a an exclamation mark will appear on chemicals with less severe toxicity

Signal Word

Warning

Hazard Statement

Harmful if
swallowed (oral)

Harmful in contact with skin(dermal)

Harmful if inhaled (gas, vapour, dust, mist)

Skin
Corrosion/
Irritation

 

2

 

1. For substances and tested mixtures

  • Human experience or data showing reversible damage to the skin following exposure of up to 4 hours;
  • Structure/activity or structure property relationship to a substance or mixture already classified as an irritant;
  • Positive results in a valid and accepted in vitro skin irritation test; or
  • Animal experience or test data that indicate that the substance/mixture causes reversible damage to the skin following exposure of up to 4 hours, mean value of ≥ 2.3 < 4.0 for erythema/eschar or for oedema, or inflammation that persists to the end of the observation period, in 2 of 3 tested animals (Table 3.2.2).

2. If data for a mixture are not available, use bridging principles in 3.2.3.2.

3. If bridging principles do not apply, classify as an irritant if:

(a) For mixtures where substances can be added: the sum of concentrations of corrosive substances in the mixture is ≥ 1% but ≤5%; the sum of the concentrations of irritant substances is > 10%; or the sum of (10 × the concentrations of corrosive ingredients) + (the concentrations of irritant ingredients) is ≥ 10%; or (b) For mixtures where substances cannot be added:≥ 3% (see 3.2.3.3.4).

Symbol

Symbol of a an exclamation mark  will appear on chemicals with less severe toxicity

Signal Word

Warning

Hazard Statement

Causes skin irritation

Serious eye damage/eye irritation

 

2A

1. For substances and tested mixtures

  • Classification as severe skin irritant;
  • Human experience or data showing production of changes in the eye which are fully reversible within 21 days;
  • Structure/activity or structure property relationship to a substance or mixture already classified as an eye irritant;
  • Positive results in a valid and accepted in vitro eye irritation test; or
  • Animal experience or test data that indicate that the substance/mixture produces a positive response in at least 2 of 3 tested animals of: corneal opacity ≥ 1, iritis ≥ 1, or conjunctival edema (chemosis) ≥ 2 (Table 3.3.2).

2. If data for a mixture are not available, use bridging principles in 3.3.3.2.

3. If bridging does not apply, classify as an irritant (2A) if:

(a) For mixtures where substances can be added: the sum of the concentrations of skin and/or eye Category 1 substances in the mixture is ≥ 1% but ≤ 3%; the sum of the concentrations of eye irritant substances is ≥ 10%; or the sum of (10 × the concentrations of skin and/or eye category 1 substances) + (the concentrations of eye irritants) is ≥ 10%; (b) For mixtures where substances cannot be added: the sum of the concentrations of eye irritant ingredients is 3% (see 3.3.3.3.4).

Symbol

Symbol of a an exclamation mark will appear on chemicals with less severe toxicity

Signal Word

Warning

Hazard Statement

Causes Serious Eye Irritation

Skin sensitizer

1

1. For substances and tested mixtures

  • If there is evidence in humans that the individual substance can induce sensitization by skin contact in a substantial number of persons, or
  • Where there are positive results from an appropriate animal test.

2. If the mixture meets the criteria set forth in the “Bridging Principles” through one of the following:

(a) Dilution;
(b) Batching;
(c) Substantially similar mixture.

3. If bridging principles do not apply, classify if any
individual skin sensitizer in the mixture has a
concentration of: ≥ 1.0% Solid/Liquid/Gas

Symbol

Symbol of a an exclamation mark  will appear on chemicals with less severe toxicity

Signal Word

Warning

Hazard Statement

May cause allergic skin reaction

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