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TSCA Section 8(e) Substantial Risk Notifications and FYI Submissions Received September 2005

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0905-16200A (PDF)
(37 pp, 2.11MB)
Ruthenium, dichloro [(phenylthio) methylene]bis(tricy-clohexylphosphine) 219770-99-7 N Ciba Specialty Chemicals North Corporation Final report of a local lymph node assay in mice.
8EHQ-0905-16201A (PDF)
(126 pp, 8.29MB)
Chemical Confidential N Ciba Specialty Chemicals North Corporation Draft report of an in vitro mouse lymphoma cell forward mutation assay and draft report of an in vitro cell transformation assay in Syrian hamster embryo cells.
8EHQ-0905-16202A (PDF)
(47 pp, 3.56MB)
Diphenylmethane-4,4'-diisocyanate** 9016-87-9 N American Chemistry Council Final report (without Appendix) of a lung sensitization study in rats following topical induction and repeated inhalation challenge dosing.
8EHQ-0905-16203A (PDF)
(2 pp, 151K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16204A (PDF)
(2 pp, 156K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16205A (PDF)
(2 pp, 154K)

Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16206A (PDF)
(2 pp, 153K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16207A (PDF)
(2 pp, 153K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16208A (PDF)
(2 pp, 153K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16209A (PDF)
(2 pp, 154K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16210A (PDF)
(2 pp, 159K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16211A (PDF)
(2 pp, 153K)
Z-9-Dodecanol*** 35148-18-6 N BASF Corporation Results of an acute toxicity study in algae.
8EHQ-0905-16212A (PDF)
(2 pp, 206K)
gamma-Butyrolactone 96-48-0 Y BASF Corporation Results of an acute eye irritation test in rabbits.
8EHQ-0905-16213A (PDF)
(2 pp, 148K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16214A (PDF)
(2 pp, 153K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16215A (PDF)
(2 pp, 155K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16216A (PDF)
(2 pp, 158K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16217A (PDF)
(2 pp, 146K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16218A (PDF)
(2 pp, 149K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16219A (PDF)
(2 pp, 150K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16220A (PDF)
(2 pp, 152K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16221A (PDF)
(2 pp, 149K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16222A (PDF)
(2 pp, 154K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16223A (PDF)
(92 pp, 6.22MB)
Petroleum industry chemicals Unknown   Metzger Law Group Final report of a case-control epidemiological study in workers.
8EHQ-0905-16224A (PDF)
(137 pp, 8.45MB)
Alkoxysilane Confidential   Center for Regulatory Services, Inc. Final reports of an in vitro chromosome aberration test in human lymphocytes; an in vitro bacterial reverse mutation test; an in vivo micronucleus test in mice; an acute oral toxicity study in rats; and an assessment of ready biodegradability.
8EHQ-0905-16225A (PDF)
(16 pp, 1.42MB)
Toluene diisocyanate 26471-62-5 Y American Chemistry Council Final report on human fatalities linked to diisocyanates.
8EHQ-0905-16226A (PDF)
(1 pg, 136K)
Mullite** 1302-93-8 N The Dow Chemical Company Results of 4-week and 13-week repeated dose inhalation toxicity studies in rats.
8EHQ-0905-16227A (PDF)
(1 pg, 123K)
Chemical*** Confidential N Syngenta Crop protection, Inc Results of a 1-year dietary toxicity study in dogs.
8EHQ-0905-16228A (PDF)
(2 pp, 206K)
Alkyl ammonium modified phenol salt Confidential   Confidential Results of a 31-day repeated dose toxicity study in rats by oral gavage.
8EHQ-0905-16229A (PDF)
(21 pp, 1.43MB)
Polysulfide polymer with thiol end groups 68611-50-7 N PPG Industries, Inc. Report of a case of work-related dermatitis associated with products containing the chemical and MSDSs.
Mercaptan terminated polysulfide 109159-22-0 N
8EHQ-0905-16230A (PDF)
(2 pp, 125K)
Substituted alkene Confidential   Confidential Results of an acute oral approximate lethal dose study in mice.
8EHQ-0905-16231A (PDF)
(2 pp, 157K)
Isotretinoin 4759-48-2 N BASF Corporation Results of an acute toxicity study in daphnia.
8EHQ-0905-16232A (PDF)
(2 pp, 162K)
Tetrabutylurea 4559-86-8 N BASF Corporation Results of an acute toxicity study in zebra fish.
8EHQ-0905-16233A (PDF)
(2 pp, 161K)
4-Methoxycinnamate** 5466-77-3 Y BASF Corporation Results of an acute toxicity study in daphnia.
8EHQ-0905-16234A (PDF)
(2 pp, 142K)
Dimethylsulfide borate 13292-87-0 N BASF Corporation Results of an acute toxicity study in rats.
8EHQ-0905-16235A (PDF)
(2 pp, 191K)
2-Ethylhexanal 123-05-7 Y BASF Corporation Results of a prenatal developmental toxicity study in rats by oral gavage.
8EHQ-0905-16236A (PDF)
(2 pp, 142K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16237A (PDF)
(2 pp, 196K)
Substituted amine* Confidential N BASF Corporation Results of a bioconcentration screening study in fathead minnows.
8EHQ-0905-16238A (PDF)
(2 pp, 141K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16239A (PDF)
(2 pp, 140K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16240A (PDF)
(2 pp, 148K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16241A (PDF)
(2 pp, 142K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16242A (PDF)
(2 pp, 140K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16243A (PDF)
(2 pp, 140K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16244A (PDF)
(2 pp, 143K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16246A (PDF)
(2 pp, 140K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16247A (PDF)
(2 pp, 143K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16248A (PDF)
(2 pp, 145K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16249A (PDF)
(2 pp, 144K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16250A (PDF)
(2 pp, 145K)
Substituted nitrogen-containing heterocycle* Confidential N BASF Corporation Results of an in vivo micronucleus screening test in mice.
8EHQ-0905-16251A (PDF)
(2 pp, 200K)
Mercaptoethyl tallate 68440-24-4 Y Thioesters Association Results of a combined repeated dose toxicity study with a reproductive and developmental toxicity screening test in rats by oral gavage (OECD TG 422).
8EHQ-0905-16252A (PDF)
(1 pg, 91K)
Halogenated oxygenated alcohol Confidential N The Dow Chemical Company Results of acute inhalation and oral toxicity studies in rats.
8EHQ-0905-16253A (PDF)
(122 pp, 15.33MB)
Tetrahydrofuran** 109-99-9 Y Lyondell Chemical Company Draft report of an in vitro percutaneous absorption study using human cadaver skin.
8EHQ-0905-00373BN (PDF)
(20 pp, 1.90MB)
Perfluorooctane-sulfonic acid, potassium salt 2795-39-3 N 3M Company Report of analytic results from human blood serum samples.
8EHQ-0905-00374C (PDF)
(20 pp, 2.46MB)
Perfluorooctanesul-fonic acid, potassium salt 2795-39-3 N 3M Company Report of analytic results from human blood serum samples.
8EHQ-0905-00394G (PDF)
(20 pp, 2.04MB)
Perfluorooctanoic acid 335-67-1 N 3M Company Report of analytic results from human blood serum samples.
8EHQ-0905-15572C Vinyl-tris(2-methoxyethoxy)silane 1067-53-4 Y Silicones Environmental Health and Safety Council Final report of a combined repeated-dose toxicity study with a reproductive and developmental toxicity screening test in rats by oral gavage (OECD TG 422).
8EHQ-0905-15856 (PDF)
(1 pg, 96K)
Perfluorooctanoic acid 335-67-1 N E.I. du Pont de Nemours Company Results of human blood monitoring.
8EHQ-0905-15991B (PDF)
(1 pg, 69K)
Substituted alkene Confidential N Confidential Results of an acute oral approximate lethal dose toxicity study in mice.
8EHQ-0905-16006B (PDF)
(1 pg, 69K)
Substituted alkene Confidential N Confidential Results of an acute oral approximate lethal dose study in mice.
8EHQ-0905-16007B (PDF)
(1 pg, 72K)
Substituted alkene Confidential N Confidential Results of an acute oral approximate lethal dose study in mice.
8EHQ-0905-16010B (PDF)
(179 pp, 22.37MB)
Benzenamine, N-phenyl-, reaction products with isobutylene and 2,4,4-trimethylpentene 184378-08-3 Y American Chemistry Council Final report of a combined repeated dose toxicity study and reproductive & developmental toxicity screening test in rats by oral gavage (OECD TG 422).
8EHQ-0905-16012C (PDF)
(4 pp, 350K)
Atplus7 UCL 1007 Confidential N Uniqema Response to request for chemical identity information.
8EHQ-0905-16104B (PDF)
(1 pg, 85K)
Lumiere Pink SM 0245N*** None N Cappelle Incorporated Commercial status of product in response to EPA inquiry.
8EHQ-0905-16105B (PDF)
(1 pg, 117K)
Substituted thiophene derivative**** Confidential N Confidential Results of a 104-week dietary carcinogenicity study in rats.
8EHQ-0905-16132B (PDF)
(2 pp, 101K)
Alkylborane complex Confidential   The Dow Chemical Company Response to EPA request for use, exposure and risk management information.
FYI-0905-01500A (PDF)
(548 pp, 47.11MB)
Dibromoacetic acid 631-64-1 N National Institute of Environmental Health Sciences Pathology Working Group report and Summary Pathology Tables of a dosed water carcinogenicity and chronic toxicity study in rats and mice.
Diisopropylcarbo-diimide 693-13-0 N Pathology Working Group report and Summary Pathology Tables of a dermal carcinogenicity and chronic toxicity study in rats and mice.
Divinylbenzene 1321-74-0 Y Pathology Working Group report and Summary Pathology Tables of an inhalation carcinogenicity and chronic toxicity study in rats and mice.
4-Methylimidazole 822-36-6 N Pathology Working Group report and Summary Pathology Tables of an oral feeding carcinogenicity and chronic toxicity study in rats and mice.
Methyl isobutyl ketone 108-10-1 Y Pathology Working Group report and Summary Pathology Tables of an inhalation carcinogenicity and chronic toxicity study in rats and mice.
FYI-0905-01501A (PDF)
(76 pp, 7.04MB)
Perfluorooctanoic acid 335-67-1 N 3M Company Pathology Working Group report examining mammary findings from a 1983 carcinogenicity and chronic toxicity feeding study in rats.

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A). Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.

FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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