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May 8, 2015 -- EPA will hold a public meeting to receive comments on the proposed TSCA section 8(a) nano rule. The meeting will be held at EPA headquarters from 9 a.m. - 4 p.m. on June 11, 2015. Learn about how to register to attend the meeting.

May 8, 2015 -- EPA published the direct significant new use rules (SNURs) for 25 chemical substances which were the subject of premanufacture notices (PMNs).

April 9, 2015 -- EPA proposed the modification of the significant new use rules (SNURs) for 24 chemical substances that were the subject of premanufacture notices (PMNs).

March 24, 2015 -- EPA published the revocation of the significant new use rule (SNUR) for two chemical substance identified generically as metal salts of complex inorganic oxyacids, which were the subject of premanufacture notices (PMNs) P-89-576 and P-89-577.

March 6, 2015 -- EPA published the final significant new use rule (SNUR) for the chemical substance Pentane, 1,1,1,2,3,3-hexafluoro-4-(1,1,2,3,3,3-hexafluoropropoxy)- that was the subject of premanufacture notice (PMN) P-07-204.

March 3, 2015 -- EPA published an extension of the comment period for the proposed significant new use rules (SNURs) for 13 chemical substances that were the subject of premanufacture notices (PMNs).

Important Information

WARNING - DO NOT e-mail any Confidential Business Information (CBI) to EPA. EPA's e-mail system is NOT secured to protect CBI.

All new PMNs and SNUNs, as well as support documents (for notices submitted after April 6, 2010), must be provided to EPA via ePMN and CDX.

New Address for PMN Fees

SNUN reminder: When submitting a Significant New Use Notice (SNUN), companies should include a cover letter. Read more information about SNUNs and what the cover letter should include.

Note: Having a Chemical Abstract Services Registry Number (CASRN) for a chemical does not equate to that chemical being listed on the TSCA Inventory.

Speak to a Specialist

The Toxic Substances Control Act Hotline (tsca-hotline@epa.gov) can answer questions about the PMN process or filing a PMN form.
Call (202) 554-1404
Monday to Friday: 8:30 a.m. - 5:00 p.m. EST
FAX (202) 554-5603

Mandated by section 5 of the Toxic Substances Control Act (TSCA), EPA's New Chemicals program helps manage the potential risk to human health and the environment from chemicals new to the marketplace. The program functions as a "gatekeeper" that can identify conditions, up to and including a ban on production, to be placed on the use of a new chemical before it is entered into commerce. Section 5 of TSCA requires anyone who plans to manufacture (including import) a new chemical substance for a non-exempt commercial purpose to provide EPA with notice before initiating the activity. This premanufacture notice, or PMN, must be submitted at least 90 days prior to the manufacture of the chemical.

This Web site provides information on how the PMN process works and on related programs, including the existing chemicals programs under TSCA and the Sustainable Futures Initiative, which shows companies how to use the new chemicals program's computer models to screen PMNs or exemption notices before they submit them to EPA.

Find out more about various parts of the program:

Before the PMN Process Starts The Process Results Related Programs


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