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Cumulative Risk Assessment: Developing the Methods - Available Papers and Where They May be Located

Information provided for informational purposes only

Note: This information is provided for reference purposes only. Although the information provided here was accurate and current when first created, it is now outdated.

February 27, 2002

THE BEGINNING

The Food Quality Protection Act (FQPA), which became law in August 1996, requires EPA to consider the cumulative effects to human health that can result from pesticides and other substances that have a common mechanism of toxicity. Through cumulative risk assessment EPA will be able to determine if the risks posed by a group of pesticides that act in the same way in the body meet the current safety standard.

HOW HAS THE CUMULATIVE RISK ASSESSMENT PROCESS COME ABOUT?

The Office of Pesticide Programs has developed a framework for conducting cumulative risk assessments on pesticides. Achieving this framework has required the development of new methods and tools. EPA began with consideration of what constitutes common mechanism of toxicity, then moved on to methods for conducting aggregate exposure and risk assessments, and finally to the cumulative risk assessment process.

A common mechanism of toxicity group consists of chemicals for which scientifically reliable data demonstrate that the same toxic effect occurs in or at the same organ or tissue by essentially the same sequence of major biochemical events.

As part of the individual chemical risk assessment, EPA performs an aggregate risk assessment. The aggregate risk assessment includes consideration of exposures to the pesticide from food, drinking water, and residual/non-occupational sources.


* Science policy documents

** Background documents and reports from the FIFRRA SAP

*** Information on reports by the International Life Sciences Institute Exit EPA disclaimer

**** Model presented by the company developing, not by EPA

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