Note: This information is provided for reference purposes only.
Although the information provided here was accurate and current
when first created, it is now outdated.
Staff Paper #22
Issues and Decision Points for OP Tolerance Reassessment
Discussion points pertaining to the Tolerance
Reassessment Proccess that are being presented for discussion by the TRAC
Workgroup #2 on 7/27/98.
1. Mitigation of Individual OP Risk Endpoints
How much mitigation of individual OP risk concerns is appropriate before
the EPA begins the cumulative risk assessment? -- Should all risk concerns
be fully mitigated on an individual OP basis before proceeding with the
-- Should individual risk mitigation begin and continue parallel to cumulative
assessment and related risk management -- Should only risks of greatest concern
be fully mitigated first? -- Should risks only be mitigated to the point
where a cumulative risk assessment methodology and technical capability are
2. Cumulative Risk Assessment
When is it appropriate or desirable for the EPA to conduct a full cumulative
risk assessment that includes food, water, and residential contributions
to dietary risk?
Should the full cumulative risk assessment be reached though a tiered process,
beginning with a food only cumulative risk assessment?
3. Data Refinement
At what point(s) in the process should the Agency allow for additional
data/information generation or data submission?
What data are appropriate to generate or submit in light of the FQPA timeframes,
current risk assessment methodologies and evaluation tools?
4. Tolerance Reassessment
Can some tolerances be determined acceptable at an early stage based on a
very small contribution to risk plus high value
-- Should it be a factor if the individual related OP has been managed to
an acceptable risk level
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updated July 24, 1998