United States Environmental Protection Agency Office of Pesticide Programs

Docket Index for
The Use of Data on Cholinesterase Inhibition for Risk Assessments
Docket Index Number OPP-00560A

Information provided for informational purposes only

Note: This information is provided for reference purposes only. Although the information provided here was accurate and current when first created, it is now outdated.

Title:
Author:
Date:
(References for Policy)
Check Sample: Cholinesterase: Review of Methods
ASCP
1994
Symposium on Computerized Behavioral Testing on Humans in Neurotoxicology Research: Overview of Proceedings
Anger, Otto, Letz
1996
Proceedings of the US EPA Workshop on Cholinesterase Methodologies
Brimijoin
1992
Medical Supervision of Pesticide Workers: Guidelines for Physicians
California Dept. of Health Services
1988
Use of Cholinesterase Inhibition Data in Risk Assessments for Pesticides
California Dept. of Pesticide Regulation
1992
Cholinesterase Literature Review and Comment, Part B
Dementi
1997
Toxic Effects of Pesticides
Ecobichon
1996
A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity
Ellman, Courtney, Andres, Featherstone
1961
A Cholinesterase Testing Program for Pesticide Applicators
Fillmore and Lessenger
1993
Re: "The use of data on Cholinesterase inhibition for risk assessments of organophosphates and carbamate pesticides
Franklin, PMRA
1999
Neurotransmission: The Automatic and Somatic Motor Nervous System, The Pharmacological Basis of Therapeutics
Hoffman, et al
1996
Automated Instrument Analysis of Cholinesterase Activity in Tissues from Carbamate-Treated Animals: A Cautionary Note
Hunter, et al
1997
A Method for Specifically Assaying Acetylcholinesterase Activity in Peripheral Tissues, Toxicological Sciences
Marshall, et al
1999
Common Mechanism of Toxicity: A Case Study of Organophosphorus Pesticides
Mileson, et al
1998
Common Mechanism Toxicity: Evaluation of Carbamate Pesticides
Mileson, et al
1999a
Guidance for the Design and Interpretation of Studies Intended to Characterize Acetylcholinesterase Activity in the Peripheral Nervous System
Mileson, et al
1999b
Recognition and Management of Pesticide Poisonings, 4th Edition
Morgan, et al
1989
Risk Assessment in the Federal Gov: Managing the Process
NRC/NAS
1983
Science and Judgement in Risk Assessment
NRC/NAS
1994
Recognition and Management of Pesticide Poisonings, 5th Edition
Reigart and Roberts
1999
Joint SAB/SAP review of Cholinesterase Inhibition and Its Effects
SAB/SAP
5/23/90
A Set of Scientific Issues Being Considered by the Agency in Connection with Aldicarb and Aldicarb Sulfone
SAB/SAP
11/16/92
Review of the Risk Assessment Forum's Draft Guidance on the Use of Data on Cholinesterase Inhibition in Risk Assessment
SAB/SAP
4/1/93
SAP Meeting Report: A Set of Scientific Issues Being Considered by the Agency Concerning OPP's Cholinesterase Inhibition Policy
SAP
1997
Treatment of Central Nervous System Degenerative Disorders - The Pharmacological Basis of Therapeutics
Standaert and Young
1996
Anticholinesterase Agents - The Pharmacological Basis of Therapeutics
Taylor
1996a
Agents Acting at the Neuromuscular Junction and Automatic gaGanglia - The Pharmacological Basis of Therapeutics
Taylor
1996b
The Cholinesterases: From Genes to Proteins
Taylor and Radic
1994
Discussion Summary of the Colloquium on Cholinesterase Inhibition
US EPA
6/30/88
Proceedings of the US EPA Workshop on Cholinesterase Methodologies
US EPA
3/1/92
Methods of Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry
US EPA
1994
The Use of the Benchmark Dose Approach in Health Risk Assessment
US EPA
2/1/95
Guidelines for Neurotoxicity Risk Assessment
US EPA
1998a
SAB/SAP Notification of Public Advisory Committee Meeting
US EPA
11/23/98
Pesticides: Science Policy Issues Related to FQPA
US EPA
2/5/99
Pesticides: Science Policy Issues Related to FQPA
US EPA
7/8/99
SAP Notice of Public Meeting
US EPA
9/3/99
Draft - A Science Policy on a Common Mechanism of Toxicity: The Carbamate Pesticides and the Grouping of Carbamate with the Organophosphorus Pesticides (64 KB, PDF)
US EPA
1999c
SAB, Notification of Public Advisory Committee Meeting
US EPA
11/25/99
Docket No. OPP-00560, OPP's Science Policy on the Use of Cholinesterase Inhibition for Risk Assessments of Organophosphates and Carbamate Pesticides
JMPR
1999
Principals for the Toxicological Assessment of Pesticide Residues in Food
WHO
1990
Factors in Standardizing Automated Cholinesterase Assays
Wilson, et al
1996
Effects of Hypophysectomy on Acetylcholinesterase and Butyrlcholinesterase in the Rat
Edwards and Brimijoin
1982
A Rapid, Simple Radiometric Assay for Cholinesterase, Suitable for Multiple Determinations
Johnson & Russell
1974
(References for Comment/Response Memo)
Morphogenic Role for Acetylcholinesterase in Axonal Outgrowth during Neural Development
Bigbee, et al
1999
Cholinesterases in Neural Development: New Findings and Toxicologic Implications
Brimijoin and Koenigsberger
1999
Regional Studies of Catecholamines in the Rat Brain
Glowinski and Iverson
1965
Automated Instrument Analysis of Cholinesterase Activity in Tissues from Carbamate-Treated Animals: A Cautionary note
Hunter, et al
1996
A Retrospective Analysis of Twelve Developmental Neurotoxicity
Makris, et al
1998
Other Related Materials
A Method for Specifically Assaying Acetylcholine-Esterase Activity in Peripheral Tissues - Toxicological Sciences
Marshall, et al
1999
Guidance for the Design and Interpretation of Studies Intended to Characterize Acetylcholinesterase Activity in Peripheral Nervous System
Mileson, et al
1999
Recognition and Management of Pesticide Poisonings, 4th Decision
Morgan
1998
A Set of Scientific Issues Being Considered by the Agency to Discuss OPP Policy for Determination of Anticipated Residues of Pesticides in Foods for Use in Chronic Dietary Exposure Assessments
SAP
1997
A Set of Scientific Issues Being Considered by the EPA Regarding: A Retrospective Analysis of Developmental Neurotoxicity Studies
SAP
1999
Developmental Cholinotoxicants: Nicotine and Chlorpyrifos
Slotkin
1999
Proceedings of the US EPA Workshop on Cholinesterase Methodologies
US EPA
1992
SOP for Measuring Cholinesterase in Laboratory Rats and Dogs Exposed to Non-Reversible Cholinesterase Inhibitors
US EPA
1996
SAB/SAP Notification of Public Advisory Committee Meeting
US EPA
11/23/98
Pesticides; Policy Issues Related to FQPA
US EPA
1999a
FIFRA Scientific Advisory Panel Notice of Public Meeting
US EPA
11/15/99
SAB, Notification of Public Advisory Committee Meeting: Environmental Economics Advisory Committee
US EPA
10/25/99
FIFRA Scientific Advisory Panel; Open Meeting
US EPA
9/3/99
Docket No. OPP-00560, OPP's Science Policy on the Use of Cholinesterase Inhibition for Risk Assessments of Organophosphates and Carbamate Pesticides
WHO/JMPR
1999
Principals for the Toxicological Assessment for Pesticide Residues in Food
WHO
1990
Factors in Standardizing Automated Cholinesterase Assays
Wilson, et al
1996
OPP Response to Dissenting Comments on the Cholinesterase Policy (21 KB, PDF)
US EPA
2000
Responses to Public Comments on the Office of Pesticide Programs' Science Policy
US EPA
2000

The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides (140 KB, PDF) (March 22, 2000 draft with comments from Dr. Brian Dementi)

US EPA and
Dementi
2000
Comments from Dr. Brian Dementi (34 KB, PDF) (August 25, 1999)
Dementi
1999
Comments from Brian Dementi to Marcia Mulkey (19 KB, PDF) (September 9, 1999)
Dementi
1999
The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides (128 KB, PDF) (Revised document, dated August 18, 2000)
US EPA
2000

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updated October 16, 2000